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Official Full Name protein arginine methyltransferase 6
Background The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
Synonyms PRMT6; protein arginine methyltransferase 6; HMT1 hnRNP methyltransferase like 6 (S. cerevisiae) , HRMT1L6; protein arginine N-methyltransferase 6; FLJ10559; HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6; heterogeneous nu
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRMT6-044H Recombinant Human PRMT6 Protein, His-tagged Insect cell His
    Human PRMT6-001H Recombinant Human PRMT6 Protein, His-tagged Insect Cell His
    Human PRMT6-179H Recombinant Human PRMT6 Protein, GST-tagged E.coli GST
    Human PRMT6-1970H Recombinant Human PRMT6, GST-tagged E.coli GST
    Human PRMT6-2458HCL Recombinant Human PRMT6 cell lysate Human Cell N/A
    Human PRMT6-3002H Recombinant Human PRMT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRMT6-318H Recombinant Human PRMT6 Protein, His & FLAG-tagged HEK293 His/Flag
    Human PRMT6-453H Recombinant Human Protein Arginine Methyltransferase 6 E.coli N/A
    Human PRMT6-5044H Recombinant Human PRMT6 Protein, GST-tagged Wheat Germ GST
    Human PRMT6-653H Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged Human Cell Flag
    Mouse PRMT6-13420M Recombinant Mouse PRMT6 Protein Mammalian Cell His
    Mouse Prmt6-5134M Recombinant Mouse Prmt6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque PRMT6-3615R Recombinant Rhesus monkey PRMT6 Protein, His-tagged Mammalian Cell His
    Zebrafish PRMT6-7567Z Recombinant Zebrafish PRMT6 Mammalian Cell His
    Kit-1860 PRMT6 (HRMT1L6) Chemiluminescent Assay Kit N/A
    Kit-1861 PRMT6 (HRMT1L6) Homogeneous Assay Kit N/A

    PRMT6 involved in several pathways and played different roles in them. We selected most pathways PRMT6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes EHMT2; MBD3B; MORF4L1; PADI2; PRDM16; TADA3; KAT5; ELP4; ING5A; BRD8
    Chromatin organization RBB4L; CSRP2BP; PHF15; SMARCD1; KDM3A; C20orf20; KDM6B; KIAA1267; SAP130; KDM4D
    RMTs methylate histone arginines PBRM1; ARID2; PRMT5; SMARCD3B; SMARCC1B; SMARCB1A; COPRS; SMARCA4; SMARCB1B; SMARCD3

    PRMT6 has several biochemical functions, for example, chromatin binding, histone binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT6 itself. We selected most functions PRMT6 had, and list some proteins which have the same functions with PRMT6. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding CSNK2B; NAP1L2; MLL1; DNMT3A; EZH2; SMC3; JARID2; GATA2A; TOX4; TRIM37
    histone binding HIST2H4A; HIST1H4J; H3F3A; HINFP; HIST1H4C; JAK2; HIST1H4F; NCL; HIST1H3C; WDTC1
    histone methyltransferase activity SUZ12; PRMT2; PRMT6; PRDM13; EED; SUV39H1; PRMT1; EZH2; CARM1
    histone methyltransferase activity (H2A-R3 specific) PRMT6
    histone methyltransferase activity (H3-R2 specific) PRMT6
    histone methyltransferase activity (H4-R3 specific) PRMT7; PRMT8B; PRMT1; PRMT8; PRMT6
    histone-arginine N-methyltransferase activity PRMT8; PRMT6; PRMT3; CARM1; PRMT2; PRMT5; PRMT7
    protein binding SLC9A1; ACVR1; PRKDC; PHF20L1; IRAK4; PLUNC; FHL1; NUMB; TRPC2; SGPL1
    protein-arginine omega-N asymmetric methyltransferase activity CARM1; PRMT1; PRMT8B; PRMT8; PRMT6; PRMT2; PRMT3; PRMT7
    protein-arginine omega-N monomethyltransferase activity PRMT8B; PRMT7; PRMT8; PRMT6

    PRMT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT6.

    HMGA1; a8k932_human; s-adenosyl-l-methionine-1; HMGA2; PSMD11; DNALI1; SMAD9

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