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Official Full Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Synonyms PSMD4; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; 26S proteasome non-ATPase regulatory subunit 4; AF; AF 1; Rpn10; S5A; angiocidin; RPN10 homolog; antisecretory factor 1; S5a/antisecretory factor protein; multiubiquitin chain-binding prot
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PSMD4-550H Recombinant Human PSMD4, Myc/DDK-tagged HEK293T Myc/DDK
    Human PSMD4-018H Recombinant Human PSMD4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human PSMD4-152H Recombinant Human PSMD4, GST-tagged E.coli GST
    Human PSMD4-183H Recombinant Human PSMD4, His-tagged HEK293 His
    Human PSMD4-2031H Recombinant Human PSMD4, His-tagged E.coli His
    Human PSMD4-2748HCL Recombinant Human PSMD4 293 Cell Lysate HEK293 N/A
    Human PSMD4-422H Recombinant Human PSMD4 Protein, His/GST-tagged E.coli His/GST
    Human PSMD4-548H Recombinant Human PSMD4 Mammalian Cell His
    Mouse PSMD4-13595M Recombinant Mouse PSMD4 Protein Mammalian Cell His
    Mouse Psmd4-5195M Recombinant Mouse Psmd4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque PSMD4-3672R Recombinant Rhesus monkey PSMD4 Protein, His-tagged Mammalian Cell His
    Chicken PSMD4-3892C Recombinant Chicken PSMD4 Mammalian Cell His

    psmd4 involved in several pathways and played different roles in them. We selected most pathways psmd4 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with psmd4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome PSMD13; PSMB11; PSMD4B; PSMD4A; PSMB8; PSMD3; PSMB10; PSMD2; PSMD6; PSMB6
    Epstein-Barr virus infection TBK1; PTMA; HLA-A; LYN; TRAF1; YWHAZ; POLR2J3; HLA-DRB1; POLR2B; NFKBIB

    psmd4 has several biochemical functions, for example, identical protein binding, poly(A) RNA binding, polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by psmd4 itself. We selected most functions psmd4 had, and list some proteins which have the same functions with psmd4. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding LYZ1; PSMD4; SFRP1; PLN; RPE; CRYBB2; DHX8; MCPH1; DYNLT1F; MCM6
    poly(A) RNA binding NOL11; DHX36; TPD52L2; TNS1; SEC23IP; NOP58; NSBP1; MRPL40; PABPC1; NSUN5
    polyubiquitin binding RAD18; VCP; UBQLN1; RAD23B; DNAJB2; FAM175B; AGL; RAD23A; BRCC3; BAG6
    protein binding FAAH; CACNG2; UCP3; LIMS3L; YAP1; MUS81; AGPAT4; EP400; ARHGEF38; POLRMT
    transcription factor binding MYBBP1A; SMAD2; TBL1X; PYDC3; NFATC2; CSNK2B; RPS3; AHR; IGHMBP2; TFDP2

    psmd4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with psmd4 here. Most of them are supplied by our site. Hope this information will be useful for your research of psmd4.

    UBC; RAD23B

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