PRKAR1B Protein


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Official Full Name protein kinase, cAMP-dependent, regulatory, type I, beta
Background Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.[supplied by OMIM, Jun 2009]
Synonyms PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta; PRKAR1; cAMP-dependent protein kinase type I-beta regulatory subunit;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRKAR1B-1951H Recombinant Human PRKAR1B, GST-tagged E.coli GST
    Human PRKAR1B-28125TH Recombinant Human PRKAR1B, His-tagged E.coli His
    Human PRKAR1B-2862HCL Recombinant Human PRKAR1B 293 Cell Lysate HEK293 N/A
    Human PRKAR1B-29537TH Recombinant Human PRKAR1B, His-tagged His
    Human PRKAR1B-4392H Recombinant Human PRKAR1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PRKAR1B-4872H Recombinant Human Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta, His-tagged Sf9 Insect Cell His
    Human PRKAR1B-7015H Recombinant Human PRKAR1B, His-tagged Sf9 Insect Cell His
    Mouse PRKAR1B-13358M Recombinant Mouse PRKAR1B Protein Mammalian Cell His
    Mouse Prkar1b-5115M Recombinant Mouse Prkar1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish PRKAR1B-4514Z Recombinant Zebrafish PRKAR1B Mammalian Cell His

    PRKAR1B involved in several pathways and played different roles in them. We selected most pathways PRKAR1B participated on our site, such as Apoptosis, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin signaling pathway PPP1R3B; PRKAR1AB; PCK2; RAF1A; INS2; PRKAR1A; RPS6KB1B; MAP2K1; PIK3R2; CALM2A

    PRKAR1B has several biochemical functions, for example, cAMP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAR1B itself. We selected most functions PRKAR1B had, and list some proteins which have the same functions with PRKAR1B. You can find most of the proteins on our site.

    Function Related Protein
    cAMP-dependent protein kinase inhibitor activity PKIG; PKIB; PRKAG2; PRKAR2A; PRKAR1A; PRKAR2B; PKIA; PRKAR1B
    cAMP-dependent protein kinase regulator activity PRKAR1AB; PRKAR1B; PRKAR2A; PRKAR2B; PRKAR1A; PRKAR2AA; PRKAG1; PRKAR1AA; PRKAG2; PRKAR2AB
    protein kinase A catalytic subunit binding GSK3B; PRKAR2A; RYR2; PRKAR1A; EZR; PRKAR2B; PRKAR1B; GSK3A; PKIA; SOX9

    PRKAR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAR1B.

    PRKACA; kemptide; Dlg4; EGFR; UBE2I; hmuV; manB

    Loza-Huerta, A; Vera-Estrella, R; et al. Certain Strongylocentrotus purpuratus sperm mitochondrial proteins co-purify with low density detergent-insoluble membranes and are PKA or PKC-substrates possibly involved in sperm motility regulation. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1830:5305-5315(2013).
    Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).

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