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Official Full Name protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms PRKAG1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; 5-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK gamma-1 chain; 5-AMP-activated protein kinase, gamma-1 subunit; AMPKG; MGC8666
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRKAG1-2334H Recombinant Human PRKAG1, His-tagged E.coli His
    Human PRKAG1-2865HCL Recombinant Human PRKAG1 293 Cell Lysate HEK293 N/A
    Human PRKAG1-2866HCL Recombinant Human PRKAG1 293 Cell Lysate HEK293 N/A
    Human PRKAG1-31763TH Recombinant Human Human Human PRKAA1, His-tagged His
    Human PRKAG1-365H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP
    Human PRKAG1-366H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP
    Human PRKAG1-367H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP
    Mouse PRKAG1-13354M Recombinant Mouse PRKAG1 Protein Mammalian Cell His
    Mouse Prkag1-5113M Recombinant Mouse Prkag1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PRKAG1-4673R Recombinant Rat PRKAG1 Protein Mammalian Cell His
    Rhesus Macaque PRKAG1-3603R Recombinant Rhesus monkey PRKAG1 Protein, His-tagged Mammalian Cell His
    Chicken PRKAG1-3285C Recombinant Chicken PRKAG1 Mammalian Cell His
    Zebrafish PRKAG1-12377Z Recombinant Zebrafish PRKAG1 Mammalian Cell His

    prkag1 involved in several pathways and played different roles in them. We selected most pathways prkag1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with prkag1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PRKAG1; MAP2K2B; MDM2; FOXG1A; AKT2L; IGF1RB; TGFBR1; PIK3R3B; PIK3R2; PIK3R3
    AMPK signaling pathway AKT2; PIK3R5; SIRT1; EEF2; CREB3; G6PC3; LEP; SLC2A4; CPT1C; RPTOR
    Circadian rhythm RORA; PER3; PRKAA2; CLOCK; SKP1; CSNK1E; PRKAG1; RBX1; PRKAA1; BHLHE40
    Insulin signaling pathway PHKG1A; ARAF; PRKACB; CALM1; EXOC7; FOXO1; MKNK2B; FASN; MAPK3; RAF1A
    Adipocytokine signaling pathway NFKBIB; G6PC; PTPN11A; ACSL1; NFKBIAB; STK11; CD36; NPY; ADIPOR2; CPT1C
    Oxytocin signaling pathway CACNA2D4; PLA2G4D; NFATC1; CACNG4; CACNA2D2; PIK3CB; HRAS; GNAQ; KRAS; PPP3R1
    Glucagon signaling pathway PPP3CA; CALM1; PPP3CB; PPP3R1; PCK2; PPP4C; ITPR1; PYGL; PDHB; PRKACG
    Insulin resistance INSR; PYGM; PTENB; FOXO1A; INS1; PPP1CAA; GSK3AA; PIK3CA; G6PCA.2; PRKAG2
    Non-alcoholic fatty liver disease (NAFLD) NDUFA6; UQCRB; NR1H3; IRS1; IL1B; KCNA3; NDUFC2; RAC1; IKBKB; NFKB1
    Hypertrophic cardiomyopathy (HCM) ACTC1; ITGA3; MYH7; LAMA2; PRKAB2; CACNA2D3; ITGA2B; ITGB7; CACNG6; TGFB1

    prkag1 has several biochemical functions, for example, ADP binding, AMP binding, contributes_to AMP-activated protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by prkag1 itself. We selected most functions prkag1 had, and list some proteins which have the same functions with prkag1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to AMP-activated protein kinase activity PRKAG1; PRKAB2
    cAMP-dependent protein kinase activity PRKACG; PRKACB; PRKAA1; AKAP13; PRKACA; PRKX; PRKAG1
    cAMP-dependent protein kinase regulator activity PRKAR2B; PRKAR2A; CXCL10; PRKAR1AB; PRKAR1AA; PRKAR1A; PRKAR2AA; PRKAG2; PRKAR1B; PRKAR2AB
    protein binding GRIN2B; FGF1; PRMT3; TTN; YWHAG; ASCL3; IFT122; TWF2; ANKZF1; C1orf65
    protein kinase activity OXSR1B; DAPK1; EGFRA; RPS6KA3B; CAMK1GA; MMD2; PLK2B; VSIG8B; HIPK2; MAP3K10
    protein kinase binding RICTOR; MAP3K2; ZFP36; MAP3K12; CDC25B; PAX6; FAM83A; XBP1; TPRKB; NME2

    prkag1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with prkag1 here. Most of them are supplied by our site. Hope this information will be useful for your research of prkag1.


    Lindholm-Perry, AK; Kuehn, LA; et al. DNA polymorphisms and transcript abundance of PRKAG2 and phosphorylated AMP-activated protein kinase in the rumen are associated with gain and feed intake in beef steers. ANIMAL GENETICS 45:461-472(2014).
    Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).

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