PROS1
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Official Full Name
protein S (alpha)
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Overview
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009] -
Synonyms
PROS1; protein S (alpha); PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; vitamin K-dependent protein S; protein Sa; vitamin K-dependent plasma protein S;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Plasma
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- PROS1 Related Research Area
PROS1 involved in several pathways and played different roles in them. We selected most pathways PROS1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C1RA;C6;CFH;MASP2;GM5077;C9;C4A;PROC;C8A |
PROS1 has several biochemical functions, for example, calcium ion binding, endopeptidase inhibitor activity, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PROS1 itself. We selected most functions PROS1 had, and list some proteins which have the same functions with PROS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CDH4;NOTCH4;TBC1D9;CELSR2;MMP30;PKD1L3;TBC1D9B;SRR;PCDHB13 |
| endopeptidase inhibitor activity | RENBP;CST3;MUG2;ITIH2;SERPINA1A;SERPINA1E;Serpina1c;SERPINA1D;PSMF1 |
| protein complex binding | Casp3;LRP2;RARB;BAG3;VPS28;ABP1;DLG4;MYC;CDKN1B |
PROS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROS1.
RPSA; purL; TBK1; d-mannose
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