PRELP

  • Official Full Name

    proline/arginine-rich end leucine-rich repeat protein

  • Overview

    The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.
  • Synonyms

    PRELP; proline/arginine-rich end leucine-rich repeat protein; proline arginine rich end leucine rich repeat protein; prolargin; prolargin proteoglycan; SLRR2A; 55 kDa leucine rich repeat protein of articular cartilage; MST161; MSTP161; PRELP_HUMAN; Proline-arginine-rich end leucine-rich repeat protein; Proline/arginine rich end leucine rich repeat protein; OTTHUMP00000034099; 55 kDa leucine-rich repeat protein of articular cartilage;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRELP-30073TH Recombinant Human PRELP Wheat Germ N/A 85 amino acids
Human PRELP-372H Recombinant Human PRELP, Fc-tagged Human Cell Fc Gln21-Ile382
Human PRELP-371H Recombinant Human PRELP Human Cell N/A Gln21-Ile382
Human PRELP-002HCL Recombinant Human PRELP cell lysate Human Cell N/A
Human PRELP-001HCL Recombinant Human PRELP cell lysate Human Cell N/A
Human PRELP-6145H Recombinant Human PRELP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRELP-2906H Recombinant Human PRELP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Prelp-579M Recombinant Mouse Prelp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PRELP-4664R Recombinant Rat PRELP Protein Mammalian Cell His
Rat PRELP-4323R-B Recombinant Rat PRELP Protein Pre-coupled Magnetic Beads HEK293
Rat PRELP-4323R Recombinant Rat PRELP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRELP-3596R Recombinant Rhesus monkey PRELP Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRELP-3414R-B Recombinant Rhesus Macaque PRELP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PRELP-3414R Recombinant Rhesus Macaque PRELP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PRELP involved in several pathways and played different roles in them. We selected most pathways PRELP participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRELP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)ACAN;FMOD;OGN;KERA;PRELP
Defective CHST6 causes MCDC1OGN;KERA;PRELP;ACAN;FMOD
Defective ST3GAL3 causes MCT12 and EIEE15KERA;PRELP;ACAN;FMOD;OGN
DiseaseCOBRA1;TNKS2;FDX1L;CTDP1;HEY1;CYP11A1;CHMP4C;OPN1LW;AP2B1
Diseases associated with glycosaminoglycan metabolismPRELP;ACAN;FMOD;KERA;OGN
Diseases of glycosylationOGN;ACAN;FMOD;KERA;PRELP
Glycosaminoglycan metabolismCHST14;UST;KERA;B3GAT2;GPC1B;HPSE;VCANB;PRELP;B3GNT3
Keratan sulfate biosynthesisOGN;PRELP;KERA;B3GNT3;OMD;B3GNT1;B3GNT2A;ST3GAL3A;FMODA

PRELP has several biochemical functions, for example, extracellular matrix structural constituent, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRELP itself. We selected most functions PRELP had, and list some proteins which have the same functions with PRELP. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituentKAL1;COL5A2;CHI3L1;FBLN2;COL5A3B;MEPE;COL1A1;FBLN1;TINAGL1
heparin bindingAAMP;SLIT1;COL25A1;COL5A1;WISP3;APPB;CHRD;RSPO2;PRG2

PRELP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRELP here. Most of them are supplied by our site. Hope this information will be useful for your research of PRELP.

Dlg4; yjdI

Research Area

Related articles

Birke, MT; Lipo, E; et al. AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. GENE THERAPY 21:507-513(2014).
Rucci, N; Capulli, M; et al. Proline/arginine-rich end leucine-rich repeat protein N-terminus is a novel osteoclast antagonist that counteracts bone loss. JOURNAL OF BONE AND MINERAL RESEARCH 28:1912-1924(2013).
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