RNF135

  • Official Full Name

    ring finger protein 135

  • Overview

    The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

  • Synonyms

    RNF135;ring finger protein 135;E3 ubiquitin-protein ligase RNF135;MGC13061;riplet;L13;RIG-I E3 ubiquitin ligase;MMFD;REUL

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • DDK
  • Myc
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RNF135-5071R Recombinant Rat RNF135 Protein Mammalian Cells Rat His
RNF135-689H Recombinant Human RNF135 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
RNF135-1519HCL Recombinant Human RNF135 cell lysate Human Non
RNF135-0410H Recombinant Human RNF135 Protein (A2-V432), Tag Free E.coli Human Non A2-V432
RNF135-0411H Recombinant Human RNF135 Protein (A2-V432), His tagged E.coli Human His A2-V432
RNF135-4730R Recombinant Rat RNF135 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
RNF135-4730R-B Recombinant Rat RNF135 Protein Pre-coupled Magnetic Beads HEK293 Rat
RNF135-501H Recombinant Human RNF135 protein, His-tagged E.coli Human His 1-210 aa
Rnf135-5546M Recombinant Mouse Rnf135 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    RNF135 involved in several pathways and played different roles in them. We selected most pathways RNF135 participated on our site, such as Immune System,Innate Immune System,NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF135 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Negative regulators of RIG-I/MDA5 signaling RNF216,TAX1BP1,TAX1BP1B,HERC5,PCBP2,CYLD,NLRC5
    Innate Immune System SIRPB1,CLEC6A,BTR29,TANK,DDX41,POLR3GLA,C1rb,CFHL2,PELI3,CYLD
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways HERC5,TAX1BP1B,RNF216,NLRC5,TAX1BP1,PCBP2,TANK
    Immune System IFIT12,CSHL1,ASB7,TRIM63,SIGLEC14,POLR3F,IFIT11,BFB,ARIH1,ACTR2B

    Protein Function

    RNF135 has several biochemical functions, for example, ligase activity,protein binding,ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF135 itself. We selected most functions RNF135 had, and list some proteins which have the same functions with RNF135. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity GLULA,MARCH11,RNF34,LNX1,RNF126,MKRN1,CBX4,LIPT2,TRIM41,RBBP6
    zinc ion binding CHMP1A,NR4A3,ING3,CNOT4B,ZNF8,ASH1L,MMP23B,RNF25,ZMIZ1A,CA7
    ribonucleoprotein complex binding PES1,PRPF31,PRMT5,PRPF6,PQBP1,RNASEL,IFIH1,UHMK1,SECISBP2,CD2BP2
    ubiquitin-protein transferase activity PEX2,TRIM69,MIB1,SIAH1,RNF31,TRAF5,BIRC2,PJA2,RNF4,ANKIB1A
    protein binding YY1A,MAGEB4,LMO3,HIST3H3,RQCD1,COL6A2,CTNNBIP1,H3F3C,PRRC1,DIS3L

    Interacting Protein

    RNF135 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF135 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF135.

    GOLGA2;CTNNAL1;UBA1;UBE2N;UBE2V1;TACC3

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