Prkar2b

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Prkar2b

Official Full Name protein kinase, cAMP-dependent, regulatory, type II, beta
Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Synonyms PRKAR2B; protein kinase, cAMP-dependent, regulatory, type II, beta; PRKAR2; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; WUGSC:H_RG363E19.2; cAMP-dependent protein kinase type II-beta regulatory chain; RII-BETA
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRKAR2B-301518H Recombinant Human PRKAR2B protein, GST-tagged E.coli GST
    Human PRKAR2B-1501H Recombinant Human PRKAR2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRKAR2B-1952H Recombinant Human PRKAR2B, His-tagged E.coli His
    Human PRKAR2B-2860HCL Recombinant Human PRKAR2B 293 Cell Lysate HEK293 N/A
    Human PRKAR2B-398H Recombinant Human PRKAR2B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse PRKAR2B-13360M Recombinant Mouse PRKAR2B Protein Mammalian Cell His
    Mouse Prkar2b-5117M Recombinant Mouse Prkar2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PRKAR2B-4676R Recombinant Rat PRKAR2B Protein Mammalian Cell His
    Rat Prkar2b-609R Recombinant Rat Prkar2b E.coli N/A

    Prkar2b involved in several pathways and played different roles in them. We selected most pathways Prkar2b participated on our site, such as Apoptosis, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkar2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis CAPN1A; NGF; BIRC8; TNFRSF10C; RIPK1L; GZMC; BID; PPP3CC; ADD1; BCAP31
    Insulin signaling pathway CALM3; RHOQ; HKDC1; PRKAG2; CALM; SREBF1; ACACA; PIK3R2; INSRB; G6PC3

    Prkar2b has several biochemical functions, for example, cAMP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkar2b itself. We selected most functions Prkar2b had, and list some proteins which have the same functions with Prkar2b. You can find most of the proteins on our site.

    Function Related Protein
    cAMP binding RAPGEF3; CNGA4; PDE4D; PDE4A; PDE4B; CNMPD1; PDE3A; PRKAR1B; PDE11A; PDE2A
    cAMP-dependent protein kinase inhibitor activity PRKAR1A; PKIB; PRKAR2A; PKIG; PRKAR2B; PRKAR1B; PKIA; PRKAG2
    cAMP-dependent protein kinase regulator activity PRKAR1AB; PRKAR1AA; CXCL10; PRKAR2AB; PRKAR2AA; PRKAR2B; PRKAR2A; PRKAG2; PRKAR1A; PRKAR1B
    protein domain specific binding HPCAL4; HIST1H4F; XPA; DBNL; ABCC2; IGBP1; WNT1; VCP; FOXA3; GUSB
    protein kinase A catalytic subunit binding KCNQ1; RYR2; PRKAR2A; PRKAR2B; PKIA; GSK3A; SOX9; PRKAR1A; PRKAR1B; PJA2
    ubiquitin protein ligase binding TRAF3; CASP10; SMAD7; PIAS2; TNFRSF1B; DIO2; LRPPRC; CUL2; BRCA1; MYOD1

    Prkar2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkar2b here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkar2b.

    PRKACA; 3',5'-cyclic amp; PRKACB; ARFGEF2; 7-ch-c_amp; sp-8-br-7-ch-camps; 7-ch-cgmp; kemptide; p03259-2; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; PCM1

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