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RNF14

  • Official Full Name

    ring finger protein 14

  • Overview

    The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
  • Synonyms

    RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; Androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA 54; E3 ubiquitin protein ligase RNF14; FLJ26004; HFB 30; HRIHFB2038; RNF 14; RNF14_HUMAN; TRIAD 2; Triad2 protein; OTTHUMP00000160065; OTTHUMP00000160066;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RNF14-686H Recombinant Human RNF14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RNF14-2296HCL Recombinant Human RNF14 293 Cell Lysate HEK293 N/A
Human RNF14-5464H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RNF14-1911H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RNF14-0685H Recombinant Human RNF14 Protein (S2-D474), Tag Free E.coli No tag S2-D474
Human RNF14-4908H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RNF14-0686H Recombinant Human RNF14 Protein (S2-D474), His tagged E.coli His S2-D474
Human RNF14-2948H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse RNF14-14303M Recombinant Mouse RNF14 Protein Mammalian Cell His
Mouse RNF14-7653M Recombinant Mouse RNF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RNF14-7653M-B Recombinant Mouse RNF14 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rnf14-5547M Recombinant Mouse Rnf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque RNF14-3930R Recombinant Rhesus monkey RNF14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RNF14-3747R-B Recombinant Rhesus Macaque RNF14 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RNF14-3747R Recombinant Rhesus Macaque RNF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RNF14-319Z Recombinant Zebrafish RNF14 Mammalian Cell His
Chicken RNF14-2332C Recombinant Chicken RNF14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RNF14 involved in several pathways and played different roles in them. We selected most pathways RNF14 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemEVL;KIF22;ASB2;RNF182;LAIR1;KIF18A;ASB8;FGF20A;GRAP2B
Androgen receptor signaling pathwayCTNNB1;CCDC102A;SVILA;HMGB2A;NCOA2;RNF4;POU2F1B;RUNX2A;CREBBP
Antigen processing: Ubiquitination &ampASB2;RNF4;TRIM39;ASB10;FBXO44;UBE2V1;TPP2;CMTM2A;ASB8
Proteasome degradationSPSB2;IWS1;LTN1;TRIM11;SPSB1;UBE2V2;RNF41;RNF14;ASB14
Class I MHC mediated antigen processing &ampUBE2L6;RNF138;RBCK1;ERAP2;SPSB1;ERAP1;RNF144B;DZIP3;CYBA
presentationTRIM69;UBR1;ASB14;KLHL20;KLHL21;CD207;RNF41;RNF220;PJA1
Immune SystemCTS7;IRF6;ASB8;TREX1;BTR16;TAX1BP1B;ACTR1B;HECTD3;KIF20A

RNF14 has several biochemical functions, for example, androgen receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF14 itself. We selected most functions RNF14 had, and list some proteins which have the same functions with RNF14. You can find most of the proteins on our site.

Function Related Protein
androgen receptor bindingFOXP1;GRIP1;TCF21;FHL2;PRKCB;NCOA4;RNF6;NCOA1;WIPI1
ligase activityCOP1;GLULA;RNF19A;UBE2IB;BTRC;CTPS1A;RNF146;CBLC;RCHY1
protein bindingEPN3;NTSR1;RCN3;NR5A2;LRGUK;ALOX5;KCNMB4;SMARCD3;NSMCE4A
transcription coactivator activityESRRB;GTF2F1;MED12;TFDP1;JMY;MKL1;MED17;ATF6;JUNBB
ubiquitin conjugating enzyme bindingRNF19B;FOXL2;ZMYM2;TOLLIP;DCUN1D2B;PARK2;ARIH2;RNF217;RNF14
ubiquitin protein ligase activityCDC34B;UBE2J2;SIAH1;SMURF2;RNF175;UBE2Z;MED31;PDZRN4;UBE2G1
ubiquitin-like protein transferase activityARIH1;RNF14;UBL4A;ATG16L1;ATG3;RNF139
zinc ion bindingRP9;TRIM63;LIMK1;TRIM35-21;RNF168;APOBEC2A;NR5A2;LHX6;RNF141

RNF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF14.

UBE2D1; UBE2D4; DACH1; AR; HNF1A; UBE2E1; UBE2D3; UBE2D2; UBE2V1; FAM46A

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