Recombinant Human PTK6 Protein Tyrosine Kinase 6, His-tagged

• Cat.No.: PTK6-1905H
• Product Overview: Recombinant humanfull length PTK6 with His Tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: PTK6, also known as Breasttumor Kinase (BRK), is a Src-like nonreceptor tyrosine kinase, which belongsto Tyr protein kinase family. It is overexpressed in the majority of breastcancer and several other cancer types, while being detected at appreciablelevels in only a limited range of adult tissues that does not include themammary gland. PTK6 contains SH3, SH2, and Kinase domains, with a linkerregion (Linker) between the SH2 and Kinase domains, and the structural basisof the SH3-Linker interaction that results in auto-inhibition of PTK6.
• Form: Liquid in 50 mMTris, pH 7.5 + 200 mM NaCl + 1 mM EDTA + 0.05% Triton X-100 + 5 mM DTT + 50%glycerol.
• Molecular Weight: 55.4 kDa
• Purity: ≥ 95%
• Biological Activity: 166 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 2 ug/ml.
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PTK6
• Full Length: Full L.

Gene Information

• Gene Name: PTK6 PTK6 protein tyrosinekinase 6 [ Homo sapiens ]
• Synonyms: PTK6; PTK6 protein tyrosinekinase 6; BRK; FLJ42088; breast tumor kinase; protein-tyrosine kinase BRK; EC2.7.10.2; Tyrosine-protein kinase 6; OTTHUMP00000031656; Tyrosine-proteinkinase BRK
• Gene ID: 5753
• mRNA Refseq: NM_005975
• Protein Refseq: NP_005966
• MIM: 602004
• UniProt ID: Q13882
• Chromosome Location: 20q13.3
• Pathway: EGFR1 Signaling Pathway; Focal Adhesion
• Function: ATP binding; non-membranespanning protein tyrosine kinase activity; nucleotide binding; proteinbinding; protein serine/threonine kinase activity; transferase activity