PTPRE
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Official Full Name
protein tyrosine phosphatase, receptor type, E
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Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. -
Synonyms
PTPRE; protein tyrosine phosphatase, receptor type, E; receptor-type tyrosine-protein phosphatase epsilon; PTPE; DKFZp313F1310; FLJ57799; FLJ58245; HPTPE; Protein tyrosine phosphatase epsilon; Protein tyrosine phosphatase receptor type E; Protein tyrosine phosphatase receptor type epsilon; Protein tyrosine phosphatase receptor type epsilon polypeptide; Protein-tyrosine phosphatase epsilon; PTPRE_HUMAN; R PTP Epsilon; R-PTP-epsilon; protein tyrosine phosphatase, receptor type, epsilon polypeptide;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PTPRE Related Articles
PTPRE involved in several pathways and played different roles in them. We selected most pathways PTPRE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PTPRE has several biochemical functions, for example, protein binding, protein homodimerization activity, transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRE itself. We selected most functions PTPRE had, and list some proteins which have the same functions with PTPRE. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | HDHD3;LDHB;CRIPAK;COMP;AURKAIP1;PIK3R3;ZFAND6;NGF;RERG |
protein homodimerization activity | KIT;DMRTA1;CRYM;VWF;TESC;OLFM4;ACHE;Flt3l;RCHY1 |
transmembrane receptor protein tyrosine phosphatase activity | PTPRD;PTPRB;PTPRR;PTPRO;PTPRM;PTPRC;PTPRE;PTPRN2;PTPRA |
PTPRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRE here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRE.
PDGFRB; FYN; Yes1
- Q&As
- Reviews
Q&As (5)
Ask a questionPTPRE protein acts as a phosphatase, dephosphorylating specific substrates involved in cell signaling, thereby modulating various cellular processes.
Breast cancer, colorectal cancer, and prostate cancer are among the malignancies in which PTPRE protein dysregulation has been implicated.
PTPRE protein plays a role in synaptic plasticity and neuronal development, and its dysregulation has been implicated in neurodegenerative diseases.
While PTPRE inhibitors may have off-target effects, research is focused on developing selective inhibitors to minimize potential adverse effects.
Clinical trials evaluating the efficacy of PTPRE inhibitors in cancer therapy are currently underway, with promising early results.
Customer Reviews (3)
Write a reviewWhether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.
the PTPRE protein has demonstrated its efficacy in protein electron microscopy structure analysis.
This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.
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