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PTCH1

  • Official Full Name

    patched homolog 1

  • Overview

    Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
  • Synonyms

    PTC1; A230106A15Rik; BCNS; FLJ26746; FLJ42602; Holoprosencephaly 7; HPE7; mes; NBCCS; OTTHUMP00000021709; OTTHUMP00000021710; Patched; Patched (Drosophila) homolog; Patched 1; Patched homolog (Drosophila); Patched homolog 1 (Drosophila); Patched homolog 1; Patched protein homolog 1; Protein patched homolog 1; PTC; PTC1_HUMAN; PTCH; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein; PTCH1; PTCH1 protein; PTCH11; Ptch2; Patched Tumor Suppressor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • DDK
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTCH1-29531TH Recombinant Human PTCH1 Wheat Germ N/A 100 amino acids
Human PTCH1-414H Recombinant Human PTCH1 Protein, DDK-tagged Insect Cell DDK Met-Arg770-Trp1027
Human PTCH1-2723HCL Recombinant Human PTCH1 293 Cell Lysate HEK293 N/A
Human PTCH1-6056H Recombinant Human PTCH1 Protein (Glu122-Leu249), N-His tagged E.coli N-His Glu122-Leu249
Human PTCH1-1772H Recombinant Human PTCH1 protein, His-tagged E.coli His Leu227~Asp436
Mouse PTCH1-13624M Recombinant Mouse PTCH1 Protein Mammalian Cell His
Mouse Ptch1-1773M Recombinant Mouse Ptch1 protein, His & T7-tagged E.coli His/T7 Leu213~Asp422 (Accession # Q61115)
Mouse PTCH1-7243M Recombinant Mouse PTCH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTCH1-7243M-B Recombinant Mouse PTCH1 Protein Pre-coupled Magnetic Beads HEK293
Chicken PTCH1-6519C Recombinant Chicken PTCH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTCH1 Related Articles
  • PTCH1 Related Research Area

PTCH1 involved in several pathways and played different roles in them. We selected most pathways PTCH1 participated on our site, such as cAMP signaling pathway, Hedgehog signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTCH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayCAMK2G;TNNI3;GPR119;GRIN2C;HTR1E;ATP2B4;ATP1A3;HTR1B;ATP1A4
Hedgehog signaling pathwayFBXW11B;PRKACB;WNT16;ZIC2B;WNT10B;GLI2B;RAB23;WNT3;SKIA
Pathways in cancerBIRC2;MSH6;MAPK3;ARNT2;DAPK3;PRKCB;CTBP2;RALGDS;GLI1
Proteoglycans in cancerTGFB2;PPP1CC;ITPR1;PTCH1;SDC2;TIMP3;SLC9A1;PTK2;CBLB
Basal cell carcinomaTP53;WNT3;FZD10;Shh;FZD3;FZD9;WNT5A;DVL1;STK36

PTCH1 has several biochemical functions, for example, cholesterol binding, cyclin binding, hedgehog family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTCH1 itself. We selected most functions PTCH1 had, and list some proteins which have the same functions with PTCH1. You can find most of the proteins on our site.

Function Related Protein
cholesterol bindingSTAR;OSBPL5;APOA2;APOA1;NR1H3;APOE;PMP2;APOA4B.2;ANXA6
cyclin bindingCDK5RAP3;CDK13;CDK2;CUL3;PTCH1;HDAC3;CDK14;PFTK1;CDK6
hedgehog family protein bindingHHIP;PTCH1;PTCH2
hedgehog receptor activityPTCHD1;DISP1;PTCHD3;PTCH1;PTCH2;NPC1;PTCHD4;B9D1
heparin bindingFGF10;SFRP1;CLEC3B;ADAMTS8;NRP2;AAMP;THBS4;BSPH1;C6orf25
patched bindingIHH;DHH;SMO;PTCH1;CCNB1;SETD6;BBS1;Shh;CAV1
protein bindingKIAA1109;ETV6;GPR50;BCL11B;MIS18A;CBX3;HOOK1;IGF2BP1;RAB5B
protein complex bindingPDX1;KAT2B;PPIB;RBX1;RAN;CPS1;TUBB;DAG1;LRRC16A
smoothened bindingPTCH1;PTCH2;BBS1

PTCH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTCH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTCH1.

YAP1; SMO; g3h9i8_crigr

Alfaro, AC; Roberts, B; et al. Ptch2 mediates the Shh response in Ptch1(-/-) cells. DEVELOPMENT 141:3331-3339(2014).
Abiria, SA; Williams, TV; et al. Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling. JOURNAL OF NEURO-ONCOLOGY 119:243-251(2014).
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