PRMT6
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Official Full Name
protein arginine methyltransferase 6
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Background
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. -
Synonyms
PRMT6; protein arginine methyltransferase 6; HMT1 hnRNP methyltransferase like 6 (S. cerevisiae) , HRMT1L6; protein arginine N-methyltransferase 6; FLJ10559; HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6; heterogeneous nu;
- Involved Pathway
- Protein Function
- Interacting Protein
PRMT6 involved in several pathways and played different roles in them. We selected most pathways PRMT6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM3A;PRMT7;KIAA1267;KDM5D;ACTL6A;KAT6A;PHF17;ELP4;GATAD2AB |
| Chromatin organization | EPC1;MSL2;EHMT2;SAP30;KAT7;PRMT7;KDM7AB;CHD4A;PHF8 |
| RMTs methylate histone arginines | ARID2;PRMT7;SMARCE1;SMARCC1;SMARCA2;SMARCA4;ARID1A;SMARCC2;ACTL6B |
PRMT6 has several biochemical functions, for example, chromatin binding, histone binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT6 itself. We selected most functions PRMT6 had, and list some proteins which have the same functions with PRMT6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ORC1L;CEBPB;GATA4;TFAM;KIAA0101;POLD1;KAT2A;HMGB3;MCM5 |
| histone binding | JAK2;TBL1X;HIST1H3E;MYSM1;RNF168;HIST1H3H;SMARCA4A;HIST1H3F;UIMC1 |
| histone methyltransferase activity | CARM1;PRDM13;SUV39H1;SUZ12;EZH2;PRMT2;PRMT6;PRMT1;EED |
| histone methyltransferase activity (H2A-R3 specific) | |
| histone methyltransferase activity (H3-R2 specific) | |
| histone methyltransferase activity (H4-R3 specific) | PRMT8B;PRMT6;PRMT7;PRMT8;PRMT1 |
| histone-arginine N-methyltransferase activity | PRMT8;PRMT3;CARM1;PRMT2;PRMT7;PRMT6;PRMT5 |
| protein binding | TRIM72;SMOC1;PIGK;EMX2;ZNF460;STYK1;HDAC6;AJUBA;WHSC1L1 |
| protein-arginine omega-N asymmetric methyltransferase activity | PRMT6;PRMT2;PRMT7;CARM1;PRMT8B;PRMT8;PRMT3;PRMT1 |
| protein-arginine omega-N monomethyltransferase activity | PRMT8B;PRMT8;PRMT7;PRMT6 |
PRMT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT6.
HMGA1; a8k932_human; s-adenosyl-l-methionine-1; HMGA2; PSMD11; DNALI1; SMAD9
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