RAMP1

  • Official Full Name

    receptor (G protein-coupled) activity modifying protein 1

  • Overview

    The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.

  • Synonyms

    RAMP1;receptor (G protein-coupled) activity modifying protein 1;receptor (calcitonin) activity modifying protein 1 , receptor activity modifying protein 1;receptor activity-modifying protein 1;calcitonin receptor like receptor activity modifying protein 1;CRLR activity modifying protein 1;receptor (G protein coupled) activity modifying protein 1;receptor activity modifying protein 1 [Precursor];CRLR activity-modifying protein 1;receptor activity modifying protein 1;receptor (calcitonin) activity modifying protein 1;calcitonin receptor-like receptor activity modifying protein 1;calcitonin-receptor-like receptor activity-modifying protein 1

Recombinant Proteins

  • Human
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    RAMP1 involved in several pathways and played different roles in them. We selected most pathways RAMP1 participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    GPCR ligand binding NTS,GPR55A,NMBA,XK,ADORA2A,CHRM4,NPFFR2,PROK2,SSTR4,HRH3
    GPCR downstream signaling GCGA,AGT,NPFF,DGKA,OPN1SW1,ARHGEF1A,S1PR1,QRFP,ECT2,EDNRB
    G alpha (s) signalling events ADORA2A,PTHRP2,NPS,ADM2A,RXFP2B,CGA,POMCB,CRH,GPBAR1,PTH2
    Calcitonin-like ligand receptors RAMP2,RAMP3,ADM2A,ADM,ADM2,CALCA,CALCB,CALCRL
    Myometrial Relaxation and Contraction Pathways CNN1,RGS16,RXFP2,IGFBP5,RGS14,ACTA1,GABPB1,ADM,IGFBP4,RGS10
    Class B/2 (Secretin family receptors) EMR3,CALCA,EMR2,RCA2.1,CRHR2,CALCRL,PTHRP2,SETD6,RAMP3,CRHB
    Signal Transduction RGS21,RHOJ,CCK,NMBA,OPN1LW1,GPR55,RBP3,BCL9,SOUL4,MYO7AA
    Endothelin EDNRB,CALCA,EDN1,EDNRA,CNN1,MYL1,ECE1,CALCRL

    Protein Function

    RAMP1 has several biochemical functions, for example, calcitonin receptor activity,calcitonin receptor binding,coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP1 itself. We selected most functions RAMP1 had, and list some proteins which have the same functions with RAMP1. You can find most of the proteins on our site.

    Function Related Protein
    protein transporter activity RAMP2,KPNA5,AP2B1,IPO8,KPNA7,PGAP2,PPIAL4A,RAP1A,ZFYVE16,VPS26B
    calcitonin receptor activity CALCRLA,CALCRL,CALCR
    protein binding CENPW,MAPK8,NUDT18,OPA1,C5orf20,ITGB3B,UBE2H,STK38L,ARHGEF12,STON2
    calcitonin receptor binding CALCA
    coreceptor activity CXCR6,HFE2,PVRL2,LY96,ZP2,RAMP3,TGFBR3,CCR8,ACKR3B,RGMA
    receptor activity MED17,ITGB1B.2,ITGB3A,CD200R3,SLC1A5,NPY2R,CUBN,PVR,TRAM1,TIGIT

    Interacting Protein

    RAMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP1.

    CALCRL

    Resources

    Research Area

    Peptide Hormone G Protein-Coupled Receptors

    References

    • Desai, AJ; Roberts, DJ; et al. Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line. PLOS ONE 9:-(2014).
    • Seiler, K; Nusser, JI; et al. Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment. JOURNAL OF HEADACHE AND PAIN 14:-(2013).

    Reviews

    Write a review

    Q&As

    Ask a question
    Dear You mentionne in this product a FC part, but it is not clear. Does this construction contain a Fc fragment (human or murine ?). 05/27/2024

    Many thanks for your interest in our products. This protein will be produced upon order. You can decide the sequence of this Fc tag.

    Ask a Question for All RAMP1 Products

    Required fields are marked with *

    My Review for All RAMP1 Products

    Required fields are marked with *