PRDM1

  • Official Full Name

    PR domain containing 1, with ZNF domain

  • Overview

    This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically;to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases;upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

  • Synonyms

    PRDM1;PR domain containing 1, with ZNF domain;PR domain zinc finger protein 1;PR domain-containing protein 1;B lymphocyte induced maturation protein;B lymphocyte-induced maturation protein 1;beta-interferon gene positive regulatory domain I-binding factor;Blimp1;Blimp-1;PRDI-BF1;ZNFPR1A1

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Flag
  • T7
  • Avi
  • Fc

    Involved Pathway

    PRDM1 involved in several pathways and played different roles in them. We selected most pathways PRDM1 participated on our site, such as Direct p53 effectors,NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NOD pathway NLRP12,COPS6,NLRP4,NLRP2,NLRP3,NLRP10,NLRP7,SUGT1,AAMP
    Direct p53 effectors AIFM2,ZNF385A,PPM1J,S100A2,CD82,GADD45A,CTSD,DUSP1,PLK3,PCBP4

    Protein Function

    PRDM1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,histone deacetylase binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM1 itself. We selected most functions PRDM1 had, and list some proteins which have the same functions with PRDM1. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase binding SKOR2,BRMS1LA,WDTC1,NR2C1,YWHAB,ZFP932,ZMYND15,RBBP4,TOP2B,HEY2
    protein binding HTR3C,CCBE1,NRG4,LILRB4,SIRT3,DLL4,SYN1,ISY1,TBC1D9B,USP54
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding BCL11AB,HSF1,NEUROG3,NFATC2,PITX2,CC2D1B,NACC2,SKIL,ASCL1,BATF3
    transcription factor activity, sequence-specific DNA binding RHOXF1,HOXA3,ZNF12,PHF1,TEAD3B,MYCL1,IKZF5,SREBF1,NR1D4A,HOMEZA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOXI1,KCNIP3,ELF3,TBP,FOXK2,ZNF257,MEOX2,RFX4,ZIC1,SKIL
    metal ion binding ING5B,PITPNM1,SDF4,PVALB3,TESK1,TNFRSF11A,ZFP551,ZNF649,ZNF598,PDLIM3A
    methyltransferase activity TYW3,METTL23,NDUFAF5,NSUN3,TOMT,WBP7,COMTB,PRMT1,N6AMT2,PCMTL

    Interacting Protein

    PRDM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM1.

    PIAS1;HSP90AB1;SUMO1;CDC37;ATXN1;clpB;ifnl1_human_gene

    Resources

    Gene Families

    Cytokines

    Research Area

    Germ Cell Markers
    Cancer Stem Cell Transcription Factors
    B Cell Transcription Factors
    T Follicular Helper (Tfh) Cells

    References

    • Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    • White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All PRDM1 Products

    Required fields are marked with *

    My Review for All PRDM1 Products

    Required fields are marked with *