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Official Full Name serine (or cysteine) peptidase inhibitor, clade A, member 1A
Background Alpha 1-Antitrypsin is a 52 kDA serine protease inhibitor (serpin) in blood, which protects tissue from enzymes from inflammatory cells, especially elastase. In certain acute phase inflammatory reactions, A1AT is elevated in order to limit the damage caused by activated neutrophil granulocytes and their enzyme elastase. Disorders of A1AT include A1AT deficiency, a hereditary disorder that can lead to severe tissue breakdown during inflammation. This may result in pulmonary emphysema and liver cirrhosis, in severe cases. Genetic variants of A1AT do occur.
Synonyms Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3; AAT; alpha-1 protease inhibitor 1; alpha-1-antiproteinase; alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; serine (or cysteine) proteinase inhibitor, clade A, member 1a; serine protease inhibitor 1-1; serine protease inhibitor A1a; serpin A1a
    • Species :
    • Mouse
    • Source :
    • E.coli
    • Human Cell
    • NS0
    • Tag :
    • Fc
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse SERPINA1A-001MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
    Mouse SERPINA1A-002MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
    Mouse SERPINA1A-003MCL Recombinant Mouse SERPINA1A cell lysate Human Cell N/A
    Mouse Serpina1a-1816M Recombinant Mouse Serpina1a protein, His-tagged E.coli His
    Mouse Serpina1a-304M Recombinant Mouse Serpina1a, His-tagged NS0 His
    Mouse Serpina1a-471M Recombinant Mouse Serpina1a Human Cell N/A
    Mouse Serpina1a-472M Recombinant Mouse Serpina1a, Fc-tagged Human Cell Fc
    Mouse Serpina1a-473M Recombinant Mouse Serpina1a, His-tagged Human Cell His

    serpina1a involved in several pathways and played different roles in them. We selected most pathways serpina1a participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with serpina1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades SERPINF2; CFH; KLKB1; C4BPA; F5; THBD; CR2; C8G; PROC; C3AR1

    serpina1a has several biochemical functions, for example, endopeptidase inhibitor activity, glycoprotein binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by serpina1a itself. We selected most functions serpina1a had, and list some proteins which have the same functions with serpina1a. You can find most of the proteins on our site.

    Function Related Protein
    endopeptidase inhibitor activity Serpina1c; PROS1; MUG2; PZP; SPINK1; RENBP; C3A.3; C3; A1i3; CST7
    glycoprotein binding SELP; SERPINA1D; ERLEC1; SDCBP; RASA1; EDEM1; SHB; Serpina1c; SERPINA1E; CSNK1D
    identical protein binding TRIM55; DYRK1A; UBE4A; CASP6; CORO1B; CCDC155; RGMB; CLDN2; COMMD1; TARDBP
    peptidase inhibitor activity ITIH3; PTTG2; SPINK6; SERPINA1A; KAL1A; SPINK12; SERPINB10; SPINK11; A2ML1; WFDC13
    protease binding FAP; ADAMTS4; POLG; FN1; TIMP2A; TYSND1; CCBE1; TIMP1; MALT1; ADRM1
    protein binding COPS3; CDK5R1; TMEM25; HSCB; PKM; VAMP1; FATE1; ATP10A; MACROD1; HTATIP2
    serine-type endopeptidase inhibitor activity SERPINA1E; FURIN; A2M; SERPINB13; SPINK8; SERPINB1L2; COL28A1; SERPINF2; SERPINB6B; WFDC6

    serpina1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with serpina1a here. Most of them are supplied by our site. Hope this information will be useful for your research of serpina1a.

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