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RASGRP2

  • Official Full Name

    RAS guanyl releasing protein 2 (calcium and DAG-regulated)

  • Overview

    The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    RASGRP2; RAS guanyl releasing protein 2 (calcium and DAG-regulated); RAS guanyl-releasing protein 2; CALDAG GEFI; hCDC25L; cdc25-like protein; F25B3.3 kinase-like protein; guanine exchange factor MCG7; RAS guanyl nucleotide-releasing protein 2; calcium an;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RASGRP2-32H Recombinant Human RASGRP2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RASGRP2-31042TH Recombinant Human RASGRP2, His-tagged E.coli His
Human RASGRP2-34H Recombinant Human RASGRP2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RASGRP2-33H Recombinant Human RASGRP2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RASGRP2-2505HCL Recombinant Human RASGRP2 293 Cell Lysate HEK293 N/A
Human RASGRP2-1861H-B Recombinant Human RASGRP2 Protein Pre-coupled Magnetic Beads HEK293
Human RASGRP2-662HFL Recombinant Full Length Human RASGRP2 Protein, C-Flag-tagged Mammalian cells Flag
Human RASGRP2-4072H Recombinant Human RASGRP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RASGRP2-913H Recombinant Human RASGRP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RASGRP2-1861H Recombinant Human RASGRP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RASGRP2-13954M Recombinant Mouse RASGRP2 Protein Mammalian Cell His
Mouse RASGRP2-7438M-B Recombinant Mouse RASGRP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rasgrp2-5390M Recombinant Mouse Rasgrp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RASGRP2-7438M Recombinant Mouse RASGRP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RASGRP2-3793R Recombinant Rhesus monkey RASGRP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RASGRP2-3610R-B Recombinant Rhesus Macaque RASGRP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RASGRP2-3610R Recombinant Rhesus Macaque RASGRP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RASGRP2 involved in several pathways and played different roles in them. We selected most pathways RASGRP2 participated on our site, such as Adaptive Immune System, Chemokine signaling pathway, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASGRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemKLRB1F;RNF41;CTSE;CD300E;SRMS;NRG4;TREML1;KLRG1;TRAF7
Chemokine signaling pathwayCCL16;SOS1;CCR9;PARD3;IL-8;CXCL2;GNG7;XCL1;CXCL11
Effects of PIP2 hydrolysisTRPC7;TAE1;MGLL;RASGRP2;DGKG;TRPC6A;DGKQ;ABHD6B;DGKA
FCERI mediated NF-kB activationTAB1;RASGRP2
Fc epsilon receptor (FCERI) signalingGRAP2B;LCP2A;GRAP2A;LAT2;TAB1;RASGRP2;ITK
G alpha (q) signalling eventsDGKB;OXTRL;CHRM1;UTS2;TRPC7;MGLL;GPR4;PROK1;RGS18
GPCR downstream signalingTRPC3;RAMP3;ADRA2B;SOUL4;TAE1;DRD3;RGS11;ANXA1;FGD2
Gastrin-CREB signalling pathway via PKC and MAPKANXA1C;TAC2;FPR-RS3;LTB4R;UTS2D;PROKR1A;DGKG;ABHD12;GPR65

RASGRP2 has several biochemical functions, for example, calcium ion binding, diacylglycerol binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RASGRP2 itself. We selected most functions RASGRP2 had, and list some proteins which have the same functions with RASGRP2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingKCNIP3;MMP13;GSNA;GCH1;PCDHB7;FLG2;CABP5A;AASS;PPEF1
diacylglycerol bindingRASGRP3;RASGRP2;UNC13C;TRPC2;UNC13B;RASGRP4;UNC13A;RASGRP1;CDIPT
guanyl-nucleotide exchange factor activityDENND6A;NET1;SH2D3CB;SBF1;ARFGEF1;GCGR;RALGPS2;PRSS56;RAPGEFL1
lipid bindingACOT11A;PACSIN3;S1PR2;FABP1A;APOE;RBP2A;PITPNA;STARD13;FABP7

RASGRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASGRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASGRP2.

q5nf52_fratt; FAM118B; PTCHD2

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