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RNPS1

  • Official Full Name

    RNA binding protein S1, serine-rich domain

  • Overview

    This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
  • Synonyms

    RNPS1; RNA binding protein S1, serine-rich domain; E5.1; RNA-binding protein with serine-rich domain 1; SR protein; SR-related protein LDC2; RNA-binding protein S1, serine-rich domain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RNPS1-179H Recombinant Human RNPS1 protein, T7-tagged E.coli T7
Human RNPS1-2354H Recombinant Human RNPS1, GST-tagged E.coli GST 1-305aa
Human RNPS1-2258HCL Recombinant Human RNPS1 293 Cell Lysate HEK293 N/A
Human RNPS1-2259HCL Recombinant Human RNPS1 293 Cell Lysate HEK293 N/A
Human RNPS1-1105H Recombinant Human RNPS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse RNPS1-14365M Recombinant Mouse RNPS1 Protein Mammalian Cell His
Mouse Rnps1-5564M Recombinant Mouse Rnps1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RNPS1-7699M Recombinant Mouse RNPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RNPS1-7699M-B Recombinant Mouse RNPS1 Protein Pre-coupled Magnetic Beads HEK293
Rat RNPS1-5091R Recombinant Rat RNPS1 Protein Mammalian Cell His
Rat RNPS1-4750R-B Recombinant Rat RNPS1 Protein Pre-coupled Magnetic Beads HEK293
Rat RNPS1-4750R Recombinant Rat RNPS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RNPS1-10150Z Recombinant Zebrafish RNPS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RNPS1 involved in several pathways and played different roles in them. We selected most pathways RNPS1 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), which may be useful for your reference. Also, other proteins which involved in the same pathway with RNPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cleavage of Growing Transcript in the Termination RegionLSM10;U2AF2;CLP1;PAPOLA;ZNF473;CSTF2;CSTF1;NUDT21;THOC4
Gene ExpressionESRRA;COBRA1;SAP130;ZNF649;ELAC2;PRDX2;ZNF253;APEH;ZFP1
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)SMG9;RNPS1;SMG8
Nonsense-Mediated Decay (NMD)SMG9;RNPS1;SMG8
Processing of Capped Intron-Containing Pre-mRNAPRPF8;PCBP2;HNRNPH1;THOC4;YBX1;PAPOLA;METTL14;HNRNPD;HNRNPL2
RNA Polymerase II TranscriptionCSTF1;CSTF3;SRSF11;PAPOLA;U2AF2;CSTF2;LSM11;RNPS1;THOC4
RNA Polymerase II Transcription TerminationSRSF11;PAPOLA;NUDT21;CSTF1;ZNF473;THOC4;RNPS1;CLP1;LSM11
RNA transportNXT1;PAIP1;EIF1;PRMT5;EIF4EA;WIBG;PNN;RPP40;PABPC1L

RNPS1 has several biochemical functions, for example, NOT RNA binding, mRNA 3-UTR binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNPS1 itself. We selected most functions RNPS1 had, and list some proteins which have the same functions with RNPS1. You can find most of the proteins on our site.

Function Related Protein
NOT RNA bindingNCBP2;RNPS1
mRNA 3-UTR bindingIGF2BP1;CPEB1B;ELAVL2;CPEB3;CSDA;ELAVL4;YBX2;CPEB1;PARN
nucleotide bindingMYHZ1.1;UBE2IB;VSIG8B;NT5C1AA;CDK12;TTLL11;TTLL5;MKNK2B;TDRD9
poly(A) RNA bindingNCOA5;ZFR;RPS10;HSPA9;SMC1A;SNRPB;DROSHA;HMGB3;HIST1H4I
protein bindingSNX10;NDUFA4;NPHP3;ZKSCAN5;GGACT;WDR61;RMND1;ARMC7;KMT2E

RNPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNPS1.

SRPK1; UPF3B; SART3; YWHAG; THRAP3; SRPK2; U2AF1; SRSF1

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