PRDM16 Protein

September 27-30, 2022

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PRDM16

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PRDM16

Official Full Name PR domain containing 16
Background The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms PRDM16; PR domain containing 16; MEL1; LVNC8; PFM13; CMD1LL; PR domain zinc finger protein 16; MDS1/EVI1-like gene 1; transcription factor MEL1;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mamanlian cells
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRDM16-31106TH Recombinant Human PRDM16, His-tagged E.coli His
    Human PRDM16-8327H Recombinant Human PRDM16 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRDM16-301430H Recombinant Human PRDM16 protein, GST-tagged E.coli GST
    Human PRDM16-3097HFL Recombinant Full Length Human PRDM16 protein, Flag-tagged Mamanlian cells Flag
    Mouse Prdm16-5100M Recombinant Mouse Prdm16 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    PRDM16 involved in several pathways and played different roles in them. We selected most pathways PRDM16 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes KDM5BA; PADI2; SUZ12A; MEAF6; KDM4A; KANSL2; KDM5C; KDM4D; TADA1; SAP30L
    Chromatin organization PRMT5; RBBP5; YEATS4; SUDS3; MSL2; BRMS1; MSL2B; BRD8; COPRS; PHF20B
    PKMTs methylate histone lysines SUZ12A; EED; DPY30; ATF7IP; EHMT2; SUZ12B; RBBP5; SMYD3; SUZ12; PRDM16

    PRDM16 has several biochemical functions, for example, SMAD binding, activating transcription factor binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM16 itself. We selected most functions PRDM16 had, and list some proteins which have the same functions with PRDM16. You can find most of the proteins on our site.

    Function Related Protein
    SMAD binding FOXH1; ACVR1; SKILB; USP15; BMPR1B; SKIL; CREBBP; MAGI2; RNF111; COL1A2
    activating transcription factor binding MEF2D; MEF2A; PPARG; RELA; ZFP516; HDAC4; MEF2C; PSIP1; TAF9; GATA4
    metal ion binding PLEKHM1P; MYOC; ACAT1; NMRK1; ANKIB1; JMJD1C; EYA1; SHRPRBCK1R; LIMS2; ZC3H13
    protein binding PRMT3; IRX1; NRADD; MTPAP; IRF4; LMNA; TBC1D16; SOST; SCO2; RBM42
    sequence-specific DNA binding CEBPD; HOXC8; ZFP42; MAEL; NR2F6A; TCF7L1A; SOX17; SALL4; DLX5A; HOXB1
    transcription coactivator activity Ankar; HCFC2; PCBD1; CITED4; TCERG1; JUND; FHL2; MKL1; TGFB1I1; NR2C2

    PRDM16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM16 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM16.

    mdm2_human_probe

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