PROK1

Official Full Name

prokineticin 1
Overview

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner.
Synonyms

EG-VEGF; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; PROK1; PROK1_HUMAN; Prokineticin-1; prokineticin 1; PK1; PRK1; EGVEGF;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
GMP Proteins

Species

Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Insect Cell
Insect Cells
Mammalian Cell
Mammalian cells

Tag

Fc
His
Avi
GST
SUMO
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PROK1-335H	Recombinant Human Prokineticin 1	Mammalian cells	Non		Inquiry
Human	PROK1-8458H	Active Recombinant Human PROK1	Mammalian cells	Non		Inquiry
Human	PROK1-592H	Recombinant Human PROK1 protein, His & GST-tagged	E.coli	His&GST	Met1~Phe105	Inquiry
Human	PROK1-7517H	Recombinant Human PROK1 protein, His-tagged	Insect Cells	His	Met1-Phe105	Inquiry
Human	PROK1-43H	Recombinant Human PROK1 protein	E.coli	Non	86	Inquiry
Human	PROK1-001HCL	Recombinant Human PROK1 cell lysate	Insect Cell	Non		Inquiry
Human	PROK1-230H	Recombinant Human PROK1 Protein	E.coli			Inquiry
Human	PROK1-4476H	Recombinant Human PROK1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	PROK1-4476H-B	Recombinant Human PROK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Prok1-396M	Active Recombinant Mouse Prokineticin 1	Mammalian cells	Non	Ala20-Phe105	Inquiry
Mouse	PROK1-13430M	Recombinant Mouse PROK1 protein	E.coli	Non	86	Inquiry
Mouse	Prok1-1200M	Recombinant Mouse Prok1 Protein, His&SUMO-tagged	E.coli	His&SUMO	Met1-Phe105	Inquiry
Mouse	Prok1-10610M-B	Recombinant Mouse Prok1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Prok1-078MG	Active GMP Recombinant Mouse Prok1 protein, Fc-tagged	HEK293	Fc	DNA sequence encoding Mouse EG-VEGF(NCBI: NP_001037847.1) was expressed with Fc tag at the C-terminal.	Inquiry
Mouse	Prok1-10610M	Recombinant Mouse Prok1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	PROK1-4712R	Recombinant Rat PROK1 Protein	Mammalian Cell	His		Inquiry
Rat	PROK1-4371R	Recombinant Rat PROK1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	PROK1-4371R-B	Recombinant Rat PROK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PROK1-3618R	Recombinant Rhesus monkey PROK1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PROK1-3436R	Recombinant Rhesus Macaque PROK1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	PROK1-3436R-B	Recombinant Rhesus Macaque PROK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	PROK1-6036Z	Recombinant Zebrafish PROK1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PROK1 involved in several pathways and played different roles in them. We selected most pathways PROK1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	TRH;PROKR1A;EDN3;S1PR1;ZFPM2B;GPR37L1;AGTR1;CCL27;PNOCB
G alpha (q) signalling events	GPRC6A;CCK;OPN4B;RGS18;EDNRAB;PROK2;PMCH;RASGRP2;AGTR1
GPCR downstream signaling	CNR1;ARHGEF3;NMB;PROKR2;ANXA1C;OBSCN;NPFFR2;PRKCHB;ARHGEF1A
GPCR ligand binding	EMR3;GPR132B;CALCA;INSL5;CRHR1;APLNR;CCL35.1;OXTRL;DRD4
Gastrin-CREB signalling pathway via PKC and MAPK	NMU;EDN1;TAC1;UTS2D;OXTRL;GCGB;NMBB;TAC2;DGKQ
Peptide ligand-binding receptors	RLN3;ZFPM2B;EDNRAB;RLN3A;TAC2;FPR-RS6;APLNR;NPS;SSTR1
Signal Transduction	DRAP1;PENKB;RGS1;RNF146;ABI1B;KIF7;SST1.1;NMBB;ARHGAP17A
Signaling by GPCR	GPR55A;TAS2R3;GAL;FGD4;RGS17;INSL3;RAMP3;PTHLH;CXCR7B

PROK1 has several biochemical functions, for example, G-protein coupled receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROK1 itself. We selected most functions PROK1 had, and list some proteins which have the same functions with PROK1. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor binding	GNAI2A;RSPO1;HAND2;ITGB4;USP33;RLN3;GNAT3;NPFF;GPRC5B
growth factor activity	FGF3;ENDOU;BMP7;BMP10;CTGF;NDR2;TIMP1;GH1;PROK1

PROK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROK1.