PRPF6

  • Official Full Name

    PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)

  • Overview

    The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.

  • Synonyms

    PRPF6;PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae);C20orf14, chromosome 20 open reading frame 14 , PRP6 pre mRNA processing factor 6 homolog (yeast);pre-mRNA-processing factor 6;ANT 1;bB152O15.1;Prp6;TOM;U5 102K;Androgen receptor N terminal domain transactivating protein 1;Chromosome 20 open reading frame 14;fc12b02;hypothetical protein LOC323855;p102 U5 small nuclear ribonucleoprotein particle binding protein;Pre mRNA processing factor 6;PRP6 homolog;PRPF 6;Putative mitochondrial outer membrane protein import receptor;U5 102 kDa protein;U5 snRNP associated 102 kDa protein;wu:fa05f07;wu:fc12b02;zgc:65913;U5-102 kDa protein;U5 snRNP-associated 102 kDa protein;androgen receptor N-terminal domain transactivating protein-1;androgen receptor N-terminal domain-transactivating protein 1;p102 U5 small nuclear ribonucleoprotein particle-binding protein;ANT1;ANT-1;hPrp6;U5-102K;C20orf14

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    PRPF6 involved in several pathways and played different roles in them. We selected most pathways PRPF6 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Spliceosome FAM120B,TXNL4A,HNRNPA1,SNRPD2,PRPF18,SARNP,PCBP1,SNRNP40,SF3B3,HSC70

    Protein Function

    PRPF6 has several biochemical functions, for example, RNA binding,androgen receptor binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF6 itself. We selected most functions PRPF6 had, and list some proteins which have the same functions with PRPF6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GNG4,RRM2,TUB,RBM23,MAGEC2,EPHA4,CHMP5,ZNF16,CRTC2,SEPHS1
    RNA binding NUFIP2,ELAVL4,THUMPD2,IFIT14,ELAVL1,CWC15,NOL3,FAM120A,METTL14,PATL2
    androgen receptor binding KDM4C,NSD1,FHL2,GRIP1,PIAS1,PRMT2,TCF21,RNF4,NCOA4,PIAS2
    poly(A) RNA binding XRCC5,CPSF6,MKI67IP,DARS,CPSF7,C1orf35,EZR,SNRPA,GTF2E2,SAMD4A
    transcription coactivator activity PDLIM1,LPIN2,GATA4,ZEB1,SUB1A,NFE2,MED27,PSMD9,MAML2,USP16
    ribonucleoprotein complex binding PITX2,SECISBP2,ITCH,BOP1,PIGC,TIMM50,SRP54A,WDR12,RNF135,YBX2

    Interacting Protein

    PRPF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF6.

    CD2BP2;MYC;PRPF4;RNPS1;IK;PRPF31;a8k1f4_human;SNRPB;SMARCA2;MDM2

    Resources

    References

    • Bhatia, V; Barroso, SI; et al. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. NATURE 511:362-+(2014).
    • Derer, S; Till, A; et al. mTNF reverse signalling induced by TNF alpha antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. GUT 62:376-386(2013).

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