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RNF43

  • Official Full Name

    ring finger protein 43

  • Synonyms

    RNF43;ring finger protein 43;18505;ENSG00000108375;URCC;RNF124;17q22;FLJ20315, FLJ77466, FLJ99338, MGC125630, DKFZp781H0392, DKFZp781H02126;E3 ubiquitin-protein ligase RNF43;E3 ubiquitin-protein ligase RNF43;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • Mammalian Cell
  • Fc
  • hFc
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RNF43-767H Active Recombinant Human RNF43 protein, hFc-tagged HEK293 hFc Met1-Tyr197
Human RNF43-1145H Recombinant Human RNF43 Mammalian Cell His
Human RNF43-768H Recombinant Human RNF43 Protein, His-tagged HEK293 His Met1-Tyr197
Human RNF43-3995H Recombinant Human RNF43 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RNF43-3995H-B Recombinant Human RNF43 Protein Pre-coupled Magnetic Beads HEK293
Human RNF43-2858H Recombinant Human RNF43 protein, His-tagged E.coli His
Human RNF43-0655H Active Recombinant Human RNF43 protein, Fc-tagged HEK293 Fc Gln44-Tyr197
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RNF43 Related Articles
  • RNF43 Related Research Area

RNF43 involved in several pathways and played different roles in them. We selected most pathways RNF43 participated on our site, such as Disease, Diseases of signal transduction, RNF mutants show enhanced WNT signaling and proliferation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DiseaseTCEB3;FDX1;NPM1;HDAC6;FDX1L;APOBEC3G;TAF1L;AP2A1;OPN1LW
Diseases of signal transductionCCNC;LRRFIP1;FGFR1OP;RBP1;CTBP2;OPN1LW;MYO18A;STRA6;KREMEN1
RNF mutants show enhanced WNT signaling and proliferation
Regulation of FZD by ubiquitinationRNF43;FMNL3;LGR4;RSPO1;LGR6;RSPO3;LGR5;RSPO2;RSPO4
Signal TransductionLGR4;CALCB;S1PR3;ARHGAP28;RNF41;SDR9C7;PTHLHA;ARHGAP9;EDNRAB
Signaling by WNT in cancerTNKS;KREMEN1;TNKS2;RNF43;KREMEN2
Signaling by WntKREMEN2;PRICKLE1;RSPO2;GPR177;RBBP5;BCL9;SOX7;DACT1;SOX9B
TCF dependent signaling in response to WNTSOX32;CDC73;RSPO4;HECW1B;PYGO2;WNT8-2;RNF146;DACT1;RSPO1

RNF43 has several biochemical functions, for example, frizzled binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF43 itself. We selected most functions RNF43 had, and list some proteins which have the same functions with RNF43. You can find most of the proteins on our site.

Function Related Protein
frizzled bindingRSPO3;DVL3A;DVL3;ZNRF3;WNT1;FZD1;WNT7AA;WNT2;WNT9B
ligase activityUBR1;PELI1;RNF135;UBE2I;RC3H2;LIPT2;RNF144AA;RNF217;TTC3
protein bindingFBXW8;EIF4EBP2;MDFI;ARF1;RPS15;MSH2;PCDHA4;GPSM1;HFE2
ubiquitin-protein transferase activityWWP2;CNOT4B;HECTD3;FBXL14B;TRIM24;FANCL;UBE2T;MARCH5;RNF5
zinc ion bindingZCCHC11;NEURL1B;RNF39;VAT1L;ZSWIM3;GALT;C6AST3;LONRF1L;NEIL1

RNF43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF43 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF43.

UBE2D3; UBE2D2; SFPQ; NONO; AKAP8L; UBA1; UBB; UBE2D1; UBE2E1

Sakamoto, H; Kuboki, Y; et al. Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas. MODERN PATHOLOGY 28:261-267(2015).
Xi, SY; Zhang, XK; et al. Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:490-496(2015).
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