RGN
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Official Full Name
regucalcin (senescence marker protein-30)
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Overview
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5 UTRs, but encoding the same protein. -
Synonyms
RGN; regucalcin (senescence marker protein-30); regucalcin; RC; senescence marker protein 30; SMP30; Gluconolactonase; GNL; RGN_HUMAN; SMP 30; SMP-30; OTTHUMP00000023195; OTTHUMP00000023196; senescence marker protein-30;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Human
- Mammalian Cell
- Yeast
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
RGN involved in several pathways and played different roles in them. We selected most pathways RGN participated on our site, such as Pentose phosphate pathway, Ascorbate and aldarate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose phosphate pathway | PRPS1A;FBP1B;TKT;TKTL2;PFKM;RPIA;PRPS1;PRPS1L1;TKTB |
| Ascorbate and aldarate metabolism | UGT1A2;UGT1A7;RGN;UGT5G1;MIOX;UGT1A3;ALDH9A1A.1;UGT1AB;ALDH2 |
| Metabolic pathways | GBA;GALNT9;CYP4F3;TPH1A;PLA2G12A;CERS5;ACSS1;MTMR14;DPAGT1 |
| Carbon metabolism | ALDH6A1;PFKMB;ALDOAA;SDHDB;ENO2;ADH5;AGXTB;SDHD;MDH2 |
| Degradation of aromatic compounds | AKR1A1B;AKR1A1A;RGN;AKR1A1;ADH5 |
RGN has several biochemical functions, for example, calcium ion binding, enzyme regulator activity, gluconolactonase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGN itself. We selected most functions RGN had, and list some proteins which have the same functions with RGN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CSN2;EFHD2;MAN1A;FREM1A;DCHS1;ASPH;CAPNS1A;PITPNM3;PCDH12 |
| enzyme regulator activity | RGN;APOC3;MTMR9;PSMD3;ATP6V1H;DCP1B;DPM2;CPN2;EIF2B1 |
| gluconolactonase activity | |
| zinc ion binding | PDLIM3B;ENPP2;MEX3C;SNRPC;RNF215;SNAI1A;PHF23;Npepo;XIAP |
RGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGN here. Most of them are supplied by our site. Hope this information will be useful for your research of RGN.
- Q&As
- Reviews
Q&As (7)
Ask a questionRGN plays a key role in tissue repair and regeneration, potentially by promoting cell differentiation and proliferation.
Both exogenous and endogenous factors can regulate RGN's expression and activity, including environmental stress and drug interactions.
RGN expression varies in different cancers, reflecting its complex role in cancer development.
Different levels of RGN expression impact cellular growth regulation, metabolic balance, and differentiation processes.
Minor structural changes can significantly alter RGN's activity, affecting its biological function.
RGN influences various intracellular signaling pathways through interactions with other proteins.
RGN can either promote or inhibit cell proliferation and apoptosis by modulating specific signaling pathways.
Customer Reviews (3)
Write a reviewPrecise results, highly recommended for research.
Efficient service, great for protein analysis.
Accurate data, crucial for our experiments.
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