reln Protein, Reelin


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Official Full Name Reelin
Background This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for;cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia,;autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations;of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants;encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their;full length nature has not been determined.
Synonyms RELN; reelin; RL; LIS2; PRO1598; EC 3.4.21.; OT-THUMP00000211831; OTTHUMP00000211830
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • NS0
    • Yeast
    • Tag :
    • His
    • S
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RELN-1504H Recombinant Human RELN Protein (26-254 aa), His-tagged Yeast His
    Human RELN-8060H Recombinant Human RELN protein, His & T7-tagged E.coli His/T7
    Human RELN-8061H Recombinant Human RELN protein, His & T7-tagged E.coli His/T7
    Human RELN-8062H Recombinant Human RELN protein, His & T7-tagged E.coli His/T7
    Mouse Reln-655M Recombinant Mouse Reln Protein, His-tagged NS0 His
    Mouse Reln-8063M Recombinant Mouse Reln protein, His & S-tagged E.coli His/S
    Rat RELN-4993R Recombinant Rat RELN Protein Mammalian Cell His
    Rat Reln-8064R Recombinant Rat Reln protein, His & S-tagged E.coli His/S
    Zebrafish RELN-8094Z Recombinant Zebrafish RELN Mammalian Cell His

    reln involved in several pathways and played different roles in them. We selected most pathways reln participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with reln were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway ITGB4; RPTOR; PIK3R5; EPO; VEGFA; IKBKB; GNB2; HSP90B1; YWHAH; IFNA6
    Focal adhesion XIAP; RAPGEF1; MYLK; SEPP1; PIK3R2; ELK1; ITGB1A; COL2A1B; ITGB3B; GSK3B
    ECM-receptor interaction COL1A1A; COL1A1; THBS2; ITGA7; COL4A4; COL1A2; LAMA4; ITGB4; COL24A1; CD47

    reln has several biochemical functions, for example, hydrolase activity, lipoprotein particle receptor binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by reln itself. We selected most functions reln had, and list some proteins which have the same functions with reln. You can find most of the proteins on our site.

    Function Related Protein
    hydrolase activity CAPN2L; Acr; PSMB9A; BMP1B; PA2G4B; C1RA; OTUB1A; USP9; BMP1A; DHX37
    lipoprotein particle receptor binding Reln; LRP1; APOA5
    metal ion binding ZNF143B; NEK11; HIVEP3; AEBP2; RNF222; KMT2A; TTC4; DNAJA2; MICAL2; NTHL1
    peptidase activity ADAMTS4; PM20D1; DHH; TMPRSS5; FAM105B; CLCA5; CAPN8; TRY; PSMB11; PCSK5
    protein binding TH1L; DOCK10; DNAJC27; FMNL1; PCNP; NKG7; EPS15L1; NAMPT; TNNI2; SGSM3
    serine-type peptidase activity HPN; PRSS40; SEC11A; IRBP; ZFYVE9; PROCA; TRY; TMPRSS11G; GZMM; HTRA1
    very-low-density lipoprotein particle receptor binding Reln; APOE; LRPAP1; APOEB; PCSK9; APOEA

    reln has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with reln here. Most of them are supplied by our site. Hope this information will be useful for your research of reln.

    Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
    Ramirez, AEG; Martinez, AD; et al. Epigenetics and twin studies in psychiatric domains. SALUD MENTAL 31:229-237(2008).

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