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Official Full Name polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Background This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
Synonyms POLR2A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; RNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HeLa
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human POLR2A-1148H Human POLR2A HeLa N/A
    Human POLR2A-1149H Recombinant Human POLR2A, CT Domain E.coli N/A
    Human POLR2A-2513H Recombinant Human POLR2A, CT Domain, His-tagged E.coli His
    Human POLR2A-29986TH Recombinant Human POLR2A, His-tagged E.coli His
    Human POLR2A-3037HCL Recombinant Human POLR2A 293 Cell Lysate HEK293 N/A
    Human POLR2A-30767TH Recombinant Human POLR2A E.coli N/A
    Human POLR2A-8461H Recombinant Human POLR2A, His-tagged E.coli His
    Mouse POLR2A-13091M Recombinant Mouse POLR2A Protein Mammalian Cell His

    polr2a involved in several pathways and played different roles in them. We selected most pathways polr2a participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with polr2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism AK9; PRPS1B; PRIM1; AMPD3B; POLR3C; POLE; POLE3; ZNRD1; POLR1D; NT5C1A
    Pyrimidine metabolism POLR2E; DPYD; DCK; ENTPD5; POLR1B; AK9; CMPK; ITPA; NT5C1B; NME3
    Metabolic pathways CHKA; PPT1; PIGW; ATP6V1D; HIBADHB; HSD3B7; BCMO1; POLR1B; PRPS1A; ACADSB
    Huntingtons disease TFAM; UQCRQ; POLR2B; CREB3L2; NDUFC1; NDUFA12; SOD1; POLR2I; UQCR10; ATP5J
    Herpes simplex infection IFNA5; SRPK1A; HNRPKL; CUL1A; CASP3A; TAF10; TAF13; UBE2R2; STAT1B; BF1
    Epstein-Barr virus infection PSMD8; MAPK13; IKBKG; SND1; TRAF1; ICAM1; HSPA6; PRKACG; YWHAB; PSMC2

    polr2a has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by polr2a itself. We selected most functions polr2a had, and list some proteins which have the same functions with polr2a. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SUPT3H; THAP6; RHOXF1; ZNF689; LIG1; CDK5R2; TDP2B; PHTF2; ZNF554; NUSAP1
    DNA-directed RNA polymerase activity POLR3F; POLR2E; POLR3B; POLR2B; POLRMT; POLR2J; POLR2I; MED21; PRIM2; POLR3G
    contributes_to RNA polymerase II activity POLR2A; POLR2L; POLR2J; POLR2C; POLR2E; POLR2K; POLR2J2; POLR2H; POLR2B; POLR2EB
    RNA-directed RNA polymerase activity POLR2A
    metal ion binding ZNF582; TNNI3K; MAP2K2; ZFP704; ZNF354A; ZNF705B; NINL; ARSG; MBNL1; DYTN
    poly(A) RNA binding KIAA1324; SNRPN; DROSHA; TMEM38A; PARN; FSCN1; MAPRE1; EWSR1; S100A4; HIST1H4F
    protein binding IL32; PARVG; THOC1; EYA4; CD160; VPS11; PHB2; CENPK; MED12; BRAF
    contributes_to protein binding POLR2A; MSH6; INTS10; TAF10; TGFBR3; MLH1; MEF2A; MSH2; CPSF3L; PAK1
    ubiquitin protein ligase binding MOAP1; UBOX5; UBE2C; SLC22A18; MDM2; UBXN6; TRAF4; CDC34; LTBR; CKB

    polr2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with polr2a here. Most of them are supplied by our site. Hope this information will be useful for your research of polr2a.


    Yamada, K; Hayashi, M; et al. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription. PLOS ONE 8:-(2013).
    Komashko, VM; Acevedo, LG; et al. Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells. GENOME RESEARCH 18:521-532(2008).

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