RARG

  • Official Full Name

    retinoic acid receptor, gamma

  • Overview

    This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RARG;retinoic acid receptor, gamma;retinoic acid receptor gamma;NR1B3;RARC;Nuclear receptor subfamily 1 group B member 3;RAR gamma;Retinoic acid receptor gamma 1;Retinoic acid receptor gamma 2;Retinoic acid receptor gamma polypeptide;RAR-gamma;OTTHUMP00000045736;OTTHUMP00000241950;OTTHUMP00000241951;OTTHUMP00000241952;retinoic acid nuclear receptor gamma variant 1;retinoic acid nuclear receptor gamma variant 2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • GST
  • Non
  • His
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    RARG involved in several pathways and played different roles in them. We selected most pathways RARG participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vitamin A and carotenoid metabolism DHRS3,RBP7,CRABP1,BCO2,CRABP2,RDH12,RDH10
    Nuclear Receptors VDRB,NR1I3,NR2F1A,RORAA,NR5A1,RARGB,NR2E1,NR1I2,NR1D2,RARGA
    Gene Expression ZNF114,ZNF624,AGO3B,MAPKAPK2B,ZNF664,DNMT3A,PHF1,ZNF669,MBD3A,POU2F1
    Nuclear receptors in lipid metabolism and toxicity CYP26A1,RARGB,VDRB,NR1I3,RARGA,CYP24A1,CYP27B1,ABCC2,NR1I2
    Signaling by Retinoic Acid CRABP1B,PDK4,CRABP2B,RDH7,RARGA,RDH14B,AKR1C6,RDH14,PDK3B,RDH13
    Signal Transduction RTN4,RGS20,CNR2,TAS2R7,CCBP2,GRK7,QRFPR,OPN4A,CHN1,OPN4B
    Generic Transcription Pathway RORAA,RARAA,ZNF643,ZNF133,ZNF184,ZNF614,ZIK1,ZNF671,ZNF75D,ZNF75A
    Nuclear Receptor transcription pathway NRBP1,NR6A1,NR5A1,NR2F1,NR2E3,NR6A1A,NR0B2A,ESR2A,NR2C2AP,RARGA

    Protein Function

    RARG has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARG itself. We selected most functions RARG had, and list some proteins which have the same functions with RARG. You can find most of the proteins on our site.

    Function Related Protein
    steroid hormone receptor activity NR5A5,RARAA,NR1H3,PAQR7,NR6A1B,ESR2A,OLFR78,RORB,NR5A2,ESRRB
    retinoic acid receptor activity NR1D4B,RARAA,RARGB,RARAB,RARB,ESRRG,RARGA,RARA,RXRA
    RNA polymerase II regulatory region sequence-specific DNA binding FOXC1,HOXD8,RFX6,RORA,ZNF548,LYL1,SP5,AEBP1,KAT2B,HMX3
    retinoid X receptor binding HMGA1,NR0B2,RARB,NR1H4,NCOA1,MED25,NRIP1,NR4A2,VDR,NCOR1
    protein binding HIST2H3C,GLI1,PIAS3,TRIM38,GNA13,GCNT1,HEXIM1,DSP,CLIC2,GAD1
    DNA binding HMBOX1,HIST2H2BE,GTF3A,ESRRGA,ZKSCAN14,IRX5,ZNF512,ONECUT1,HOXB5A,KLF9
    zinc ion binding CPE,XAF1,WHSC1L1,AGBL1,MARCH7,LHX6,PEG10,NR2C2,RNPEP,UQCRC2B
    transcription factor activity, sequence-specific DNA binding LMO4,TADA3,RAB11FIP4A,ZNF550,ETV5,RORCB,NPAS2,TCF4,DMRTA2,ZNF207

    Interacting Protein

    RARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARG here. Most of them are supplied by our site. Hope this information will be useful for your research of RARG.

    SORBS3;ZNF423;OIP5;MRPL12;IL24;LSR;RHPN2;ACY3;ZNF576;SPHK1;Sorbs3;MTMR6;FOXC1;myc_human_gene;tff1_human_gene;GREB1;ESR1;RARA

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