RBPJ

  • Official Full Name

    recombination signal binding protein for immunoglobulin kappa J region

  • Overview

    The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

  • Synonyms

    RBPJ;recombination signal binding protein for immunoglobulin kappa J region;SUH;csl;AOS3;CBF1;KBF2;RBP-J;RBPJK;IGKJRB;RBPSUH;IGKJRB1;recombining binding protein suppressor of hairless;CBF-1;RBP-JK;RBP-J kappa;H-2K binding factor-2;suppressor of hairless homolog;renal carcinoma antigen NY-REN-30;immunoglobulin kappa J region recombination signal binding protein 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cells
  • GST
  • His
  • DDK
  • Myc
  • Non
  • Avi
  • Fc

    Involved Pathway

    RBPJ involved in several pathways and played different roles in them. We selected most pathways RBPJ participated on our site, such as Notch signaling pathway,Epstein-Barr virus infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBPJ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis SRF,HIST1H2BK,TRP53,ATP6V0D2,HIST1H4K,ACTN2,HLA-G,PIK3R5,VDAC3,HDAC1
    Epstein-Barr virus infection TRAF5,SPI1,ENTPD3,HLA-DPA1,TBK1,NFKB2,HSPB1,TRAF3,TNFAIP3,RELB
    Notch signaling pathway PSEN1,LFNG,TLE3A,DTX2,PSEN2,NCOR2,CTBP2,MAML2,DLL4,MFAP2

    Protein Function

    RBPJ has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBPJ itself. We selected most functions RBPJ had, and list some proteins which have the same functions with RBPJ. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NR0B1,OPRK1,UBAP2L,DUSP21,MS4A1,EIF1AD,PSMC3,SH3GLB2,DDL-2,PNPT1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding JUNB,MEF2B,TTC6,NFIC,PITX3,MEF2A,GRHL1,CAMTA1,TFE3A,AKNA
    DNA binding H2AFB3,DRGX,BBX,ASCL1A,HNF4A,EEF1D,MYC,DMTF1,CHTF8,MYCS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF713,NFIC,FIGLA,PGR,FOXA2,KLF5,MAFB,GMEB1,RUNX2,NR2C1
    sequence-specific DNA binding OTX1B,ZFP13,FOXO3A,HOXC12B,GCM2,ZIC3,ZNF232,PAX3A,LMX1BB,NR0B1
    protein N-terminus binding HESX1,RASSF1,PIAS3,RPA3,MYO7A,NCOR2,APTX,EIF3E,TARBP2,EXOC5
    RNA polymerase II core promoter sequence-specific DNA binding SMAD5,FOS,SP1,RUVBL2,NSD1,SUZ12,MTF1,ZNF277,STAT5A,NFIL3
    transcription factor activity, sequence-specific DNA binding ZFY1,PA2G4B,HSFY1,TEAD3B,ZFP287,ZFP28,CITED2,FOXQ1A,ZNF8,ZKSCAN3
    transcription factor binding CEBPB,PYDC3,PBX2,CAMTA2,CTNNB1,NIF3L1,STK4,NAB2,H2-AB1,RBFOX2

    Interacting Protein

    RBPJ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBPJ here. Most of them are supplied by our site. Hope this information will be useful for your research of RBPJ.

    NOTCH1;ATXN1L;ATXN1;RITA1

    RBPJ Related Signal Pathway

    Resources

    Research Area

    Notch Pathway

    References

    • Guiu, J; Bergen, DJM; et al. Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. JOURNAL OF EXPERIMENTAL MEDICINE 211:2411-2423(2014).
    • Querol, L; Clark, PL; et al. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. NEUROLOGY 81:956-963(2013).

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