Rtn4

  • Official Full Name

    reticulon 4

  • Overview

    This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    RTN4; reticulon 4; ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545; reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RTN4-3990H Recombinant Human RTN4, GST tagged E.coli GST
Human RTN4-2121HCL Recombinant Human RTN4 293 Cell Lysate HEK293 N/A
Human RTN4-2120HCL Recombinant Human RTN4 293 Cell Lysate HEK293 N/A
Human RTN4-3321H Recombinant Human RTN4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RTN4-3382H Recombinant Human RTN4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RTN4-756H Recombinant Human RTN4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RTN4-310H Recombinant Human RTN4 protein, GST-tagged E. coli GST 1-199 aa
Human RTN4-2036H Recombinant Human RTN4 Protein, His&GST-tagged E.coli N-His&GST Val1005-Asp1175
Mouse Rtn4-5643M Recombinant Mouse Rtn4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Rtn4-924R Active Recombinant Rat Rtn4 protein, IgG1-tagged Mammalian cells Fc
Rat Rtn4-1924R Active Recombinant Rat Reticulon 4, Fc Chimera Mammalian cells Fc
Rat RTN4-5195R Recombinant Rat RTN4 Protein Mammalian Cell His
Rat Rtn4-18R Recombinant Rat Rtn4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Rtn4-18R-B Recombinant Rat Rtn4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RTN4-4051R Recombinant Rhesus monkey RTN4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RTN4-3868R-B Recombinant Rhesus Macaque RTN4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RTN4-3868R Recombinant Rhesus Macaque RTN4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken RTN4-4718C Recombinant Chicken RTN4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Rtn4 Related Articles
  • Rtn4 Related Research Area

Rtn4 involved in several pathways and played different roles in them. We selected most pathways Rtn4 participated on our site, such as Axonal growth inhibition (RHOA activation), Signal Transduction, Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rtn4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axonal growth inhibition (RHOA activation)RTN4;LINGO1B;OMG;LINGO1;RTN4A;ARHGEF1B
Signal TransductionSKI;METAP2B;FFAR3;PTPRU;LRP12;AKAP13;MDKA;DACT1;INSL3
Signalling by NGFDNAL4;PRDM4;OMG;LINGO1B;RIT1;PCSK6;LINGO1;DNAL4A;RTN4
Spinal Cord InjuryPTPRZ1;NOX4;AIF1;OMG;LGALS3;KLK8;RGMA;TNFSF13B;MBP
p75 NTR receptor-mediated signallingAATF;RTN4;PRDM4;ARHGEF1B;RTN4A;OMG;LINGO1B;LINGO1
p75(NTR)-mediated signalingBEX1;MAGEH1;RTN4R;ZNF274;NDN;PRDM4;OMG;RTN4
p75NTR regulates axonogenesisLINGO1B;LINGO1;RTN4A;ARHGEF1B;RTN4;OMG

Rtn4 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rtn4 itself. We selected most functions Rtn4 had, and list some proteins which have the same functions with Rtn4. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingTNS1;HIST1H4H;NDUFV3;HEATR6;DUT;ANXA11;FAM98A;DDX55;RPS26
protein bindingFAM111A;CASP1;MPP1;HDDC3;SLAMF6;NKRF;SLC26A3;MAZ;HESX1

Rtn4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rtn4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rtn4.

SNX15; NCK2; SNX1; ARL6IP1; SYT16; ZFYVE21; RTN3

Herskowitz, JH; Seyfried, NT; et al. Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. JOURNAL OF PROTEOME RESEARCH 9:6368-6379(2010).
Klinger, M; Diekmann, H; et al. Identification of two nogo/rtn4 genes and analysis of Nogo-A expression in Xenopus laevis. MOLECULAR AND CELLULAR NEUROSCIENCE 25:205-216(2004).
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