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REL

Official Full Name

v-rel reticuloendotheliosis viral oncogene homolog
Overview

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Synonyms

REL; C-Rel; proto-oncogene c-Rel; OTTHUMP00000159786; OTTHUMP00000201246; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral; oncogene homolog; NFkB, c-Rel subunit;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	REL-2424HCL	Recombinant Human REL 293 Cell Lysate	HEK293	Non		Inquiry
Human	REL-3421H	Recombinant Human REL protein, His-tagged	E.coli	His	3-616aa	Inquiry
Human	REL-5508H	Recombinant Human REL protein, His-tagged	Yeast	His	3-616aa	Inquiry
Mouse	Rel-2013M	Recombinant Mouse Rel Protein, His-tagged	E.coli	His	Phe93-Gly353	Inquiry
Zebrafish	REL-250Z	Recombinant Zebrafish REL	Mammalian Cell	His		Inquiry
Chicken	REL-4018C	Recombinant Chicken REL	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

REL involved in several pathways and played different roles in them. We selected most pathways REL participated on our site, such as Ras signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with REL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	EFNA4;PIK3R3;FGF19;GNG7;RHOA;ABL2;TEK;SHC1;PLA2G3
Transcriptional misregulation in cancer	DEFA3;MEIS1;MAX;RELA;NGFR;HIST2H3C1;RUNX1T1;RXRB;MLF1
Viral carcinogenesis	MAPK1;HIST1H4A;HPN;HIST1H4I;KAT2B;YWHAB;NRAS;HIST1H2BB;TRADD

REL has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REL itself. We selected most functions REL had, and list some proteins which have the same functions with REL. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II distal enhancer sequence-specific DNA binding	NFKB1;TAL1;H2AFZ;H3F3B;SFPI1;PROP1;PAX4;RELA;NFE2L2
chromatin binding	NFKB2;EYA3;TCF7L1B;TRIM37;ATAD2B;ZGLP1;SAFB;PARP1;CCNT1
protein binding	KRT7;ATP6AP2;SNX6;KDM5B;LIMK1;DDX19A;SYT16;ITPKB;PRKX
transcription factor activity, sequence-specific DNA binding	GCM1;ZFP13;HES1;TAF5L;MEF2D;NFAT5A;PHOX2A;PFDN1;KLF3
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	PROP1;MEOX2;FUBP1;HOXB5;ZEB2;NFE2L1;PBX3;TARDBP;FOXH1

REL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REL here. Most of them are supplied by our site. Hope this information will be useful for your research of REL.

TTC21A; NECAP1; a8k5h9_human; STRA13; b2r8y4_human; 23500

Research Area

Oncoprotein-Transcription Factors

NFkB

Apoptosis Transcription Factors and Regulators

Natural Killer T (NKT) Cells

IL-17 Signaling Related Molecules

C-type Lectin Receptors

NOD-like Receptors and the Inflammasome

RIG-I-like Receptors

Transcription Factors in the Akt Pathway

Nichols, P; Li, L; et al. Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions. MABS 7:212-230(2015).

Heise, N; De Silva, NS; et al. Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappa B transcription factor subunits. JOURNAL OF EXPERIMENTAL MEDICINE 211:2103-2118(2014).