PTK6

  • Official Full Name

    PTK6 PTK6 protein tyrosine kinase 6

  • Overview

    The expression of protein-tyrosine-kinase 6 (PTK6, BRK-breast cancer related kinase) is restricted to normal differentiating epithelial cells. PTK6/BRK is overexpressed in many breast and ovarian cancer cell lines and the expression level is associated with poor prognosis.
  • Synonyms

    PTK6; PTK6 protein tyrosine kinase 6; protein-tyrosine kinase 6; BRK; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK; FLJ42088;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTK6-708HFL Active Recombinant Full Length Human PTK6 Protein, C-Flag-tagged Mammalian cells Flag
Human PTK6-28HFL Active Recombinant Full Length Human PTK6 Protein, N-His-tagged Sf21 His Full Length
Human PTK6-254H Recombinant Human PTK6 Protein Tyrosine Kinase 6, GST-tagged, Active Sf9 Insect Cell GST
Human PTK6-1188H Recombinant Human PTK6 protein, His & T7-tagged E.coli His/T7 Phe191~Thr445 (Accession # Q13882)
Human PTK6-1905H Recombinant Human PTK6 Protein Tyrosine Kinase 6, His-tagged Insect Cell His
Human PTK6-919H Recombinant Human PTK6 protein, GST-tagged Insect Cells GST Met1-Thr451
Human PTK6-709HCL Recombinant Human PTK6 cell lysate Insect Cell N/A
Human PTK6-3978HF Active Recombinant Full Length Human PTK6 Protein, GST-tagged Insect (sf21) GST 2-451(end)
Human PTK6-0760H Recombinant Human PTK6 Protein (V2-T451), His/GST tagged Insect Cell His/GST V2-T451
Human PTK6-3109H Recombinant Human PTK6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTK6-6082H Recombinant Human PTK6 Protein (Phe191-Thr445), N-His tagged E.coli N-His Phe191-Thr445
Human PTK6-8516HF Active Recombinant Full Length Human PTK6 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 2-451(end)
Human PTK6-2801H Recombinant Human PTK6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK6-1798H Recombinant Human PTK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTK6-5932HF Active Recombinant Full Length Human PTK6 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 2-451(end)
Human PTK6-0759H Recombinant Human PTK6 Protein (V2-T451), Tag Free Insect Cell No tag V2-T451
Human PTK6-1798H-B Recombinant Human PTK6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ptk6-8676M Recombinant Mouse Ptk6, His-GST tagged Insect Cell His
Mouse PTK6-001MCL Recombinant Mouse PTK6 cell lysate Insect Cell N/A
Mouse Ptk6-5228M Recombinant Mouse Ptk6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ptk6-528M Active Recombinant Mouse Ptk6 protein, His&GST-tagged Insect Cells His/GST Met1-Val451
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PTK6 involved in several pathways and played different roles in them. We selected most pathways PTK6 participated on our site, such as EGFR1 Signaling Pathway, Focal Adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EGFR1 Signaling PathwayAPPL2;ZNF259;KLF11;GRB7;ARF4;EEF1A1;KRT17;GRB14;ZFP259
Focal AdhesionPAK2B;PDGFA;FLNB;RAP1AB;COL6A3;ITGA2;PDPK1B;PPP1CA;PAK6

PTK6 has several biochemical functions, for example, ATP binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK6 itself. We selected most functions PTK6 had, and list some proteins which have the same functions with PTK6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMVD;RTCD1;G3BP1;HSPA4B;KATNAL1;NLRP3;GSK3AA;SEPHS1;ZAP70
identical protein bindingACTN2;CTSC;DAPK2;CCT7;LZTFL1;SIRT1;ACTG1;NCAM1;VIM
non-membrane spanning protein tyrosine kinase activityABL2;TEC;CSK;DYRK1A;JAK3;JAK1;FES;SYK;EIF2AK2
protein bindingRNF24;KIAA1967;EP300;NEU4;LRIF1;FAM71C;TBX1;PLK1;RAB3IL1
receptor bindingLHB;ALCAM;PVRL2L;HSPA1A;BAAT;SCYL2;GLA;SEMA4D;GNB2L1

PTK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK6.

SFPQ; 80125; WASL; FCHO1; REL; EFHC2

Research Area

Related articles

Ludyga, N; Anastasov, N; et al. Effects of Simultaneous Knockdown of HER2 and PTK6 on Malignancy and Tumor Progression in Human Breast Cancer Cells. MOLECULAR CANCER RESEARCH 11:381-392(2013).
Li, X; Lu, Y; et al. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. ONCOGENE 31:4372-4383(2012).
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