RNF43

  • Official Full Name

    ring finger protein 43
  • Synonyms

    RNF43;ring finger protein 43;18505;ENSG00000108375;URCC;RNF124;17q22;FLJ20315, FLJ77466, FLJ99338, MGC125630, DKFZp781H0392, DKFZp781H02126;E3 ubiquitin-protein ligase RNF43;E3 ubiquitin-protein ligase RNF43

Recombinant Proteins

  • Human
  • E.coli
  • HEK293
  • Mammalian Cells
  • His
  • Fc
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RNF43-2858H Recombinant Human RNF43 protein, His-tagged E.coli Human His
RNF43-767H Active Recombinant Human RNF43 protein, hFc-tagged HEK293 Human Fc Met1-Tyr197
RNF43-1145H Recombinant Human RNF43 Mammalian Cells Human His
RNF43-768H Recombinant Human RNF43 Protein, His-tagged HEK293 Human His Met1-Tyr197
RNF43-0655H Active Recombinant Human RNF43 protein, Fc-tagged HEK293 Human Fc 44-197 a.a.
RNF43-3995H Recombinant Human RNF43 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
RNF43-3995H-B Recombinant Human RNF43 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    RNF43 involved in several pathways and played different roles in them. We selected most pathways RNF43 participated on our site, such as Disease,Diseases of signal transduction,RNF mutants show enhanced WNT signaling and proliferation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Wnt SOX4A,RSPO4,SOX32,BCL9L,BCL9,AES,KREMEN1,KREMEN2,LGR5,ASH2L
    TCF dependent signaling in response to WNT SOX32,RBBP5,SOX7,RSPO3,SOX6,RNF146,HECW1,TNKS,RSPO1,USP34
    Signaling by WNT in cancer KREMEN2,KREMEN1,TNKS2,TNKS
    Disease PSIP1,TTR,ARF1,CCDC59,CDK9,NUP35,SFTPC,KREMEN1,KREMEN2,STRA6
    Diseases of signal transduction HEY1,HDAC5,OPN1MW,TTR,RLBP1,CDK8,MYO18A,HEYL,FKBP1A,OS9
    Signal Transduction PAG1,FSTL1A,PROKR1,PRC1,ARHGEF18A,WDR19,KEL,BCO2L,CXCR7B,TAX1BP1B
    Regulation of FZD by ubiquitination LGR6,RSPO4,LGR4,RSPO1,LGR5,ZNRF3,RSPO3,FMNL3,RSPO2

    Protein Function

    RNF43 has several biochemical functions, for example, frizzled binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF43 itself. We selected most functions RNF43 had, and list some proteins which have the same functions with RNF43. You can find most of the proteins on our site.

    Function Related Protein
    frizzled binding SDCBP,WNT7B,WNT10B,CTHRC1,WNT2BB,WNT7A,FZD7,WNT3,WNT16,WNT2B
    protein binding COG5,FBXO9,ANO2,ELK1,EFEMP1,SCO1,PRKG1,GRM1,ZNF202,FARSA
    ligase activity RNF181,GLULC,TRIM56,TTLL4,PIAS1,UBE4B,TRIM6,UBE2NA,PARK2,TRIML1
    zinc ion binding PRKCB,TRIM52,OTUD7B,USP51,MTA2,TRIM30A,ZDHHC5A,HLTF,ADH4,PJA2
    ubiquitin-protein transferase activity SMURF2,UHRF2,BARD1,BRCA1,UBE3C,SIAH1,FBXL3,ARIH1,MUL1A,TRIM56

    Interacting Protein

    RNF43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF43 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF43.

    UBE2D3;UBE2D2;SFPQ;NONO;AKAP8L;UBA1;UBB;UBE2D1;UBE2E1

    Resources

    Research Area

    References

    • Sakamoto, H; Kuboki, Y; et al. Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas. MODERN PATHOLOGY 28:261-267(2015).
    • Xi, SY; Zhang, XK; et al. Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:490-496(2015).

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