RARG

  • Official Full Name

    retinoic acid receptor, gamma

  • Overview

    This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RARG;retinoic acid receptor, gamma;retinoic acid receptor gamma;NR1B3;RARC;Nuclear receptor subfamily 1 group B member 3;RAR gamma;Retinoic acid receptor gamma 1;Retinoic acid receptor gamma 2;Retinoic acid receptor gamma polypeptide;RAR-gamma;OTTHUMP00000045736;OTTHUMP00000241950;OTTHUMP00000241951;OTTHUMP00000241952;retinoic acid nuclear receptor gamma variant 1;retinoic acid nuclear receptor gamma variant 2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • GST
  • Non
  • His
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    RARG involved in several pathways and played different roles in them. We selected most pathways RARG participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nuclear receptors in lipid metabolism and toxicity ABCC2,CYP24A1,NR1I3,CYP26A1,RARGB,VDRB,NR1I2,CYP27B1,RARGA
    Nuclear Receptor transcription pathway NR2F6A,NR2E3,ESR2A,NR1I2,NR2C2AP,NR5A1A,RORAA,NR2F1A,NR0B2A,RARGA
    Signaling by Retinoic Acid DHRS9,CRABP2A,CRABP2B,RDH7,RDH14,DHRS3,RDH14B,PDK3,CRABP1A,RDH14A
    Generic Transcription Pathway ZNF643,COX18,RARAB,NR0B2A,ZNF426,MED31,NKX2,ZNF286A,ZNF558,ZNF582
    Vitamin A and carotenoid metabolism CRABP1,RDH10,RDH12,BCO2,DHRS3,RBP7,CRABP2
    Nuclear Receptors NR1D2,NR2F1A,NR1I3,NR5A1,RARGB,NR1I2,NR2F2,NR2C2,NR2F6,NR0B1
    Signal Transduction SOX7,CLIP3,ACKR4,PNOCB,EMR2,NOXO1,PYY,FSTL1A,OR10A5,DHRS9
    Gene Expression TRMT5,TRMT44,ZNF614,TRMT61A,SEC61B,CBX3A,POLR3C,CBX3,HNRNPL2,GTF3AB

    Protein Function

    RARG has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARG itself. We selected most functions RARG had, and list some proteins which have the same functions with RARG. You can find most of the proteins on our site.

    Function Related Protein
    steroid hormone receptor activity RORAB,RARA,PAQR7B,RARAA,PAQR7,OR51E2,NR6A1A,RXRAB,PGRMC2,GPR30
    DNA binding ATM,MAFBA,ZSCAN10,ZNF74,ACD,PIAS4,RABGEF1,DLX2B,LEF1,GATA1
    retinoid X receptor binding RARB,NRIP1,NR0B2,MED25,NCOR1,NCOA1,VDR,NR1H4,HMGA1,PPARG
    RNA polymerase II regulatory region sequence-specific DNA binding ATF1,NHLH1,TAL2,MYOD1,BHLHA15,GATA5,ONECUT3,MEF2D,PCGF6,RELB
    zinc ion binding PIAS2,USP16,ADAMTS7,RBM4.1,ADAMTS20,MBTD1,SF3A3,CBLB,ZDHHC15B,NEIL1
    transcription factor activity, sequence-specific DNA binding HOXB3A,ZFP27,KLF2,VDRB,CEBP1,MYF6,PPARAA,MEOX1,ATF5,POU1F1
    protein binding C19orf57,ADAM22,KCND3,UBL7,LY96,NPBWR1,DULLARD,FLI1,ARID5A,MAGEC2
    retinoic acid receptor activity RARGB,RARB,RARAB,NR1D4B,RARA,RARGA,RARAA,ESRRG,RXRA

    Interacting Protein

    RARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARG here. Most of them are supplied by our site. Hope this information will be useful for your research of RARG.

    SORBS3;ZNF423;OIP5;MRPL12;IL24;LSR;RHPN2;ACY3;ZNF576;SPHK1;Sorbs3;MTMR6;FOXC1;myc_human_gene;tff1_human_gene;GREB1;ESR1;RARA

    Resources

    Research Area

    Transcription Regulators in VSMC
    Multiple Sclerosis and Myelin Related Molecules

    References

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