| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.6 kDa |
| AA Sequence : |
MEPLCPLLLVGFSLPLARALRGNET TADSNETTTTSGPPDPGASQPLLAW LLLPLLLLLLVLLLAAYFFRFRKQR KAVVSTSDKKMPNGILEEQEQQRVM LLSRSPSGPKKYFPIPVEHLEEEIR IRSADDCKQFREEFNSLPSGHIQGT FELANKEENREKNRYPNILPNDHSR VILSQLDGIPCSDYINASYIDGYKE KNKFIAAQGPKQETVNDFWRMVWEQ KSATIVMLTNLKERKEEKCHQYWPD QGCWTYGNIRVCVEDCVVLVDYTIR KFCIQPQLPDGCKAPRLVSQLHFTS WPDFGVPFTPIGMLKFLKKVKTLNP VHAGPIVVHCSAGVGRTGTFIVIDA MMAMMHAEQKVDVFEFVSRIRNQRP QMVQTDMQYTFIYQALLEYYLYGDT ELDVSSLEKHLQTMHGTTTHFDKIG LEEEFRKLTNVRIMKENMRTGNLPA NMKKARVIQIIPYDFNRVILSMKRG QEYTDYINASFIDGYRQKDYFIATQ GPLAHTVEDFWRMIWEWKSHTIVML TEVQEREQDKCYQYWPTEGSVTHGE ITIEIKNDTLSEAISIRDFLVTLNQ PQARQEEQVRVVRQFHFHGWPEIGI PAEGKGMIDLIAAVQKQQQQTGNHP ITVHCSAGAGRTGTFIALSNILERV KAEGLLDVFQAVKSLRLQRPHMVQT LEQYEFCYKVVQDFIDIFSDYANFK TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
