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RAG2

  • Official Full Name

    recombination activating gene 2

  • Overview

    his gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
  • Synonyms

    RAG2; recombination activating gene 2; V(D)J recombination-activating protein 2; RAG-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAG2-29371TH Recombinant Human RAG2 Wheat Germ N/A 527 amino acids
Human RAG2-2162H Recombinant Human RAG2, GST-tagged E.coli GST C-term-353aa
Human RAG2-2547HCL Recombinant Human RAG2 293 Cell Lysate HEK293 N/A
Human RAG2-425HF Recombinant Full Length Human RAG2 Protein In Vitro Cell Free System 527 amino acids
Mouse RAG2-13890M Recombinant Mouse RAG2 Protein Mammalian Cell His
Mouse RAG2-7401M Recombinant Mouse RAG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RAG2-7401M-B Recombinant Mouse RAG2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RAG2-8961Z Recombinant Zebrafish RAG2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RAG2 Related Articles

RAG2 involved in several pathways and played different roles in them. We selected most pathways RAG2 participated on our site, such as FoxO signaling pathway, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayPRKAA1;NLK;SGK3;GADD45BA;KLF2A;Fasl;GRM1;STK11;INS
Primary iCD4;BTK;IGLL1;RFXAP;RFX5;IL7R;UNG;CD40;DCLRE1C
nodeficiencyCD8B1;CD40LG;RFXANK;IL2RG;CD3E;RFXAP;RAG2;TNFRSF13B;ORAI1

RAG2 has several biochemical functions, for example, DNA binding, chromatin binding, methylated histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG2 itself. We selected most functions RAG2 had, and list some proteins which have the same functions with RAG2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHOXB7A;HOXA13A;DNMT1;H2AFB1;KDM1B;YBX2;NKX2.4A;SOX12;HOXD13
chromatin bindingARNTL1B;KDM1A;FABP1;SSRP1;TLE1;REST;SMARCA2;LDB2A;NCOA5
methylated histone bindingMSH6;CHD8;L3MBTL1;WDR92;ING3;RRP8;MTF2;FAM156A;DPPA3
phosphatidylinositol bindingPXK;SNX31;SNX19A;PASK;SNX6;SH3PXD2AA;PLD1;SH3YL1;WDR35
phosphatidylinositol-3,4,5-trisphosphate bindingAKT1;ANXA8;MAPKAP1;RS1;ZFYVE16;RACGAP1;PHLDA3;BTK;ARHGAP9
phosphatidylinositol-3,4-bisphosphate bindingFAM21C;KIF16B;RAG2;PHLDA3;ADAP2;D6WSU116E;MAPKAP1;NCF1;ZFYVE1
phosphatidylinositol-3,5-bisphosphate bindingWDR45L;RS1;FAM21C;MAPKAP1;SH3PXD2B;COMMD1;RAG2;GBF1;JPH2
phosphatidylinositol-4,5-bisphosphate bindingFAM123A;SESTD1;EXOC1;RS1;ADAP2;SLC9A1;JPH2;KCNJ2;RAB35
ubiquitin protein ligase activityCDC34;TRIM6;NEURL3;HACE1;UBE2T;BFAR;RNF14;UBE2G1;C12orf51
zinc ion bindingDTNBA;COP1;JUB;AGBL3;CXXC1A;DZIP3;PHF23B;ZADH2;CBLL1

RAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG2.

Rosado, MM; Nasta, F; et al. Effects of GSM-Modulated 900 MHz Radiofrequency Electromagnetic Fields on the Hematopoietic Potential of Mouse Bone Marrow Cells. BIOELECTROMAGNETICS 35:559-567(2014).
Brodbeck, T; Nehmann, N; et al. Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model. MOLECULAR CANCER 13:-(2014).
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