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Official Full Name ring finger protein 216
Background This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
Synonyms RNF216; ring finger protein 216; E3 ubiquitin-protein ligase RNF216; TRIAD3; U7I1; UBCE7IP1; ZIN; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF216-3625H Recombinant Human RNF216 protein, GST-tagged E.coli GST
    Human RNF216-2282HCL Recombinant Human RNF216 293 Cell Lysate HEK293 N/A
    Mouse RNF216-14335M Recombinant Mouse RNF216 Protein Mammalian Cell His

    Rnf216 involved in several pathways and played different roles in them. We selected most pathways Rnf216 participated on our site, such as Gastric cancer network 1, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rnf216 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gastric cancer network 1 ESM1; GATS; TOP2A; S100P; SMOC2; RNF216; C21orf33; ECT2; TPX2; ACTL6A
    Innate Immune System NLRP4; ALCAMB; CRP; CFHL3; POLR3G; PLD4; PELI2; TNRC5; TREX1; DEFB106A
    Negative regulators of RIG-I/MDA5 signaling CYLD; PCBP2; HERC5; RNF216; TAX1BP1; RNF135; NLRC5; TAX1BP1B
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways HERC5; NLRC5; PCBP2; TAX1BP1B; RNF216; RNF135; TANK; TAX1BP1
    TNF-alpha/NF-kB Signaling Pathway TRPC4AP; MARK2; LRPPRC; TNIP1; KIAA1967; NR2C2; RNF25; PFDN2; USP2; PAPOLA
    protein ubiquitylation UBE2E3; UEVLD; UBA5; UBE2U; RNF216

    Rnf216 has several biochemical functions, for example, ligase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rnf216 itself. We selected most functions Rnf216 had, and list some proteins which have the same functions with Rnf216. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity PPIL2; TTLL4; TRIM71; KCMF1; HERC6; SMURF1; DTX4; RING1; TRIM23; TRAF6
    metal ion binding PDCD2; ZFP423; KDM5D; TNFSF10; ASAP3; TRIM43C; RNF128A; CAR15; LOXL2B; ZNF574
    protein binding TBL1XR1; TPM3; Mill2; DERL3; MGST3; AKR7A3; CSDC2; NSUN4; FCRL4; HBB

    Rnf216 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rnf216 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rnf216.

    dinB; RNF11

    Zhang, TT; Prives, C; et al. Cyclin A-CDK phosphorylation regulates MDM2 protein interactions. JOURNAL OF BIOLOGICAL CHEMISTRY 276:29702-29710(2001).

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