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PTPRE

  • Official Full Name

    protein tyrosine phosphatase, receptor type, E

  • Overview

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels.
  • Synonyms

    PTPRE; protein tyrosine phosphatase, receptor type, E; receptor-type tyrosine-protein phosphatase epsilon; PTPE; DKFZp313F1310; FLJ57799; FLJ58245; HPTPE; Protein tyrosine phosphatase epsilon; Protein tyrosine phosphatase receptor type E; Protein tyrosine phosphatase receptor type epsilon; Protein tyrosine phosphatase receptor type epsilon polypeptide; Protein-tyrosine phosphatase epsilon; PTPRE_HUMAN; R PTP Epsilon; R-PTP-epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPRE-1523H Active Recombinant Human PTPRE, GST-tagged Sf9 Insect Cell GST 75 aa-end
Human PTPRE-2061H Recombinant Human PTPRE, His-tagged E.coli His 351-700aa
Human PTPRE-2677HCL Recombinant Human PTPRE 293 Cell Lysate HEK293 N/A
Human PTPRE-2676HCL Recombinant Human PTPRE 293 Cell Lysate HEK293 N/A
Human PTPRE-3685H Recombinant Human PTPRE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPRE-2661H Recombinant Human PTPRE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PTPRE-13695M Recombinant Mouse PTPRE Protein Mammalian Cell His
Mouse Ptpre-5245M Recombinant Mouse Ptpre Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PTPRE-7285M Recombinant Mouse PTPRE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTPRE-7285M-B Recombinant Mouse PTPRE Protein Pre-coupled Magnetic Beads HEK293
Rat PTPRE-4839R Recombinant Rat PTPRE Protein Mammalian Cell His
Rat PTPRE-4498R Recombinant Rat PTPRE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTPRE-4498R-B Recombinant Rat PTPRE Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL35991HF Recombinant Full Length Human Receptor-Type Tyrosine-Protein Phosphatase Epsilon(Ptpre) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-700)
Mus musculus (Mouse) RFL20286MF Recombinant Full Length Mouse Receptor-Type Tyrosine-Protein Phosphatase Epsilon(Ptpre) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-699)
Rattus norvegicus (Rat) RFL26749RF Recombinant Full Length Rat Receptor-Type Tyrosine-Protein Phosphatase Epsilon(Ptpre) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-699)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPRE Related Articles

PTPRE involved in several pathways and played different roles in them. We selected most pathways PTPRE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PTPRE has several biochemical functions, for example, protein binding, protein homodimerization activity, transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRE itself. We selected most functions PTPRE had, and list some proteins which have the same functions with PTPRE. You can find most of the proteins on our site.

Function Related Protein
protein bindingHDHD3;LDHB;CRIPAK;COMP;AURKAIP1;PIK3R3;ZFAND6;NGF;RERG
protein homodimerization activityKIT;DMRTA1;CRYM;VWF;TESC;OLFM4;ACHE;Flt3l;RCHY1
transmembrane receptor protein tyrosine phosphatase activityPTPRD;PTPRB;PTPRR;PTPRO;PTPRM;PTPRC;PTPRE;PTPRN2;PTPRA

PTPRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRE here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRE.

PDGFRB; FYN; Yes1

Mohan, VK; Ganesan, N; et al. Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis. JOURNAL OF GENETICS 93:597-605(2014).
Vlam, L; Cats, EA; et al. Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:175-179(2011).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does PTPRE protein regulate cell signaling pathways? 01/10/2023

PTPRE protein acts as a phosphatase, dephosphorylating specific substrates involved in cell signaling, thereby modulating various cellular processes.

What types of cancer have shown a significant association with PTPRE protein dysregulation? 08/25/2022

Breast cancer, colorectal cancer, and prostate cancer are among the malignancies in which PTPRE protein dysregulation has been implicated.

How does PTPRE protein function in the nervous system? 02/21/2019

PTPRE protein plays a role in synaptic plasticity and neuronal development, and its dysregulation has been implicated in neurodegenerative diseases.

Can PTPRE protein inhibitors have potential side effects in clinical treatment? 11/16/2016

While PTPRE inhibitors may have off-target effects, research is focused on developing selective inhibitors to minimize potential adverse effects.

Are there any clinical trials targeting PTPRE protein in cancer treatment? 09/01/2016

Clinical trials evaluating the efficacy of PTPRE inhibitors in cancer therapy are currently underway, with promising early results.

Customer Reviews (3)

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Reviews
01/26/2021

    Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

    05/21/2020

      the PTPRE protein has demonstrated its efficacy in protein electron microscopy structure analysis.

      03/11/2018

        This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

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