REL

  • Official Full Name

    v-rel reticuloendotheliosis viral oncogene homolog

  • Overview

    NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
  • Synonyms

    REL; C-Rel; proto-oncogene c-Rel; OTTHUMP00000159786; OTTHUMP00000201246; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral; oncogene homolog; NFkB, c-Rel subunit;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Yeast
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human REL-2424HCL Recombinant Human REL 293 Cell Lysate HEK293 N/A
Human REL-3421H Recombinant Human REL protein, His-tagged E.coli His
Human REL-5508H Recombinant Human REL protein, His-tagged Yeast His
Mouse Rel-2013M Recombinant Mouse Rel Protein, His-tagged E.coli N-His
Zebrafish REL-250Z Recombinant Zebrafish REL Mammalian Cell His
Chicken REL-4018C Recombinant Chicken REL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • REL Related Articles
  • REL Related Research Area

REL involved in several pathways and played different roles in them. We selected most pathways REL participated on our site, such as Ras signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with REL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwaySHC1;ABL2;PDGFRB;PAK1;HGF;PDGFD;FGF17;MRAS;KITLG
Transcriptional misregulation in cancerCCNT1;CCND2;KDM6A;SUPT3H;CDK14;DOT1L;TGFBR2;NGFR;ATM
Viral carcinogenesisTRAF2;CCNE2;KAT2A;TRADD;ACTN3;RANBP1;DLG1;DNAJA3;HDAC8

REL has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REL itself. We selected most functions REL had, and list some proteins which have the same functions with REL. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II distal enhancer sequence-specific DNA bindingMEOX2;MED12;NR5A1;SOX10;SFPI1;CREB1;POU4F1;T;GATA2
chromatin bindingTADA2A;FOXO1;PYGO2;KDM6B;DLX2;HMGB4;HMGXB4A;SMAD2;ERCC6
protein bindingCPNE1;TBC1D10A;ZNF365;P2RY1;CREM;GATAD2B;RPL23A;DVL2;PCDHA4
transcription factor activity, sequence-specific DNA bindingHES1;ZNF621;POU2F1B;HOXA6;RBPJB;THRB;HIF1AL;GATA2B;ZFP516
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingZEB2;FUBP1;FOXH1;NFE2L2;HOXB5;BACH1;HCFC1;SIX3;PBX3

REL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REL here. Most of them are supplied by our site. Hope this information will be useful for your research of REL.

TTC21A; NECAP1; a8k5h9_human; STRA13; b2r8y4_human; 23500

Nichols, P; Li, L; et al. Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions. MABS 7:212-230(2015).
Heise, N; De Silva, NS; et al. Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappa B transcription factor subunits. JOURNAL OF EXPERIMENTAL MEDICINE 211:2103-2118(2014).
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