RBPJ

  • Official Full Name

    recombination signal binding protein for immunoglobulin kappa J region

  • Overview

    The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

  • Synonyms

    RBPJ;recombination signal binding protein for immunoglobulin kappa J region;SUH;csl;AOS3;CBF1;KBF2;RBP-J;RBPJK;IGKJRB;RBPSUH;IGKJRB1;recombining binding protein suppressor of hairless;CBF-1;RBP-JK;RBP-J kappa;H-2K binding factor-2;suppressor of hairless homolog;renal carcinoma antigen NY-REN-30;immunoglobulin kappa J region recombination signal binding protein 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cells
  • GST
  • His
  • DDK
  • Myc
  • Non
  • Avi
  • Fc

    Involved Pathway

    RBPJ involved in several pathways and played different roles in them. We selected most pathways RBPJ participated on our site, such as Notch signaling pathway,Epstein-Barr virus infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBPJ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis HIST1H2BE,PIK3CD,PXN,PIK3CG,HDAC10,REL,ACTN1,GTF2H3,HPN,HIST2H4
    Epstein-Barr virus infection HLA-A,TBP,EIF2AK4,GSK3B,HLA-DQA2,HSPA1L,TBPL1,HLA-DPB1,RB1,PRKACA
    Notch signaling pathway LFNG,MFAP5,NOTCH2,RBPJB,DLB,RBPJA,SNW1,CTBP2A,DLC,YY1

    Protein Function

    RBPJ has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBPJ itself. We selected most functions RBPJ had, and list some proteins which have the same functions with RBPJ. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II repressing transcription factor binding DMAP1,TCF7L2,HDAC1,SIN3A,MTA1,BBS10,BBS5,MTA2,SP1,TBP
    recombinase activity DMC1,XRCC2,RAD51C,RAD51L1,XRCC3,RAD51B,RAD51,RAD51D,RAD51L3
    transcription factor activity, sequence-specific DNA binding AHR,ZFP12,RORAB,IRF4A,ZFY2,ZFP516,FOXG1B,MSC,HEY2,BACH1A
    sequence-specific DNA binding HOXB6B,RREB1,NR2F6,PBX2,POU2F1,MSXE,LHX2A,IRX4A,GATA1A,PBX1B
    chromatin binding ISL1,MBD1,KIAA0101,EP300,NKAP,UPF1,TRP53,RELA,ATF2,NFATC2
    RNA polymerase II core promoter sequence-specific DNA binding SMYD3,TCF7L2,ZNF277,EGR1,SP3,ZFP335,SMAD5,H2AFZ,RUVBL2,WBP2
    protein binding HDHD3,ELMO2,FERD3L,KLHL3,RNF32,SPDYE2,INSIG2,RASSF1,DMKN,FEM1C
    RNA polymerase II core promoter proximal region sequence-specific DNA binding OTX2,PITX3,ZNF217,NKX2-8,HINFP,FOXD1,ZBTB7A,TCF3A,NR3C1,ASCL2
    protein N-terminus binding KCNB1,SDCBP,PIAS3,NPAT,GLRX,PPP1CC,PARP1,STX5A,THAP7,MAU2

    Interacting Protein

    RBPJ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBPJ here. Most of them are supplied by our site. Hope this information will be useful for your research of RBPJ.

    NOTCH1;ATXN1L;ATXN1;RITA1

    RBPJ Related Signal Pathway

    Resources

    Research Area

    Notch Pathway

    References

    • Guiu, J; Bergen, DJM; et al. Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. JOURNAL OF EXPERIMENTAL MEDICINE 211:2411-2423(2014).
    • Querol, L; Clark, PL; et al. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. NEUROLOGY 81:956-963(2013).

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