PPM1D

Official Full Name

protein phosphatase, Mg2+/Mn2+ dependent, 1D
Overview

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Synonyms

PPM1D; protein phosphatase, Mg2+/Mn2+ dependent, 1D; WIP1; PP2C-DELTA; protein phosphatase 1D; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; protein phosphatase 2C delta isoform; protein phosphatase 1D magnesium-dependent, delta isoform;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
Fc
Avi
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPM1D-1744H	Recombinant Human PPM1D Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	PPM1D-2668H	Recombinant Human PPM1D Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	PPM1D-2917H	Recombinant Human PPM1D protein, His-tagged	E.coli	His	254-423 aa	$319 / 25μg
Human	PPM1D-1744H-B	Recombinant Human PPM1D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	PPM1D-324HFL	Recombinant Full Length Human PPM1D Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Mouse	Ppm1d-5046M	Recombinant Mouse Ppm1d Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Rhesus Macaque	PPM1D-3553R	Recombinant Rhesus monkey PPM1D Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PPM1D-3371R	Recombinant Rhesus Macaque PPM1D Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	PPM1D-3371R-B	Recombinant Rhesus Macaque PPM1D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

PPM1D involved in several pathways and played different roles in them. We selected most pathways PPM1D participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PPM1D has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1D itself. We selected most functions PPM1D had, and list some proteins which have the same functions with PPM1D. You can find most of the proteins on our site.

Function	Related Protein

PPM1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1D here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1D.