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PRDM16

Official Full Name

PR domain containing 16
Overview

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms

PRDM16; PR domain containing 16; MEL1; LVNC8; PFM13; CMD1LL; PR domain zinc finger protein 16; MDS1/EVI1-like gene 1; transcription factor MEL1;

Type

Recombinant Proteins

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mamanlian cells

Tag

Flag
GST
His
SUMO
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PRDM16-31106TH	Recombinant Human PRDM16, His-tagged	E.coli	His	984-1275	Inquiry
Human	PRDM16-8327H	Recombinant Human PRDM16 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	PRDM16-301430H	Recombinant Human PRDM16 protein, GST-tagged	E.coli	GST	Ile1080-Lys1230	Inquiry
Human	PRDM16-3097HFL	Recombinant Full Length Human PRDM16 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	PRDM16-3333H	Recombinant Human PRDM16 protein, His-tagged	E.coli	His	Ala82~Lys211	Inquiry
Human	PRDM16-3247H	Recombinant Human PRDM16 protein, His-tagged	E.coli	His	Ala82~Lys211	Inquiry
Human	PRDM16-3254H	Recombinant Human PRDM16 protein, His-SUMO-tagged	E.coli	His&SUMO	Ala82~Lys211	Inquiry
Mouse	Prdm16-5100M	Recombinant Mouse Prdm16 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PRDM16 involved in several pathways and played different roles in them. We selected most pathways PRDM16 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PRMT5;SAP30;KDM5BB;KDM6B;KDM4C;CAPNS2;KANSL2;SMARCE1;SMARCC1
Chromatin organization	KANSL2;KDM7AB;SUDS3;SUZ12;PAX3A;KDM2B;KDM1A;PHF21A;SMARCE1
PKMTs methylate histone lysines	SMYD2;EED;AEBP2;ASH2L;SMYD3;PRDM16;DPY30;EHMT2;ATF7IP

PRDM16 has several biochemical functions, for example, SMAD binding, activating transcription factor binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM16 itself. We selected most functions PRDM16 had, and list some proteins which have the same functions with PRDM16. You can find most of the proteins on our site.

Function	Related Protein
SMAD binding	SKIB;SKOR1A;SKIL;PML;ACVRL1;PRDM16;COL1A2;CTNNB1;TGFBR2
activating transcription factor binding	HDAC7;EP300;MEF2D;ATOH8;PRDM16;GATA4;PSIP1;MEF2C;SMAD2
metal ion binding	GPHN;ZNF143;ZC3H3;GGPS1;ZNF230;TRAF4B;KSR2;MGAT4A;JAZF1B
protein binding	CENPP;GNAT1;CXorf41;MYEF2;COL6A5;PIM1;ITGA2;NCBP2;BCKDHA
sequence-specific DNA binding	MKX;SPIB;POU3F2B;BPTF;RREB1;DLX4A;CAMTA1;EGR1;RHOXF2
transcription coactivator activity	FHL5;SUPT7L;PRDM16;SMARCA2;SUB1B;MED12;NR1H4;TAF11;MED17

PRDM16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM16 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM16.

mdm2_human_probe