RNF43
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Official Full Name
ring finger protein 43 -
Synonyms
RNF43;ring finger protein 43;18505;ENSG00000108375;URCC;RNF124;17q22;FLJ20315, FLJ77466, FLJ99338, MGC125630, DKFZp781H0392, DKFZp781H02126;E3 ubiquitin-protein ligase RNF43;E3 ubiquitin-protein ligase RNF43
Recombinant Proteins
- Human
- E.coli
- HEK293
- Mammalian Cells
- His
- Fc
- Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF43-2858H | Recombinant Human RNF43 protein, His-tagged | E.coli | Human | His | ||
| RNF43-767H |
Active Recombinant Human RNF43 protein, hFc-tagged
|
HEK293 | Human | Fc | Met1-Tyr197 |
|
| RNF43-1145H | Recombinant Human RNF43 | Mammalian Cells | Human | His |
|
|
| RNF43-768H | Recombinant Human RNF43 Protein, His-tagged | HEK293 | Human | His | Met1-Tyr197 |
|
| RNF43-0655H | Active Recombinant Human RNF43 protein, Fc-tagged | HEK293 | Human | Fc | 44-197 a.a. |
|
| RNF43-3995H | Recombinant Human RNF43 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
|
| RNF43-3995H-B | Recombinant Human RNF43 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
Involved Pathway
RNF43 involved in several pathways and played different roles in them. We selected most pathways RNF43 participated on our site, such as Disease,Diseases of signal transduction,RNF mutants show enhanced WNT signaling and proliferation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of FZD by ubiquitination | LGR6,FMNL3,LGR4,RSPO4,RSPO2,RSPO1,LGR5,RSPO3,ZNRF3 |
| Diseases of signal transduction | FGFR1OP,HEY1,CPSF6,MIB1,JAG2,CTBP2,TRAT1,CDC37,CDK8,DERL2 |
| Signal Transduction | FAM105B,RIT1,WDR19,ACKR4,SH2B3,RHOT1,PMCH,TLE2,OPN1LW1,PYYA |
| TCF dependent signaling in response to WNT | USP34,BCL9,CDC73,PYGO2,C,SRY,SOX9B,RSPO1,BCL9L,RSPO4 |
| Disease | AMN,EPM2A,CHMP4C,AP2A2,AP1B1,WHSC2,RLBP1,TNKS2,CTBP1,AP1G1 |
| Signaling by Wnt | TMED5,RSPO4,WLS,SOX9A,USP34,BCL9L,KREMEN1,LGR4,RYK,SOX9B |
| Signaling by WNT in cancer | KREMEN1,TNKS,KREMEN2,TNKS2 |
Protein Function
RNF43 has several biochemical functions, for example, frizzled binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF43 itself. We selected most functions RNF43 had, and list some proteins which have the same functions with RNF43. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HSPA9,APOOL,SCARA5,NR1D2,SPZ1,CNST,DERL1,CDX1,Ctsl,SULT1B1 |
| frizzled binding | WNT4A,WNT9B,WNT6,WNT3,SDCBP,FZD7,WNT2,WNT5A,MYOC,WNT8B |
| zinc ion binding | MAP3K7IP3,CBLC,CA5B,ZDHHC22,ZNF34,ZNRF2B,PCGF3,MATR3,ZFR,FNTB |
| ligase activity | TRIM4,RNF169,MARCH1,TRIM21,EGR2,MKRN3,TRIM24,RNF217,MARCH11,SIAH1A |
| ubiquitin-protein transferase activity | TRAF3,UBE2L6,LNX1,FBXO11,MUL1B,RNF181,TRIM17,FBXO9,ARIH1,FBXO40.1 |
Interacting Protein
RNF43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF43 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF43.
UBE2D3;UBE2D2;SFPQ;NONO;AKAP8L;UBA1;UBB;UBE2D1;UBE2E1
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References
- Sakamoto, H; Kuboki, Y; et al. Clinicopathological significance of somatic RNF43 mutation and aberrant expression of ring finger protein 43 in intraductal papillary mucinous neoplasms of the pancreas. MODERN PATHOLOGY 28:261-267(2015).
- Xi, SY; Zhang, XK; et al. Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:490-496(2015).
