PSMB2
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Official Full Name
proteasome (prosome, macropain) subunit, beta type, 2
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Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
PSMB2; proteasome (prosome, macropain) subunit, beta type, 2; proteasome subunit beta type-2; HC7 I; macropain subunit C7-I; proteasome beta 2 subunit; proteasome component C7-I; proteasome subunit, beta type, 2; multicatalytic endopeptidase complex subun;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PSMB2 involved in several pathways and played different roles in them. We selected most pathways PSMB2 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMC1A;PSMA1;PSMB4;PSMB2;PSMB5;PSMC1B;PSMC1;PSME2;PSMD2 |
PSMB2 has several biochemical functions, for example, endopeptidase activity, protein binding, threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMB2 itself. We selected most functions PSMB2 had, and list some proteins which have the same functions with PSMB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSMB7;CPS1;PSMB8;KLK1B5;PSMB2;F9;KLK1B3;MMP1;SENP1 |
| protein binding | DYNLT3;SF3A3;PRDM4;TXNDC11;GPRASP2;CSGALNACT2;CHERP;DLG4;LDLR |
| threonine-type endopeptidase activity | PSMB4;PSMB9;PSMA4;PSMA2;PSMA1;PSMA6;PSMA8;PSMA3;PSMA5 |
PSMB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMB2.
KRT13; KCTD9; PSMA1; PSMB3; VCAM1; UCHL5; TRAF6
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