Recombinant Full Length Human RAB7A Protein, C-Flag-tagged

• Cat.No.: RAB7A-435HFL
• Product Overview: Recombinant Full Length Human RAB7A Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 23.3 kDa
• AA Sequence: MTSRKKVLLKVIILGDSGVGKTSLM NQYVNKKFSNQYKATIGADFLTKEV MVDDRLVTMQIWDTAGQERF QSLGVAFYRGADCCVLVFDVTAPNT FKTLDSWRDEFLIQASPRDPENFPF VVLGNKIDLENRQVATKRAQ AWCYSKNNIPYFETSAKEAINVEQA FQTIARNALKQETEVELYNEFPEPI KLDKNDRAKASAESCSC
  TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: RAB7A RAB7A, member RAS oncogene family [ Homo sapiens (human) ]
• Official Symbol: RAB7A
• Synonyms: RAB7; CMT2B; PRO2706
• Gene ID: 7879
• mRNA Refseq: NM_004637.6
• Protein Refseq: NP_004628.4
• MIM: 602298
• UniProt ID: P51149