REL
-
Official Full Name
v-rel reticuloendotheliosis viral oncogene homolog
-
Overview
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. -
Synonyms
REL; C-Rel; proto-oncogene c-Rel; OTTHUMP00000159786; OTTHUMP00000201246; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral; oncogene homolog; NFkB, c-Rel subunit;
- Cell & Tissue Lysates
- Recombinant Proteins
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Yeast
- His
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | REL-2424HCL | Recombinant Human REL 293 Cell Lysate | HEK293 | N/A |
|
|
| Human | REL-3421H | Recombinant Human REL protein, His-tagged | E.coli | His | 3-616aa |
|
| Human | REL-5508H | Recombinant Human REL protein, His-tagged | Yeast | His | 3-616aa |
|
| Mouse | Rel-2013M | Recombinant Mouse Rel Protein, His-tagged | E.coli | N-His | Phe93-Gly353 |
|
| Zebrafish | REL-250Z | Recombinant Zebrafish REL | Mammalian Cell | His |
|
|
| Chicken | REL-4018C | Recombinant Chicken REL | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- REL Related Articles
- REL Related Research Area
REL involved in several pathways and played different roles in them. We selected most pathways REL participated on our site, such as Ras signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with REL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | SHC1;IGF1R;GNG12;RAB5C;ANGPT4;HTR7;PAK1;FGF16;RASAL3 |
| Transcriptional misregulation in cancer | RUNX2;PLAT;PDGFA;BCL2A1A;LMO2;MLLT1;TLX1;PAX7;REL |
| Viral carcinogenesis | HIST1H2BH;GTF2E1;YWHAH;EGR3;LTBR;SKP2;GTF2H1;HLA-B;GTF2E2 |
REL has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REL itself. We selected most functions REL had, and list some proteins which have the same functions with REL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II distal enhancer sequence-specific DNA binding | NR1H4;MSC;RELA;TFAP2C;JUN;BACH1A;ESRRB;HNRNPC;CDX2 |
| chromatin binding | KDM8;MEF2A;RNF20;ATRX;RCC1;SKOR2;CBX7;SIRT7;HDAC4 |
| protein binding | KRT79;MAPK10;SMARCAL1;ZFYVE21;SLC22A5;GBF1;FCRL2;ARL6IP4;FBXO28 |
| transcription factor activity, sequence-specific DNA binding | RUNX2;HNF1BA;NKX2-6;HNF1BB;ZFP36L1;MXD1;MEOX1;NANOG;SNAPC5 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | NFKB1;REL;BACH1;MEOX2;NFE2L2;HOXB5;RELA;NFE2L1;ZEB2 |
REL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REL here. Most of them are supplied by our site. Hope this information will be useful for your research of REL.
TTC21A; NECAP1; a8k5h9_human; STRA13; b2r8y4_human; 23500
- Q&As
- Reviews
Ask a Question for All REL Products
Required fields are marked with *
My Review for All REL Products
Required fields are marked with *
