Prkca

  • Official Full Name

    protein kinase C, alpha

  • Overview

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Synonyms

    PRKCA; protein kinase C, alpha; AAG6; PKCA; PRKACA; PKC-alpha; protein kinase C alpha type; PKC-A; aging-associated gene 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCA-1087H Recombinant Human Protein Kinase C, Alpha, GST-tagged Sf9 Insect Cell GST
Human PRKCA-347H Recombinant Human PRKCA Mammalian Cell His
Human PRKCA-398H Recombinant Human Protein Kinase C, Alpha, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCA-648H Recombinant Human Protein Kinase C, Alpha Insect Cell N/A
Human PRKCA-1301H Recombinant Human Protein Kinase C, Alpha, His-tagged E.coli His
Human PRKCA-58H Recombinant Human protein kinase C, Alpha, His-tagged Sf9 Insect Cell His
Human PRKCA-499HCL Recombinant Human PRKCA lysate HEK293 N/A
Human PRKCA-3962HF Active Recombinant Full Length Human PRKCA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-672(end)
Human PRKCA-3385HF Active Recombinant Full Length Human PRKCA Protein, GST-tagged Insect (sf21) GST 1-672(end)
Human PRKCA-011H Recombinant Human PRKCA Protein, GST-tagged Insect cell GST 1-672
Human PRKCA-3909H Recombinant Human PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRKCA-0187H Recombinant Human PRKCA Protein (A2-V672), Tag Free Insect Cell No tag A2-V672
Human PRKCA-0188H Recombinant Human PRKCA Protein (A2-V672), GST tagged Insect Cell GST A2-V672
Human PRKCA-3909H-B Recombinant Human PRKCA Protein Pre-coupled Magnetic Beads HEK293
Mouse PRKCA-13361M Recombinant Mouse PRKCA Protein Mammalian Cell His
Mouse Prkca-1971M Recombinant Mouse Prkca protein, His & S-tagged E.coli His/S Phe339~Phe597 (Accession # P20444)
Mouse PRKCA-7092M Recombinant Mouse PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKCA-7092M-B Recombinant Mouse PRKCA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PRKCA-3604R Recombinant Rhesus monkey PRKCA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRKCA-3422R Recombinant Rhesus Macaque PRKCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRKCA-3422R-B Recombinant Rhesus Macaque PRKCA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKCA-8136Z Recombinant Zebrafish PRKCA Mammalian Cell His
Chicken PRKCA-2032C Recombinant Chicken PRKCA Mammalian Cell His
Prkca-397X Recombinant Xenopus Prkca, GST-tagged, Active Sf9 Insect Cell GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Prkca Related Research Area

Prkca involved in several pathways and played different roles in them. We selected most pathways Prkca participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkca were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNA2D3;MAPK8A;GRB2A;RPS6KA1;GADD45BB;FGFR2;MKNK2A;DUSP16;MINK1
ErbB signaling pathwayPAK6;NRG2B;PIK3R5;PTK2AA;MAPK3;NCK2A;PAK2A;PLCG2;BAD
Ras signaling pathwayPRKACA;FGF12;PLA2G3;FGFR1;CSF1;ETS2;PLA2G1B;MET;BCL2L1
Rap signaling pathwayPRKCI;ITGA2B;FGF2;PLCG1;Pdgfa&Pdgfb;FGFR1;RASSF5;FGF19;IGF1
Calcium signaling pathwayADRA1BB;CCKAR;ERBB3A;CALM3B;ATP2A1;CHRNA7;PRKACAB;P2RX8;ITPR3
HIF- signaling pathwayIL6;CAMK2G;GAPDH;MKNK1;MTOR;EGLN1;EP300;HMOX1;NOS3
Phosphatidylinositol signaling systemPTEN;PLCD1B;PIK3R3A;MTMR8;MTMR6;INPP5KA;MTMR1;PIP4K2C;IPPK
Sphingolipid signaling pathwayPIK3CA;ASAH2;S1PR5;SMPD1;NSMAF;PLCB3;PRKCB;S1PR4;S1PR2
Phospholipase D signaling pathwayINS2;PLCG1;AVPR1A;ARF6;AGPAT3;GRM8;GRM1;AKT1;PDGFD
mTOR signaling pathwayRRAGCB;PTEN;PIK3R2;ULK1;CAB39;PRKCG;RPS6KA3A;IRS1;AKT1
PIK-Akt signaling pathwayIL2RG;PIK3R2;PPP2R2A;LAMA2;COL24A1;PRL;HSP90B1;GNGT1;NGFR
Adrenergic signaling in cardiomyocytesPIK3R3;PPP1CAB;ATP1A1B;CREM;TPM4;MAPK14B;ATP1B3;CACNB4A;PLCB4
Vascular smooth muscle contractionCALML5;CALM1B;PRKCBB;CALM3;RAF1B;PRKCA;RHOAD;PLCB2;ROCK1
Wnt signaling pathwayTRP53;SFRP2;WNT1;AXIN2;CUL1A;FZD7;RAC1A;DVL1B;WNT2BB
VEGF signaling pathwayPTK2AB;PIK3CB;HRASA;PIK3R3B;PLA2G4D;SRC;PRKCB;MAPKAPK3;RAC1B
Focal adhesionIGF1RB;COL6A2;AKT3A;COL11A2;LAMA4;PAK1;FYNA;PRKCG;PPP1CB
Tight junctionCSNK2A2A;MYLPFA;CLDN7B;ACTN3A;CDC42L2;RAB3B;AKT2;PARD6A;ACTB2
Gap junctionPRKG1;PRKACBB;GJA1;PRKG1A;MAPK1;RAF1A;TUBA4A;PLCB4;DRD2A
Natural killer cell mediated cytotoxicityPTPN11;SHC2;IFNA2;IFNB1;PTK2B;IFNA13;H60a;KIR2DS5;FCGR3B
Fc epsilon RI signaling pathwayPIK3CG;TNF;PLA2G4A;PLCG2;PIK3R2;RAC1;PIK3CB;AKT2;LAT
Fc gamma R-mediated phagocytosisDOCK2;MAP2K1;PIK3R3;GAB2;LAT;WASF2;ASAP1;PPAP2C;PLA2G6
Leukocyte transendothelial migrationMYL9;CLDN17;PIK3CG;VAV2;MLLT4;JAM2;PIK3R2;CLDN1;BCAR1
Circadian entrainmentGNAI2;MTNR1A;GRIA1;PER2;CALM2;PLCB2;MTNR1B;CALM4;PRKG2
Long-term potentiationPPP3CB;PRKCA;CALM3;GRM1;RAF1;ATF4;PPP1CC;PRKACG;RPS6KA3
Retrograde endocannabinoid signalingGNAI2;GABRA2;GNB1;PLCB3;GNG12;SLC17A8;GABRA3;GABRG3;MAPK8
Glutamatergic synapseHOMER1;PLD2;HOMER2;GRIN1;SHANK1;PRKCA;GNB3;GNB1;SLC38A2
Cholinergic synapseGNB2;KCNJ3;MAP2K1;FOS;SLC5A7;PIK3R5;CAMK2B;CHRNA4;PIK3CA
Serotonergic synapseALOX15;CYP2D26;PLA2G4A;GNGT2;TPH2;ALOX8;CYP2J6;GNAI3;GNG10
GABAergic synapseGABRE;GNAI2;GNG7;GABRR2;GNG3;GABRB1;GABRD;PRKACB;GABRG2
Dopaminergic synapseCAMK2G;ITPR1;GNB3;PPP2R3C;CREB3L1;GNG12;CREB3L3;GNAI2;GNG7
Long-term depressionIGF1R;IGF1;GNAZ;GNA11;ITPR3;ARAF;KRAS;LYN;PRKG1
Inflammatory mediator regulation of TRP channelsPRKCB;ITPR1;HTR2A;IL1B;CAMK2D;CYP2J5;HTR2C;ACCN3;TRPV1
Insulin secretionCREB3L3;GLP1R;CAMK2B;KCNN1;GIP;PCLO;SLC2A1;CREB3L2;PRKCG
GnRH signaling pathwayCACNA1D;PLA2G4D;ADCY1A;ADCY1B;CDC42;MAP2K7;MAP3K2;HBEGFA;PRKACA
MelanogenesisFZD3B;PRKCB;CALM3;ADCY1A;PRKCBB;CALM4;CALM1;Fzd4;MAPK1
Thyroid hormone synthesisATP1A4;PDIA4;ATP1B2;ITPR1;TSHB;ASGR2;GPX1;LRP2;Adcy4
Thyroid hormone signaling pathwayPRKCB;PLCB4;SLCO1C1;MAP2K2;PRKCG;MED1;DIO1;PFKP;NCOR1
Oxytocin signaling pathwaySRC;CACNB2;CAMK2D;RCAN1;PIK3R1;PIK3CG;PRKACG;CACNA2D2;CCND1
Aldosterone synthesis and secretionAGTR1B;CALM3;GNA11;HSD3B6;NPR1;CYP11A1;CYP21A1;CAMK1G;AGTR1
Aldosterone-regulated sodium reabsorptionSGK1;PRKCG;ATP1A2;ATP1B3;NEDD4L;ATP1A3;PIK3CA;PIK3R3;PRKCB
Endocrine and other factor-regulated calcium reabsorptionKLK1B26;TRPV5;GNAQ;KL;FXYD2;ATP1A4;ATP1B3;CALB1;PLCB3
Salivary secretionKCNN4;AMY1B;ATP1B3;GNAQ;SLC9A1;ATP1B1;CALML5;PRKG2;BST1
Gastric acid secretionCALM4;MYLK2;CAMK2B;ITPR1;KCNJ16;CALM2;PLCB4;CALML5;KCNJ10
Pancreatic secretionPRKCG;CELA3B;PLCB3;ATP2B1;PRSS3;TRPC1;PLA2G2F;PLA2G2A;CELA2A
Vibrio cholerae infectionATP6V1D;ACTB;ERO1L;ATP6V1H;ATP6V1C2;ATP6V0D1;PRKACG;ATP6V1B2;SEC61G
Pathogenic Escherichia coli infectionABL1;NCK2;TUBB7P;ARHGEF2;LY96;CDH1;CTTN;CDC42;ACTG1
African trypanosomiasisIL1B;IL18;IDO2;APOA1;IL1B2;MYD88;HBB-B2;IL10;TNF
AmoebiasisCOL1A2;C8B;PIK3CD;COL3A1;CTSG;IL12A;FN1;SERPINB2;CD1d1
Hepatitis BIFNA7;EP300;ELK1;MYD88;MAP2K2;Fasl;PRKCA;MAPK10;FAS
Influenza ARNASEL;TLR4;HLA-DOB;CASP1;BMA2;TLR7;IFNB;H2-AA;CCL2
Pathways in cancerTFG;MMP9;IGF1R;PLEKHG5;RB1;PRKACA;RASGRP3;EP300;LAMB4
Proteoglycans in cancerPAK1;PIK3R5;CAV1;TP53;FZD1;RRAS;PIK3R3;SDC1;PPP1R12B
MicroRNAs in cancerWNT3;SLC7A1;ZEB1;RAF1;GLS2;TRIM71;ZFPM2;EZR;IKBKB
GliomaKRAS;SHC3;PLCG2;PIK3CD;MDM2;CALM1;CALM3;GRB2;NRAS
Non-small cell lung cancerPIK3CG;FHIT;HRAS;MAP2K1;PIK3CA;TP53;PRKCA;PIK3CD;ALK
Choline metabolism in cancerPLCG1;PPAP2C;PDGFRB;WASF1;MAPK1;PLA2G4F;PLA2G4C;AKT1;PLA2G4B

Prkca has several biochemical functions, for example, ATP binding, calcium-dependent protein kinase C activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkca itself. We selected most functions Prkca had, and list some proteins which have the same functions with Prkca. You can find most of the proteins on our site.

Function Related Protein
ATP bindingHELB;UBE2G1A;SMARCA4;NLRP1;PIM1;EPHB1;MAP4K4;UBE2D4;FIGN
calcium-dependent protein kinase C activityPRKCA;PRKCG;CCL3;ALPK2
enzyme bindingYWHAB;PRKDC;NOTCH1;DNMT3L;TSPAN33;MARCH6;PIAS3;PARK7;PPP3CA
histone kinase activity (H3-T6 specific)PRKCBB;PRKCB;PRKCA
protein bindingRUSC1;SRM;WWTR1;HIF1AN;WASH1;DNAJB6;SIKE1;WSB1;CNOT3
protein kinase C activityPRKCI;PRKCQ;PKN3;PKN1;PRKCBB;PRKCB;PRKD2;PRKD3;PRKCHB
protein kinase activitySOX9;CDK11A;MAP2K1;GSG2;CSNK1G2B;MAP2K4B;PLK5;STK30;CDKL2
protein serine/threonine kinase activityMAPK12B;STK19;LIMK2;PSKH2;PLK4;MAPK14;DMPK;ADCK4;ROCK1
zinc ion bindingPAPLNB;ZBBX;RNF175;SPRYD5;ZDHHC19;PRICKLE1B;GTF2H2C_2;TRIM52;ZMAT3

Prkca has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkca here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkca.

EGFR; Sdc4; bzlf1_ebvb9; NCF1; numb; SDC4; ndb25_parsc; inaD; Jak2; GIPC1; EIF2S1; HSP90AB1; UBC; BRAF

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Customer Reviews (3)

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Reviews
03/12/2020

    When utilized in Western Blotting experiments, the PRKCA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

    10/16/2017

      I have successfully implemented the PRKCA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

      01/09/2016

        Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the PRKCA protein in various research studies.

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