Prkca
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Official Full Name
protein kinase C, alpha
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Overview
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008] -
Synonyms
PRKCA; protein kinase C, alpha; AAG6; PKCA; PRKACA; PKC-alpha; protein kinase C alpha type; PKC-A; aging-associated gene 6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
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- Insect cell
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- DDK
- GST
- His
- His (Fc)
- Avi
- His|S
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Prkca involved in several pathways and played different roles in them. We selected most pathways Prkca participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkca were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | ARRB1;RAP1AB;GNG12;FGF14;RELA;MAX;RAC3;AKT2;BDNF |
| ErbB signaling pathway | PIK3R3B;MYCB;CAMK2A;RAF1A;MTOR;NCK1;MAP2K2;SOS1;CDKN1BB |
| Ras signaling pathway | INS1;SHC4;REL;RASGRF2;PLCE1;PLA2G1B;RASA1;FGF20;RAB5B |
| Rap signaling pathway | Kitl;CALM3;NGF;INSR;THBS1;PIK3R3;FGFR2;RAP1A;RRAS |
| Calcium signaling pathway | SLC8A1A;RYR2;ATP2A1L;ADORA2A;P2RX7;ADRB2B;HTR2C;P2RX3;PRKCG |
| HIF- signaling pathway | HIF1A;MKNK2;EIF4E1B;PLCG1;EIF4E2;PFKFB3;NOX1;TIMP1;SERPINE1 |
| Phosphatidylinositol signaling system | PIP5K1AA;CALM1A;CDS1;INPP4AB;IMPA2;CALML3;PIP5K2;PIK3CD;PRKCB |
| Sphingolipid signaling pathway | S1PR2;PPP2R1B;PIK3R3;ROCK2;PRKCG;LASS1;PIK3R5;TNF;PPP2R5D |
| Phospholipase D signaling pathway | PIK3CB;PLD1;FCER1G;Pdgfa&Pdgfb;GRM7;GAB1;PLA2G4F;PIP5K1B;DNM3 |
| mTOR signaling pathway | TNF;PRKCA;PIK3R3B;PRKCB;RRAGD;AKT1S1;EIF4E2RS1;RRAGC;BRAF |
| PIK-Akt signaling pathway | IFNAR1;ITGA5;INSR;MTOR;PCK1;FGFR1;FGF22;LPAR4;COL6A6 |
| Adrenergic signaling in cardiomyocytes | ADRB2B;TPM4B;MAPK11;MAPK12B;PPP1CB;ATP2B4;BCL2;CALML5;GNAI1 |
| Vascular smooth muscle contraction | PRKCA;MYLK4;GNAQ;CALM;PRKCDA;Adcy4;NPR1A;PPP1R12A;MAPK1 |
| Wnt signaling pathway | FZD7;PRKCA;CER1;WNT5A;WNT2BA;WNT4;SFRP2;CAMK2B1;RAC2 |
| VEGF signaling pathway | PIK3CA;MAPK12B;MAPK11;SPHK2;PPP3R1B;SHC2;MAPK14A;PXN;PIK3R5 |
| Focal adhesion | PIP5K1C;TLN2A;BCL2;ACTN3;ITGB1;CHAD;CCND3;RAP1AB;MYL10 |
| Tight junction | RRAS;MYH1;CSNK2A2A;CLDN16;CLDN20;MPP5;AKT1;LLGL2;MYL7 |
| Gap junction | GNAI2B;GJD2;RAF1;TUBA8L2;MAPK1;TUBB2A;PDGFRB;ADCY1B;HRAS |
| Natural killer cell mediated cytotoxicity | PTPN11;KIR2DL3;TNFRSF10B;RAF1;MAP2K2;ZAP70;NFATC1;KLRA8;ULBP2 |
| Fc epsilon RI signaling pathway | MAP2K2;SOS1;MAP2K4;PDPK1;VAV1;PLA2G4B;MAP2K3;NRAS;MAP2K1 |
| Fc gamma R-mediated phagocytosis | PIK3CA;cgr2b;CFL2;WASF3;ARPC1A;RAF1;FCGR3A;ASAP1;PRKCA |
| Leukocyte transendothelial migration | CD99;ICAM1;CLDN3;CLDN4;CLDN9;MAPK11;PIK3R1;VAV3;PTK2 |
| Circadian entrainment | ITPR3;NOS1AP;GNB3;CAMK2D;Adcy4;MAPK3;MTNR1B;GNG3;GRIN1 |
| Long-term potentiation | PPP3CA;GRM5;MAP2K1;PPP3R1;GNAQ;EP300;CAMK4;MAPK3;ITPR3 |
| Retrograde endocannabinoid signaling | GABRA5;GABRA2;NAPEPLD;GNG12;GABRB3;Adcy4;PLCB3;GNB1;GNAI2 |
| Glutamatergic synapse | GRIN2B;GRIK1;GLS2;ITPR3;TRPC1;GRIK2;PLA2G4C;GRM6;SLC17A8 |
| Cholinergic synapse | CHRM1;CHRNB2;GNG7;GNG12;KCNQ4;CREB3;CAMK2B;GNG4;PLCB1 |
| Serotonergic synapse | CYP2J5;PRKACA;PTGS2;PLCB4;PRKACG;HTR1F;APP;HTR1B;CYP2C39 |
| GABAergic synapse | GNG12;GABARAPL1;GABRA6;HAP1;SLC38A2;GNB4;GABRB1;GPHN;GABRB2 |
| Dopaminergic synapse | MAPK9;PPP2R5B;CREB3L2;ITPR3;ARNTL;CALM4;CALM3;MAOA;PPP2R5D |
| Long-term depression | GRID2;PLA2G4D;GNAI3;PLCB1;MAPK3;PRKG2;GNAZ;PRKCB;MAP2K2 |
| Inflammatory mediator regulation of TRP channels | PRKACA;HRH1;TRPA1;P2RY2;PLCG2;ACCN3;IL1R1;CYP2C38;PIK3CB |
| Insulin secretion | VAMP2;GLP1R;RYR2;PDX1;ATP1A3;GNAS;GNAQ;ATP1B4;KCNN1 |
| GnRH signaling pathway | GNA11A;PRKACAA;PLA2G4A;MAP2K2A;CALM2B;PRKCA;CACNA1C;CAMK2D1;PRKCDA |
| Melanogenesis | PRKACBB;WNT16;CALM3A;CAMK2D1;EDNRB2;FZD8;GNA11A;PRKCA;WNT5A |
| Thyroid hormone synthesis | PLCB3;PDIA4;ATP1B4;GPX2;GSR;PLCB1;CREB5;ITPR1;PRKACA |
| Thyroid hormone signaling pathway | PLCE1;HRAS;NOTCH3;PIK3R5;ESR1;PRKCB;KAT2A;MAPK1;PLCD1 |
| Oxytocin signaling pathway | NFATC1;PRKCG;RGS2;SRC;CACNB2;PPP1CA;PIK3R1;PIK3CG;GNAS |
| Aldosterone synthesis and secretion | PRKACA;HSD3B2;ATF6B;CALM1;CALM2;CAMK2B;CYP11A1;DAGLB;PRKACG |
| Aldosterone-regulated sodium reabsorption | ATP1B3;PIK3CB;PDPK1;IRS1;INS2;SCNN1G;PIK3R1;PIK3R3;ATP1A4 |
| Endocrine and other factor-regulated calcium reabsorption | KLK1B3;GNAQ;RAB11A;KLK2;PLCB2;KLK1B8;PLCB1;KLK1B11;ATP1B1 |
| Salivary secretion | PMAP-36;AMY1B;SLC9A1;CD38;VAMP2;PLCB1;FXYD2;BST1;PLCB3 |
| Gastric acid secretion | GNAI2;GNAS;KCNE2;ATP1A4;KCNJ15;SST;CAMK2G;PLCB4;ACTB |
| Pancreatic secretion | PLA2G1B;LOC780933;RAP1A;FXYD2;PNLIPRP1;ATP1B1;RAB3D;ATP1B2;ATP1A1 |
| Vibrio cholerae infection | ATP6V1G1;ATP6V1E1;ATP6V1A;KDELR3;PLCG1;ACTB;PRKACA;ATP6AP1;ERO1L |
| Pathogenic Escherichia coli infection | TUBA1C;PRKCA;NCK1;NCK2;ITGB1;TUBAL3;ARHGEF2;ACTB;ROCK2 |
| African trypanosomiasis | PRKCG;F2RL1;PRKCA;LAMA4;VCAM1;IDO1;APOA1;HBB;THOP1 |
| Amoebiasis | LAMA2;PRKCA;CTSG;SERPINB6;LAMB3;LAMC2;RAB7;C8B;PLCB1 |
| Hepatitis B | SMAD3;NRAS;STAT4;NFKB1;YWHAB;VDAC3;IFNA6;TLR4;PRKCB |
| Influenza A | MAPK8;BLB1;IRF3;CYCS;GSK3B;TMPRSS2;CCL5;HLA-DRB4;TNFRSF10A |
| Pathways in cancer | RELA;GLI3;Flt3l;TGFBR2;PTGER3;PRKCA;IGF1R;SPI1;LAMB1 |
| Proteoglycans in cancer | ARHGEF12;SMO;ARHGEF1;CBLB;ITPR1;CTTN;FN1;WNT5B;MTOR |
| MicroRNAs in cancer | CDC25A;PIM1;STAT3;DICER1;TNC;Casp3;IRS2;EFNA3;PLAU |
| Glioma | PIK3CA;KRAS;PLCG2;TGFA;CALM3;HRAS;TP53;RAF1;CAMK2D |
| Non-small cell lung cancer | ARAF;SOS1;STK4;PLCG1;FHIT;PRKCG;RAF1;PIK3R1;RXRA |
| Choline metabolism in cancer | DGKB;DGKD;MAPK8;SLC22A2;DGKA;RPS6KB1;WASF3;SLC22A1;MTOR |
Prkca has several biochemical functions, for example, ATP binding, calcium-dependent protein kinase C activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkca itself. We selected most functions Prkca had, and list some proteins which have the same functions with Prkca. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DHX32;ADCY7;SARS;DDX28;TSSK4;HIPK2;BCS1L;NEK1;NLRX1 |
| calcium-dependent protein kinase C activity | PRKCA;PRKCG;ALPK2;CCL3 |
| enzyme binding | DAOA;PUS7;CYP3A4;MDM4;PTPLAD2;SIRT1;JUN;PTEN;HIST1H2AE |
| histone kinase activity (H3-T6 specific) | PRKCBB;PRKCB;PRKCA |
| protein binding | BCL2L13;LMAN1;P4HB;CIB4;ZMYM5;CDHR1;DRD3;NTSR1;LDB3 |
| protein kinase C activity | PRKD2;PRKCHA;PRKCD;PRKCHB;PRKCQ;PRKCZ;PRKCG;PKN3;PRKCE |
| protein kinase activity | DYRK1A;RPS6KB2;SCYL2;CLK4B;MKNK2A;CDK1;CSNK1D;GC2;CDK5R1 |
| protein serine/threonine kinase activity | HIPK4;CAMK2G1;WNK1;TESK1;CDK16;PAK4;NEK10;RPS6KA2;BMPR1BB |
| zinc ion binding | TRIM43B;DNAJC21;PHF2;NEURL1AB;MNAT1;ZFAND5;ZDHHC5A;ZMYND11;ZCCHC17 |
Prkca has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkca here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkca.
EGFR; Sdc4; bzlf1_ebvb9; NCF1; numb; SDC4; ndb25_parsc; inaD; Jak2; GIPC1; EIF2S1; HSP90AB1; UBC; BRAF
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Customer Reviews (3)
Write a reviewWhen utilized in Western Blotting experiments, the PRKCA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.
I have successfully implemented the PRKCA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.
Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the PRKCA protein in various research studies.
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