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RICTOR

Official Full Name

RPTOR independent companion of MTOR, complex 2
Overview

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth;factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).
Synonyms

RICTOR; RPTOR independent companion of MTOR, complex 2; rapamycin-insensitive companion of mTOR; AVO3; KIAA1999; MGC39830; PIA; pianissimo; rapamycin insensitive companion of mTOR; hAVO3; AVO3 homolog; TORC2-specific protein AVO3; mAVO3; DKFZp686B11164;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RICTOR-31328TH	Recombinant Human RICTOR	Wheat Germ	N/A	98 amino acids	Inquiry
Human	RICTOR-1509HCL	Recombinant Human RICTOR cell lysate		N/A		Inquiry
Human	RICTOR-3004H	Recombinant Human RICTOR protein, His-tagged	E.coli	His	1-183 aa	$319 / 25ug
Human	RICTOR-301236H	Recombinant Human RICTOR 9 protein, GST-tagged	E.coli	GST	Met1-Val51	Inquiry
Human	RICTOR-3306H	Recombinant Human RICTOR protein, His-tagged	E.coli	His	1-183 aa	$319 / 25ug
Mouse	RICTOR-14220M	Recombinant Mouse RICTOR Protein	Mammalian Cell	His		Inquiry
Mouse	RICTOR-7602M	Recombinant Mouse RICTOR Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RICTOR-7602M-B	Recombinant Mouse RICTOR Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

RICTOR involved in several pathways and played different roles in them. We selected most pathways RICTOR participated on our site, such as mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RICTOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mTOR signaling pathway	TNF;POLDIP3;STRADA;IGF1;AKT1S1;EIF4E1B;PRKCA;AKT1;RPS6KAL

RICTOR has several biochemical functions, for example, enzyme activator activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RICTOR itself. We selected most functions RICTOR had, and list some proteins which have the same functions with RICTOR. You can find most of the proteins on our site.

Function	Related Protein
enzyme activator activity	CLPSL1;MGST2;MMP17;PITRM1;HSPB2;UBA2;CASP9;GLC8;RICTOR
protein binding	GTF2IRD2;LUZP4;WDTC1;MUSK;NDUFAF4;DARS2;FADD;PDE1B;RPH3A
protein kinase binding	CNPPD1;TCTN2;PFKFB2;CDKN2D;LSM2;FGR;MAPK8IP2;EEF2;STK39
ribosome binding	EIF5A2;ETF1B;SEC61B;EIF6;EIF5A;RICTOR;EIF2S1A;EFTUD1;MTOR

RICTOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RICTOR here. Most of them are supplied by our site. Hope this information will be useful for your research of RICTOR.

MTOR

Limon, JJ; So, L; et al. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E5076-E5085(2014).

Jin, YP; Valenzuela, NM; et al. Everolimus Inhibits Anti-HLA I Antibody-Mediated Endothelial Cell Signaling, Migration and Proliferation More Potently Than Sirolimus. AMERICAN JOURNAL OF TRANSPLANTATION 14:806-819(2014).

mTOR Complexes

PI3K Pathway

Apoptosis Intracellular Kinases