PTCH1
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Official Full Name
patched homolog 1 -
Overview
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. -
Synonyms
PTC1;A230106A15Rik;BCNS;FLJ26746;FLJ42602;Holoprosencephaly 7;HPE7;mes;NBCCS;OTTHUMP00000021709;OTTHUMP00000021710;Patched;Patched (Drosophila) homolog;Patched 1;Patched homolog (Drosophila);Patched homolog 1 (Drosophila);Patched homolog 1;Patched protein homolog 1;Protein patched homolog 1;PTC;PTC1_HUMAN;PTCH;PTCH protein +12b;PTCH protein +4';PTCH protein -10;PTCH protein;PTCH1;PTCH1 protein;PTCH11;Ptch2;Patched Tumor Suppressor
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- E.coli
- His
- Non
- Flag
- T7
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTCH1-13624M | Recombinant Mouse PTCH1 Protein | Mammalian Cells | Mouse | His |
|
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| PTCH1-29531TH | Recombinant Human PTCH1 | Wheat Germ | Human | Non | 100 amino acids |
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| PTCH1-414H | Recombinant Human PTCH1 Protein, DDK-tagged | Insect Cells | Human | Flag | Met-Arg770-Trp1027 |
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| PTCH1-6519C | Recombinant Chicken PTCH1 | Mammalian Cells | Chicken | His |
|
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| PTCH1-2723HCL | Recombinant Human PTCH1 293 Cell Lysate | HEK293 | Human | Non |
|
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| PTCH1-1772H | Recombinant Human PTCH1 protein, His-tagged | E.coli | Human | His | Leu227~Asp436 |
|
| Ptch1-1773M | Recombinant Mouse Ptch1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Leu213~Asp422 |
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| PTCH1-6056H | Recombinant Human PTCH1 Protein (Glu122-Leu249), N-His tagged | E.coli | Human | His | Glu122-Leu249 |
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| PTCH1-7243M | Recombinant Mouse PTCH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PTCH1-7243M-B | Recombinant Mouse PTCH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PTCH1 involved in several pathways and played different roles in them. We selected most pathways PTCH1 participated on our site, such as cAMP signaling pathway,Hedgehog signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTCH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | ITGB3,CBLB,PTK2,HOXD10,HIF1A,WNT3,WNT16,IL12B,KRAS,GAB1 |
| Basal cell carcinoma | DVL1,Shh,FZD7,Fzd4,WNT16,GLI2,FZD5,BMP4,FZD2,FZD3 |
| Hedgehog signaling pathway | IHH,BMP4,LRP2,GAS1,GLI3,PRKACA,WNT9B,CSNK1G2A,GLI2,SAP18 |
| cAMP signaling pathway | GRIN2A,PDE4D,GLI1,FFAR2,GABBR2,RRAS2,EP300,ROCK2,MAPK8,HCAR3 |
| Pathways in cancer | GNAI1,PTK2,ITGA3,RXRB,FGF1,PIK3R3,ITGA6,SUFU,MAPK3,PIK3CD |
Protein Function
PTCH1 has several biochemical functions, for example, cholesterol binding,cyclin binding,hedgehog family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTCH1 itself. We selected most functions PTCH1 had, and list some proteins which have the same functions with PTCH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | RXRA,RBM10,CDK5RAP2,VPS28,CPD,CDK4,PRKACA,CDKN1B,PAFAH1B1,PDCL |
| patched binding | CAV1,BBS1,SETD6,IHH,SMO,DHH,CCNB1,Shh |
| hedgehog family protein binding | HHIP,PTCH2 |
| smoothened binding | PTCH2,BBS1 |
| heparin binding | VEGFB,TGFBR3,MDK,GREM2,Itgam&Itgb2,ABP1,NAV2,NRP1A,RSPO1,CRISPLD2 |
| hedgehog receptor activity | NPC1,PTCHD1,PTCHD3,PTCH2,PTCHD4,B9D1,DISP1 |
| cyclin binding | CDKN1A,CDK6,CDK2,HDAC3,CDK4,PFTK1,INCA1,CUL3,FBXW7,CDK5RAP3 |
| cholesterol binding | CYP11A1,TSPO2,STAR,NR1H3,OSBPL3,SYP,OSBPL2,STARD6,OSBPL8,APOEA |
| protein binding | PEX10,TAF1C,PFKFB1,UPK3A,BLM,MMS19,KIF22,CASR,TNK2,NCOA2 |
Interacting Protein
PTCH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTCH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTCH1.
YAP1;SMO;g3h9i8_crigr
Resources
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References
- Alfaro, AC; Roberts, B; et al. Ptch2 mediates the Shh response in Ptch1(-/-) cells. DEVELOPMENT 141:3331-3339(2014).
- Abiria, SA; Williams, TV; et al. Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling. JOURNAL OF NEURO-ONCOLOGY 119:243-251(2014).
