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RuvC

  • Official Full Name

    RuvC

  • Overview

    In Escherichia coli, the RuvA, RuvB and RuvC proteins are required for the late stages of homologous recombination and DNA repair. They are involved in processing the Holliday junction during homologous recombination. RuvA protein binds to both single-stranded and double stranded DNA and enhances ATPase activity of RuvB. RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endonucleolytic cleavage. Moreover RuvAB stimulate Holliday junction resolution by RuvC. The RuvA-RuvB complex interacts with an irregular conformation in damaged DNA and induces conformational changes in DNA using energy provided by ATP hydrolysis, so that it facilitates DNA repair, recombination and error prone replication. RuvABC proteins are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be prevented.
  • Synonyms

    Crossover junction endodeoxyribonuclease ruvC; Holliday junction nuclease ruvC; Holliday junction resolvase ruvC; RuvC;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Akkermansia Muciniphila RUVC-2517A Recombinant Akkermansia Muciniphila RUVC Protein (1-167 aa), His-Myc-tagged E.coli His/Myc 1-167 aa
E.coli ruvC-133E Recombinant E. coli RuvC E.coli N/A
E.coli RuvC-2666E Recombinant E. coli Holliday Junction DNA Helicase RuvC E.coli N/A
Escherichia coli ruvC-4233E Recombinant Escherichia coli ruvC protein, His-SUMO-tagged E.coli His-SUMO 2-173aa
Streptomyces coelicolor A3(2) RUVC-1336S Recombinant Streptomyces coelicolor A3(2) RUVC protein, His-tagged E. coli or Yeast His

RuvC involved in several pathways and played different roles in them. We selected most pathways RuvC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RuvC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

RuvC has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by RuvC itself. We selected most functions RuvC had, and list some proteins which have the same functions with RuvC. You can find most of the proteins on our site.

Function Related Protein

RuvC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RuvC here. Most of them are supplied by our site. Hope this information will be useful for your research of RuvC.

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