PRMT6

  • Official Full Name

    protein arginine methyltransferase 6
  • Overview

    The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
  • Synonyms

    PRMT6;protein arginine methyltransferase 6;HMT1 hnRNP methyltransferase like 6 (S. cerevisiae) , HRMT1L6;protein arginine N-methyltransferase 6;FLJ10559;HMT1 hnRNP methyltransferase-like 6;histone-arginine N-methyltransferase PRMT6;heterogeneous nu

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • Human Cells
  • Insect Cells
  • GST
  • His
  • Flag
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRMT6-1970H Recombinant Human PRMT6, GST-tagged E.coli Human GST C-term-316aa
PRMT6-13420M Recombinant Mouse PRMT6 Protein Mammalian Cells Mouse His
PRMT6-179H Recombinant Human PRMT6 Protein, GST-tagged E.coli Human GST 2-375
PRMT6-318H Recombinant Human PRMT6 Protein, His & FLAG-tagged HEK293 Human Flag&His 1-375 a.a.
PRMT6-3615R Recombinant Rhesus monkey PRMT6 Protein, His-tagged Mammalian Cells Rhesus macaque His
PRMT6-453H Recombinant Human Protein Arginine Methyltransferase 6 E.coli Human Non 2-375 a.a.
PRMT6-5044H Recombinant Human PRMT6 Protein, GST-tagged Wheat Germ Human GST
PRMT6-653H Recombinant Human Protein Arginine Methyltransferase 6, Flag-tagged Human Cells Human Flag 1-375 a.a.
PRMT6-7567Z Recombinant Zebrafish PRMT6 Mammalian Cells Zebrafish His
PRMT6-2458HCL Recombinant Human PRMT6 cell lysate Human Cells Human Non
Kit-1860 PRMT6 (HRMT1L6) Chemiluminescent Assay Kit Non
Kit-1861 PRMT6 (HRMT1L6) Homogeneous Assay Kit Non
PRMT6-001H Recombinant Human PRMT6 Protein, His-tagged Insect Cells Human His
PRMT6-044H Recombinant Human PRMT6 Protein, His-tagged Insect Cells Human His
PRMT6-3002H Recombinant Human PRMT6 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
PRMT6-3433R Recombinant Rhesus Macaque PRMT6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
PRMT6-3433R-B Recombinant Rhesus Macaque PRMT6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Prmt6-5134M Recombinant Mouse Prmt6 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
PRMT6-7126M Recombinant Mouse PRMT6 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PRMT6-7126M-B Recombinant Mouse PRMT6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PRMT6 involved in several pathways and played different roles in them. We selected most pathways PRMT6 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes KDM6B,MSL3,RBBP7,PADI6,ACTL6A,GATAD2B,SMARCA2,VPS72,SMARCD1,C20orf20
    Chromatin organization KDM5C,ING4,MBD3A,PADI6,KDM5B,SUZ12A,EHMT2,PBRM1L,KANSL3,MSL1A
    RMTs methylate histone arginines SMARCC1B,ARID1A,SMARCC2,SMARCA4,SMARCA2,SMARCD1,SMARCD3B,ARID2,PRMT7,COPRS

    Protein Function

    PRMT6 has several biochemical functions, for example, chromatin binding,histone binding,histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT6 itself. We selected most functions PRMT6 had, and list some proteins which have the same functions with PRMT6. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding RDBP,POU1F1,PRKCBB,HDGF2,NUPR1,NR5A1A,WACA,ATOH1A,MITF,PRKCB
    protein binding RIN3,GGACT,GTF2E2,TPSAB1,MAPT,PHB2,HINFP,TTYH2,SDCCAG8,DNAJC15
    protein-arginine omega-N monomethyltransferase activity PRMT8,PRMT8B,PRMT7
    histone binding SMARCA2,H3F3B,HIST1H4F,SNCA,LEF1,Ctsl,RNF20,HIST4H4,HIST1H3G,UHRF1
    histone-arginine N-methyltransferase activity PRMT2,CARM1,PRMT5,PRMT7,PRMT3,PRMT8
    protein-arginine omega-N asymmetric methyltransferase activity PRMT3,PRMT8B,PRMT2,PRMT7,PRMT8,CARM1,PRMT1
    histone methyltransferase activity (H4-R3 specific) PRMT8B,PRMT1,PRMT8,PRMT7
    histone methyltransferase activity PRMT1,CARM1,PRDM13,PRMT2,SUV39H1,EZH2,SUZ12,EED

    Interacting Protein

    PRMT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT6.

    HMGA1;a8k932_human;s-adenosyl-l-methionine-1;HMGA2;PSMD11;DNALI1;SMAD9

    Resources

    References

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