PRDM1 Protein

September 27-30, 2022

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Home / Products / PRDM1


Official Full Name PR domain containing 1, with ZNF domain
Background This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically;to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases;upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
Synonyms PRDM1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; B lymphocyte induced maturation protein; B lymphocyte-induced maturation protein 1; beta-interferon gene positive regulatory domain I-binding factor; Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • Flag
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse PRDM1-13309M Recombinant Mouse PRDM1 Protein Mammalian Cell His
    Human PRDM1-2887HCL Recombinant Human PRDM1 293 Cell Lysate HEK293 N/A
    Human PRDM1-2890HCL Recombinant Human PR domain containing 1 cell lysate, transcript variant 2 HEK293T Flag
    Human PRDM1-2891HCL Recombinant Human PR domain containing 1 cell lysate, transcript variant 1 HEK293T Flag
    Human PRDM1-1758H Recombinant Human PRDM1 protein, His-tagged E.coli His
    Mouse Prdm1-1928M Recombinant Mouse Prdm1 protein, His & T7-tagged E.coli His/T7
    Rat Prdm1-1929R Recombinant Rat Prdm1 protein, His & T7-tagged E.coli His/T7

    PRDM1 involved in several pathways and played different roles in them. We selected most pathways PRDM1 participated on our site, such as Direct p53 effectors, NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Direct p53 effectors DUSP5; EPHA2; FDXR; SMARCA4; DUSP1; BCL2L14; CSE1L; DDB2; BNIP3L; CTSD

    PRDM1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, histone deacetylase binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM1 itself. We selected most functions PRDM1 had, and list some proteins which have the same functions with PRDM1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding BATF; GMEB1; RFX8; ZNF217; MEOX1; KDM6A; ZNF148; NFIC; TP73; PATZ1
    histone deacetylase binding TOP2B; SUDS3; HDAC9; RAD9; MAGEA2; FOXP3; CRY1; MYOCD; PKN2; KLF4
    metal ion binding GLIS2B; ZNF165; NCALDB; ATX1; ZBTB10; CHORDC1; PPM1G; ZFP326; ZNF222; CD209C
    methyltransferase activity PRDM14; CIAPIN1; RG9MTD1; PRDM5; PRMT1; PRMT3; TPMT.1; SKINT8; RNMTL1A; FTSJD1
    protein binding ATP5G1; SGCA; GLRB; MPZL2B; SCYL1; ZNF286A; PGRMC1; LRRC4C; OS9; KEL
    transcription factor activity, sequence-specific DNA binding TAF1B; ZNF383; NKX3; SNAPC4; FOXD3; HEY2; TCF19; CITED2; CARF; ZFP146
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NKX3-2; RCOR1; ZBTB20; TCF21; PYDC3; NKX6; NFIL3-6; SFPI1; MLXIPL; SNAI1

    PRDM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM1.

    PIAS1; HSP90AB1; SUMO1; CDC37; ATXN1; clpB; ifnl1_human_gene

    Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

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