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RANBP2

Official Full Name

RAN binding protein 2
Overview

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Synonyms

RANBP2; RAN binding protein 2; ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

GST
His
His (Fc)
Avi
B2M

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RANBP2-2386H	Active Recombinant Human RANBP2 Protein, GST-tagged	E.coli	GST		Inquiry
Human	RANBP2-2250H	Recombinant Human RANBP2 Protein (2601-2802 aa), His-tagged	Yeast	His	2601-2802 aa	Inquiry
Human	RANBP2-3410H	Recombinant Human RANBP2 protein, His-B2M-tagged	E.coli	His-B2M	2601-2802aa	Inquiry
Mouse	RANBP2-13912M	Recombinant Mouse RANBP2 Protein	Mammalian Cell	His		Inquiry
Mouse	RANBP2-7414M	Recombinant Mouse RANBP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RANBP2-7414M-B	Recombinant Mouse RANBP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
RANBP2 Related Articles

RANBP2 involved in several pathways and played different roles in them. We selected most pathways RANBP2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA transport	NUP210;NXF1;THOC1;SUMO3A;TPRB;NUP210L;NUP155;RPP25L;EIF4E2RS1

RANBP2 has several biochemical functions, for example, RNA binding, Ran GTPase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RANBP2 itself. We selected most functions RANBP2 had, and list some proteins which have the same functions with RANBP2. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	IFIT5;YY1;HENMT1;ILF3B;TARDBP;RPL19;ADAD1;RBM20;ZBP1
Ran GTPase binding	RANBP10;IPO13;CSE1L;XPO6;IPO5;IPO4;XPO4;TNPO1;NXT1
ligase activity	TRIM50;TRIML1;RNF169;UCHL1;UBR5;UHRF2;HUWE1;ADSSL;MID1
peptidyl-prolyl cis-trans isomerase activity	PPID;FKBPL;FKBP2;PPWD1;PPIL1;PPIFA;FKBP10;FKBP1B;PPIL6
protein binding	PKHD1L1;ASB7;DDC;E2F6;SEMG2;NUDT12;PAX5;GRIA2;AP1M2
protein complex binding	SIX2;SLC27A5;TUBB;UQCRFS1;LRP2;ERCC8;RXRA;LCK;CPS1
zinc ion binding	ADAM10A;ADAM8A;TRIM109;PRKCB;RUNX1;CPA4;ADH1A;AGBL4;ESR2

RANBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANBP2.

UBE2I; PARK2; RAN; NXF1; ERBB2

Senecal, JL; Isabelle, C; et al. An Autoimmune Myositis-Overlap Syndrome Associated With Autoantibodies to Nuclear Pore Complexes Description and Long-Term Follow-up of the Anti-Nup Syndrome. MEDICINE 93:361-372(2014).

Splinter, D; Tanenbaum, ME; et al. Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry. PLOS BIOLOGY 8:-(2010).