RNF135
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Official Full Name
ring finger protein 135 -
Overview
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
RNF135;ring finger protein 135;E3 ubiquitin-protein ligase RNF135;MGC13061;riplet;L13;RIG-I E3 ubiquitin ligase;MMFD;REUL
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- His
- DDK
- Myc
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF135-5071R | Recombinant Rat RNF135 Protein | Mammalian Cells | Rat | His |
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| RNF135-689H | Recombinant Human RNF135 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| RNF135-1519HCL | Recombinant Human RNF135 cell lysate | Human | Non |
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| RNF135-0410H | Recombinant Human RNF135 Protein (A2-V432), Tag Free | E.coli | Human | Non | A2-V432 |
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| RNF135-0411H | Recombinant Human RNF135 Protein (A2-V432), His tagged | E.coli | Human | His | A2-V432 |
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| RNF135-4730R | Recombinant Rat RNF135 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| RNF135-4730R-B | Recombinant Rat RNF135 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RNF135-501H | Recombinant Human RNF135 protein, His-tagged | E.coli | Human | His |
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| Rnf135-5546M | Recombinant Mouse Rnf135 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System,Innate Immune System,NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Negative regulators of RIG-I/MDA5 signaling | CYLD,PCBP2,RNF216,NLRC5,TAX1BP1B,HERC5,TAX1BP1 |
| Innate Immune System | CASP4,DEFB104A,CR1,DEFB4B,ALCAMB,BTR06,BTR22,POLR3F,BTR09,POLR3GLA |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | PCBP2,RNF216,TAX1BP1,TAX1BP1B,TANK,NLRC5,HERC5 |
| Immune System | ICAM4,PLD4,CD300LG,KIF2B,RAPGEF3,SIGLEC7,SEC61B,SUGT1,UBE2F,CHST13 |
Protein Function
RNF135 has several biochemical functions, for example, ligase activity,protein binding,ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | SIAH2L,ARIH1,PIAS3,RNF130,BTR22,TRIM32,MYLIP,SMURF1,RNF182,CMTM2A |
| zinc ion binding | HNF4G,TRIM45,CPB1,WHSC1L1,EHMT1,MARCH3,ZCCHC12,AMFR,BIRC7,MMP1A |
| ubiquitin-protein transferase activity | TSPAN17,RNF187,RFWD3,TRIM21,SHPRH,TRIM5,FBXO22,BIRC5,UBE2E3,UBE2G2 |
| ribonucleoprotein complex binding | SECISBP2,PQBP1,TIMM50,PRMT5,WDR12,SRP54,BOP1,PITX2,PIGC,PRMT7 |
| protein binding | SALL2,C2orf50,DIS3,CXXC5,DRD1,PLCB4,DOCK4,LONP1,MPPE1,SYCE3 |
Interacting Protein
RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.
GOLGA2;CTNNAL1;UBA1;UBE2N;UBE2V1;TACC3
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