pqbp1 Protein, polyglutamine binding protein 1


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Official Full Name polyglutamine binding protein 1
Background This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Synonyms PQBP1; polyglutamine binding protein 1; mental retardation, X linked 55 , MRX55, MRXS8, RENS1, SHS, Sutherland Haan X linked mental retardation syndrome; polyglutamine-binding protein 1; 38 kDa nuclear protein containing a WW domain; Mental retardation, X linked 55; MRX55; MRXS3; MRXS8; Npw38; Nuclear protein containing WW domain 38 kD; OTTHUMP00000025808; Polyglutamine tract binding protein 1; PQBP 1; RENS1; SHS; Sutherland Haan X linked mental retardation syndrome; PQBP-1; OTTHUMP00000025809; OTTHUMP00000025812; polyglutamine tract-binding protein 1
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PQBP1-1933H Recombinant Human PQBP1, His-tagged E.coli His
    Human PQBP1-2903HCL Recombinant Human PQBP1 293 Cell Lysate HEK293 N/A
    Human PQBP1-6773H Recombinant Human Polyglutamine Binding Protein 1, His-tagged E.coli His
    Rat PQBP1-4651R Recombinant Rat PQBP1 Protein Mammalian Cell His
    Rhesus Macaque PQBP1-3584R Recombinant Rhesus monkey PQBP1 Protein, His-tagged Mammalian Cell His
    Zebrafish PQBP1-568Z Recombinant Zebrafish PQBP1 Mammalian Cell His

    pqbp1 involved in several pathways and played different roles in them. We selected most pathways pqbp1 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with pqbp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome HNRNPA3; RBM25; SF3B14; HNRNPA1L2; SART1; SF3B6; NCBP2; NHP2L1; SF3B3; SRSF9

    pqbp1 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pqbp1 itself. We selected most functions pqbp1 had, and list some proteins which have the same functions with pqbp1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding RPL6; SSH2B; NUPR1; IER2; CDX1A; THAP11; KLF5; ZNF785; ZNF398; ZBTB48
    protein C-terminus binding ERCC1; PPP2CB; PPP1R9B; CDC20; DYNLL1; DDX1; PHB2; PFKM; CALCOCO1; SDCBP2
    protein binding INSIG2; PUF60; CA1; CCDC6; EIF3M; NPY2R; CBFB; ZFP64; TTN; B4GALT7
    ribonucleoprotein complex binding YBX2; BOP1; RNF135; ITCH; UHMK1; SRP54; PES; CKAP5; PPIH; PRMT7
    transcription coactivator activity ABT1; NCOA3; JMY; RNF14; CARM1; TUBB3; SP100; SMARCB1; MED7; LPIN3

    pqbp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pqbp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of pqbp1.


    Hoop, CL; Lin, HK; et al. Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance. BIOCHEMISTRY 53:6653-6666(2014).
    Cui, XT; Liang, QN; et al. TR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes. SCIENTIFIC REPORTS 4:-(2014).

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