RNF14

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RNF14

Official Full Name ring finger protein 14
Background The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Synonyms RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; Androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA 54; E3 ubiquitin protein ligase RNF14; FLJ26004; HFB 30; HRIHFB2038; RNF 14; RNF14_HUMAN; TRIAD 2; Triad2 protein; OTTHUMP00000160065; OTTHUMP00000160066
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF14-1911H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RNF14-2296HCL Recombinant Human RNF14 293 Cell Lysate HEK293 N/A
    Human RNF14-2948H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RNF14-4908H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RNF14-5464H Recombinant Human RNF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RNF14-686H Recombinant Human RNF14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse RNF14-14303M Recombinant Mouse RNF14 Protein Mammalian Cell His
    Mouse Rnf14-5547M Recombinant Mouse Rnf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque RNF14-3930R Recombinant Rhesus monkey RNF14 Protein, His-tagged Mammalian Cell His
    Chicken RNF14-2332C Recombinant Chicken RNF14 Mammalian Cell His
    Zebrafish RNF14-319Z Recombinant Zebrafish RNF14 Mammalian Cell His

    RNF14 involved in several pathways and played different roles in them. We selected most pathways RNF14 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System LILRB2; NCR3LG1; FBXO3; IGLC2; KIFAP3; SPSB2; SH3RF1; SEC24A; RNF19B; TRIM50
    Androgen receptor signaling pathway KAT7B; CTNNB2; SMARCE1; RUNX2A; NCOA2; RNF4; RANBP9; SMAD3B; CARM1; NR0B2A
    Antigen processing: Ubiquitination &amp UBE2L6; KLHL20; ASB18; ASB2; PJA2; RNF144B; HUWE1; KLHL21; UBE2V1; RNF6
    Proteasome degradation UBE2V1; VPRBP; RNF14; WWP1; ASB2; FBXO44; UBE2F; SPSB1; ASB13; ASB3
    Class I MHC mediated antigen processing &amp KLHL21; UFL1; UBE2U; CYBB; GAN; BLMH; UBE2F; LRR1; PJA1; VPRBP
    presentation CYBB; UFL1; PJA1; UBE2V1; TRIM50; ERAP1; ASB13; RNF19B; RNF41; ASB18
    Immune System IFI16; FBXO44; ASB8; RAP1GAP2B; SEC61B; IFIT2; MB21D1; PANX1B; RNF25; CD300LG

    RNF14 has several biochemical functions, for example, androgen receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF14 itself. We selected most functions RNF14 had, and list some proteins which have the same functions with RNF14. You can find most of the proteins on our site.

    Function Related Protein
    androgen receptor binding KAT5; RB1; NRIP1; NCOA4; CTNNB1; CCNE1; PRKCBB; KDM4C; WIPI1; FOXP1
    ligase activity AMFR; RFFL; SH3RF1; TRIM62; GLULB; NAPRT; CNOT4; TRIM50; BARD1; FANCL
    protein binding CGGBP1; TBATA; KRIT1; TRPC5; SLC22A17; NOA1; BCL2L12; EFNA3; CARHSP1; CLOCKB
    transcription coactivator activity SETD3; KAT5; PPARGC1A; ECD; SMARCA4; NFKB2; VGLL2; RIPK3; PRDM16; CBFB
    ubiquitin conjugating enzyme binding DCUN1D1; RNF144AB; ARIH1L; RNF217; TRAF6; RASD2; DCUN1D2A; TCHP; DCUN1D4; RNF19A
    ubiquitin protein ligase activity SIAH1A; MGRN1; HECW1; TRIP12; MSL2B; HECTD3; RNF25; RBBP6; TOPORS; MED7
    ubiquitin-like protein transferase activity ARIH1; RNF14; ATG3; RNF139; UBL4A; ATG16L1
    zinc ion binding BRPF1; GATA3; CDADC1; BIRC3; RBM10; FTR50; SF1; MIB1; CA12; ADAM1B

    RNF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF14.

    UBE2D1; UBE2D4; DACH1; AR; HNF1A; UBE2E1; UBE2D3; UBE2D2; UBE2V1; FAM46A

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