Serpina1a
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Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 1A
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Overview
Alpha 1-Antitrypsin is a 52 kDA serine protease inhibitor (serpin) in blood, which protects tissue from enzymes from inflammatory cells, especially elastase. In certain acute phase inflammatory reactions, A1AT is elevated in order to limit the damage caused by activated neutrophil granulocytes and their enzyme elastase. Disorders of A1AT include A1AT deficiency, a hereditary disorder that can lead to severe tissue breakdown during inflammation. This may result in pulmonary emphysema and liver cirrhosis, in severe cases. Genetic variants of A1AT do occur. -
Synonyms
Aat-2; Aat2; Dom1; PI1; Spi1-1; Spi1-3; AAT; alpha-1 protease inhibitor 1; alpha-1-antiproteinase; alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; serine (or cysteine) proteinase inhibitor, clade A, member 1a; serine protease inhibitor 1-1; serine protease inhibitor A1a; serpin A1a;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Mouse
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- Fc
- His
- Avi
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | Serpina1a-304M | Active Recombinant Mouse Serpina1a, His-tagged | Mammalian cells | His | Glu25-Lys413 | |
Mouse | Serpina1a-471M | Active Recombinant Mouse Serpina1a protein | HEK293 | Non | Met1-Lys413 | |
Mouse | Serpina1a-473M | Recombinant Mouse Serpina1a, His-tagged | Human Cell | His | Met1-Lys413 | |
Mouse | Serpina1a-472M | Active Recombinant Mouse Serpina1a protein(Met1-Lys413), hFc-tagged | HEK293 | Fc | Met1-Lys413 | |
Mouse | Serpina1a-1816M | Recombinant Mouse Serpina1a protein, His-tagged | E.coli | His | Glu25~Lys413 | |
Mouse | SERPINA1A-001MCL | Recombinant Mouse SERPINA1A cell lysate | Human Cell | Non | ||
Mouse | SERPINA1A-003MCL | Recombinant Mouse SERPINA1A cell lysate | Human Cell | Non | ||
Mouse | SERPINA1A-002MCL | Recombinant Mouse SERPINA1A cell lysate | Human Cell | Non | ||
Mouse | Serpina1a-8039M-B | Recombinant Mouse Serpina1a Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Serpina1a-8039M | Recombinant Mouse Serpina1a Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
Serpina1a involved in several pathways and played different roles in them. We selected most pathways Serpina1a participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpina1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | C9;Hc;CR1L;PROS1;CFH;CR1;SERPINA1;Serpina1c;SERPINA1E |
Serpina1a has several biochemical functions, for example, endopeptidase inhibitor activity, glycoprotein binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpina1a itself. We selected most functions Serpina1a had, and list some proteins which have the same functions with Serpina1a. You can find most of the proteins on our site.
Function | Related Protein |
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endopeptidase inhibitor activity | SERPINF2;STFA2;C3B.2;SERPINA1A;MUG2;SPINK1;C4A;RECK;USP14 |
glycoprotein binding | BMPR1A;TGFB1;PLAT;CNTN2;LGALS1;STX1A;TFR2;BMPR1B;RAB14 |
identical protein binding | SNX33;S100A1;PTEN;PFKM;TP73;L1CAM;MUL1;ALAD;HAND1 |
peptidase inhibitor activity | WFDC18;EPPIN;PI16;SERPINA1E;PTTG1;KAL1A;PTTG2;WFDC6A;SERPINB1C |
protease binding | SERPINB3;ANXA2;C10orf2;RYR1;INS1;FLOT2;ADAMTS4;SERPINA1;CNTNAP2 |
protein binding | BLOC1S2A;ZNF10;CHAMP1;KBTBD7;ARL4A;RRAGC;KLF15;BBS10;HNRNPH1 |
serine-type endopeptidase inhibitor activity | AMBP;SERPINE2;SERPINA5;WFDC13;SPINT1;SERPINB11;SPINK13;SERPINA1A;SERPINB1C |
Serpina1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpina1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpina1a.
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