REV1
-
Official Full Name
REV1 homolog (S. cerevisiae)
-
Overview
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. -
Synonyms
REV1; REV1 homolog (S. cerevisiae); REV1 (yeast homolog) like , REV1 like (yeast) , REV1L; DNA repair protein REV1; AIBP 80; AIBP80; Alpha integrin binding protein 80; Alpha integrin-binding protein 80; DNA repair protein REV 1; FLJ21523; MGC163283; MGC26225; REV 1 (yeast homolog) like; REV 1; REV 1 homolog; REV 1 like; REV 1 protein; REV 1L; REV1 (yeast homolog) like; REV1 homolog; REV1 like (yeast); REV1 like; Rev1 like terminal deoxycytidyl transferase; REV1 protein; Rev1-like terminal deoxycytidyl transferase; REV1_HUMAN; REV1L; REV1- like; OTTHUMP00000161215; OTTHUMP00000161216;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Yeast
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | REV1-2257H | Recombinant Human REV1, His-tagged | E.coli | His | C-term-351aa | |
| Human | REV1-175H | Recombinant Human REV1, His-tagged | E.coli | His | 51-256aa |
|
| Human | REV1-1531H | Recombinant Human REV1 protein | E.coli | N/A | ||
| Human | REV1-2414HCL | Recombinant Human REV1 293 Cell Lysate | HEK293 | N/A |
|
|
| Human | REV1-5902H | Recombinant Human REV1 Protein (Asn472-Val652), N-His tagged | E.coli | N-His | Asn472-Val652 |
|
| Mouse | REV1-14090M | Recombinant Mouse REV1 Protein | Mammalian Cell | His |
|
|
| Mouse | REV1-7534M | Recombinant Mouse REV1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Mouse | REV1-7534M-B | Recombinant Mouse REV1 Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Yeast | Rev1-1532Y | Recombinant yeast Rev1 protein | E.coli | N/A |
|
|
| Zebrafish | REV1-6683Z | Recombinant Zebrafish REV1 | Mammalian Cell | His |
|
|
| Chicken | REV1-2508C | Recombinant Chicken REV1 | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- REV1 Related Articles
REV1 involved in several pathways and played different roles in them. We selected most pathways REV1 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with REV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi anemia pathway | RMI2;ERCC4;UBE2T;FANCL;PMS2;CDK5R2;SLX4;RAD51C;HER6 |
REV1 has several biochemical functions, for example, damaged DNA binding, deoxycytidyl transferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REV1 itself. We selected most functions REV1 had, and list some proteins which have the same functions with REV1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| damaged DNA binding | TP53BP1;ERCC1;NEIL3;HMGB1;FANCG;TRPC2;MPG;BRCA1;POLK |
| deoxycytidyl transferase activity | |
| metal ion binding | LRP2;CYP2K19;ZNF474;AGBL4;PPP1CA;GPATCH8;PRG4B;DBR1;AMPD3 |
| protein binding | VTI1B;MIA3;RGS2;C1orf38;C17orf81;EIF3J;FOXR2;MTERFD2;AICDA |
REV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of REV1.
REV3L; FHL2; POLH
- Q&As
- Reviews
Q&As (6)
Ask a questionThe REV1 recombinant protein may have a growth-promoting effect in some cases, but may have an inhibitory effect in others. The specific mechanism needs to be further studied.
The expression level of REV1 recombinant protein may be affected by cellular stress, such as DNA damage, but the specific mechanism needs to be further studied.
As a protein related to DNA damage repair, the enzymatic activity of REV1 recombinant protein may provide a potential target for drug development, but a lot of research is still needed to determine its application prospect.
Yes, there may be a correlation between the DNA repair pathway involved in the REV1 recombinant protein and the sensitivity of certain anticancer drugs, which warrants further investigation.
The misintroduction of REV1 recombinant protein during DNA damage repair may lead to genomic variation, but the specific mechanism needs to be further studied.
REV1 recombinant protein has been extensively studied in cell culture (in vitro) and animal models (in vivo).
Customer Reviews (3)
Write a reviewGood solubility and stability in solution.
In special environments, it has good stability.
I have already recommended this brand to my colleagues and friends, and they are all very enthusiastic about this product.
Ask a Question for All REV1 Products
Required fields are marked with *
My Review for All REV1 Products
Required fields are marked with *
