• Official Full Name

    protein arginine methyltransferase 6

  • Background

    The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
  • Synonyms

    PRMT6; protein arginine methyltransferase 6; HMT1 hnRNP methyltransferase like 6 (S. cerevisiae) , HRMT1L6; protein arginine N-methyltransferase 6; FLJ10559; HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6; heterogeneous nu;
    • Type:
    • Assay Kits
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect cell
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • His|Flag
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-1861 PRMT6 (HRMT1L6) Homogeneous Assay Kit N/A
    Kit-1860 PRMT6 (HRMT1L6) Chemiluminescent Assay Kit N/A
    Human PRMT6-044H Recombinant Human PRMT6 Protein, His-tagged Insect cell His
    Human PRMT6-179H Recombinant Human PRMT6 Protein, GST-tagged E.coli GST
    Human PRMT6-2458HCL Recombinant Human PRMT6 cell lysate Human Cell N/A
    Human PRMT6-5044H Recombinant Human PRMT6 Protein, GST-tagged Wheat Germ GST
    Human PRMT6-001H Recombinant Human PRMT6 Protein, His-tagged Insect Cell His
    Human PRMT6-3002H Recombinant Human PRMT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRMT6-1970H Recombinant Human PRMT6, GST-tagged E.coli GST
    Human PRMT6-453H Recombinant Human Protein Arginine Methyltransferase 6 E.coli N/A
    Human PRMT6-653H Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged Human Cell Flag
    Human PRMT6-318H Recombinant Human PRMT6 Protein, His & FLAG-tagged HEK293 His/Flag
    Mouse PRMT6-13420M Recombinant Mouse PRMT6 Protein Mammalian Cell His
    Mouse PRMT6-7126M-B Recombinant Mouse PRMT6 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Prmt6-5134M Recombinant Mouse Prmt6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse PRMT6-7126M Recombinant Mouse PRMT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque PRMT6-3433R-B Recombinant Rhesus Macaque PRMT6 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque PRMT6-3615R Recombinant Rhesus monkey PRMT6 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PRMT6-3433R Recombinant Rhesus Macaque PRMT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish PRMT6-7567Z Recombinant Zebrafish PRMT6 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    PRMT6 involved in several pathways and played different roles in them. We selected most pathways PRMT6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymesKDM3A;PRMT7;KIAA1267;KDM5D;ACTL6A;KAT6A;PHF17;ELP4;GATAD2AB
    Chromatin organizationEPC1;MSL2;EHMT2;SAP30;KAT7;PRMT7;KDM7AB;CHD4A;PHF8

    PRMT6 has several biochemical functions, for example, chromatin binding, histone binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT6 itself. We selected most functions PRMT6 had, and list some proteins which have the same functions with PRMT6. You can find most of the proteins on our site.

    Function Related Protein
    chromatin bindingORC1L;CEBPB;GATA4;TFAM;KIAA0101;POLD1;KAT2A;HMGB3;MCM5
    histone methyltransferase activityCARM1;PRDM13;SUV39H1;SUZ12;EZH2;PRMT2;PRMT6;PRMT1;EED
    histone methyltransferase activity (H2A-R3 specific)
    histone methyltransferase activity (H3-R2 specific)
    histone methyltransferase activity (H4-R3 specific)PRMT8B;PRMT6;PRMT7;PRMT8;PRMT1
    histone-arginine N-methyltransferase activityPRMT8;PRMT3;CARM1;PRMT2;PRMT7;PRMT6;PRMT5
    protein bindingTRIM72;SMOC1;PIGK;EMX2;ZNF460;STYK1;HDAC6;AJUBA;WHSC1L1
    protein-arginine omega-N asymmetric methyltransferase activityPRMT6;PRMT2;PRMT7;CARM1;PRMT8B;PRMT8;PRMT3;PRMT1
    protein-arginine omega-N monomethyltransferase activityPRMT8B;PRMT8;PRMT7;PRMT6

    PRMT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT6.

    HMGA1; a8k932_human; s-adenosyl-l-methionine-1; HMGA2; PSMD11; DNALI1; SMAD9

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