RIPK1
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Official Full Name
receptor (TNFRSF)-interacting serine-threonine kinase 1
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Overview
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene. -
Synonyms
RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Dog
- Human
- Monkey
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Sf9 insect cells
- Wheat Germ
- Yeast
- GST
- His
- Myc
- His|SUMOstar
- SUMO
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- RIPK1 Related Research Area
RIPK1 involved in several pathways and played different roles in them. We selected most pathways RIPK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | BCL2A1;IL-8;MAP3K14;BTK;PIAS4;LY96;CD40;PTGS2;CD40LG |
| Apoptosis | PPP3R2;DSG1;TNFRSF10A;MYD88;CLSPN;PIK3CD;AKT2;BMX;IRF6 |
| Toll-like receptor signaling pathway | CRFB2;MAP2K1;TLR2;IKBKE;IFNA16;IFNAR2;MAP2K4A;TRAF3;CCL5 |
| RIG-I-like receptor signaling pathway | Ifna15;IFNA7;IL8L2;IFNA21;OTUD5A;IL12BA;NT5C3;IFNA16;IFNK |
| Cytosolic DNA-sensing pathway | POLR3H;POLR3D;IFNA12;IL1B;IFNA4;LOC100033925;RIPK3;MB21D1;MAVS |
| TNF signaling pathway | CREB3L2;IL1B;PIK3CA;PIK3R5;MMP9;RPS6KA5;CCL20;CASP10;MAP2K6 |
| Hepatitis C | TRADD;IFNA16;IKBKB;NFKBIA;IFNA7;PPARA;IFNA2;IFNAR2;TNFRSF1A |
| Epstein-Barr virus infection | PRKACA;POLR3K;TP53;CDK1;ENTPD1;NFKBIA;CCNA1;HLA-DPB1;NEDD4 |
RIPK1 has several biochemical functions, for example, ATP binding, death domain binding, death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK1 itself. We selected most functions RIPK1 had, and list some proteins which have the same functions with RIPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAPK12;SRMS;DGKG;PFKM;PIP5K1A;MAPK14;CCT3;DDX49;GTF2F2A |
| death domain binding | DAP;DAPL1;DAP1B;RIPK1;CRADD;TRADD |
| death receptor binding | FADD;NOL3;BID;CFLAR;Fasl;MYD88;PRDM4;CASP8;FEM1B |
| identical protein binding | TRIM39;MDM2;Serpina1c;DYNLT1B;TPD52L1;MYBPC3;PIP4K2C;GYPA;STAT6 |
| protein binding | ANKRD32;CAMSAP1L1;SLC25A6;HIST1H4I;KRT86;BAG2;MAP2K3;PLIN1;CHTOP |
| protein complex binding | CTSL2;TAPBPL;CDK2;GRIN2A;NASP;CAPG;CALY;LRP1;HTR2A |
| protein kinase activity | PTK2AB;TEX14;HIPK2;GM7168;CSNK1G3;BMPR2A;PRKCDA;CAMKK1B;GUCY2E |
| protein serine/threonine kinase activity | SGK1;TLK2;PLK1;PHKG1A;RIOK2;RIOK3;PRKD1;LIMK1;NIM1K |
| ubiquitin protein ligase binding | TRP53;PRKAR2B;UBE2KB;CD40;PML;GABARAPL2;DTX1;MC1R;TPI1 |
RIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK1.
CASP8
- Q&As
- Reviews
Q&As (4)
Ask a questionRIPK1 is one of the most critical intracellular signaling factors mediating necrotic apoptosis.
Necrostatin-1 blocks RIPK1 phosphorylation.
Inhibition of RIPK1 reduces astrocyte proliferation and glial scar formation and promotes recovery of brain function.
RIPK1 is closely related to the study of stroke, neurodegenerative diseases, autoimmune diseases and other diseases.
Customer Reviews (3)
Write a reviewThe proteins accepted were of very high purity and were put into experiments with satisfactory results.
Customer service was patient, prompt and accurate in answering my queries.
Prompt delivery, which helped me to obtain satisfactory experimental results in a short time.
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