| Description : |
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75.1 kDa |
| AA Sequence : |
MRVLGGRCGALLACLLLVLPVSEAN FLSKQQASQVLVRKRRANSLLEETK QGNLERECIEELCNKEEAREVFEND PETDYFYPKYLVCLRSFQTGLFTAA RQSTNAYPDLRSCVNAIPDQCSPLP CNEDGYMSCKDGKASFTCTCKPGWQ GEKCEFDINECKDPSNINGGCSQIC DNTPGSYHCSCKNGFVMLSNKKDCK DVDECSLKPSICGTAVCKNIPGDFE CECPEGYRYNLKSKSCEDIDECSEN MCAQLCVNYPGGYTCYCDGKKGFKL AQDQKSCEVVSVCLPLNLDTKYELL YLAEQFAGVVLYLKFRLPEISRFSA EFDFRTYDSEGVILYAESIDHSAWL LIALRGGKIEVQLKNEHTSKITTGG DVINNGLWNMVSVEELEHSISIKIA KEAVMDINKPGPLFKPENGLLETKV YFAGFPRKVESELIKPINPRLDGCI RSWNLMKQGASGIKEIIQEKQNKHC LVTVEKGSYYPGSGIAQFHIDYNNV SSAEGWHVNVTLNIRPSTGTGVMLA LVSGNNTVPFAVSLVDSTSEKSQDI LLSVENTVIYRIQALSLCSDQQSHL EFRVNRNNLELSTPLKIETISHEDL QRQLAVLDKAMKAKVATYLGGLPDV PFSATPVNAFYNGCMEVNINGVQLD LDEAISKHNDIRAHSCPSVWKKTKN STRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
