SGCA

  • Official Full Name

    sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

  • Overview

    This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    SGCA; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); ADL, sarcoglycan, alpha (50kD dystrophin associated glycoprotein); alpha-sarcoglycan; 50kD DAG; A2; adhalin; adhalin (limb girdle muscular dystrophy 2D); DMDA2; LGMD2D; Sarcoglycan; alpha (50kD dystrophin associated glycoprotein; adhalin); SCARMD1; 50DAG; 59kDa; ADL; DAG2; 50 DAG; 50 kDa dystrophin associated glycoprotein; 50 kDa dystrophin-associated glycoprotein; Alpha SG; Alpha-SG; Asg; Dystroglycan 2; Dystroglycan-2; sarcoglycan, alpha (dystrophin-associated glycoprotein); SGCA_HUMAN; OTTHUMP00000221051; OTTHUMP00000221052; OTTHUMP00000221053; 50-DAG;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SGCA-27337TH Recombinant Human SGCA Wheat Germ N/A 108 amino acids
Human SGCA-1890HCL Recombinant Human SGCA 293 Cell Lysate HEK293 N/A
Human SGCA-1669H Recombinant Human SGCA protein, His & GST-tagged E.coli His/GST Gln24~His387 (Accession # Q16586)
Human SGCA-02H Recombinant Human SGCA Protein, Myc/DDK-tagged HEK293 Myc/DDK
Human SGCA-01H Recombinant Human SGCA Protein, Myc/DDK-tagged HEK293 Myc/DDK
Human SGCA-3498H Recombinant Human SGCA protein, His-tagged E.coli His 24-105 aa
Human SGCA-545HFL Recombinant Full Length Human SGCA Protein, C-Flag-tagged Mammalian cells Flag
Human SGCA-1994H-B Recombinant Human SGCA Protein Pre-coupled Magnetic Beads HEK293
Human SGCA-1994H Recombinant Human SGCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SGCA-15028M Recombinant Mouse SGCA Protein Mammalian Cell His
Mouse Sgca-3387M Recombinant Mouse Sgca, His-tagged E.Coli or Yeast His 387
Mouse SGCA-8095M-B Recombinant Mouse SGCA Protein Pre-coupled Magnetic Beads HEK293
Mouse Sgca-5820M Recombinant Mouse Sgca Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SGCA-8095M Recombinant Mouse SGCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mus musculus (Mouse) RFL18226MF Recombinant Full Length Mouse Alpha-Sarcoglycan(Sgca) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-387)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SGCA involved in several pathways and played different roles in them. We selected most pathways SGCA participated on our site, such as Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)CACNB3;ITGA10;TNNI3;CACNA2D3;CACNG4;SGCB;ITGA2B;TPM3;ITGB6
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGB8;SGCD;CACNG6;ITGA2;TCF7L2;DMD;CACNG2;CACNG1;ITGA10
Dilated cardiomyopathyACTC1;TGFB1;TPM4;CACNG3;MYL3;ACTB;ITGA2;ITGB5;CACNG8
Viral myocarditisHLA-DMA;ITGAL;FYN;HLA-DRA;CXADR;HLA-DQB1;HLA-DRB4;ABL2;HLA-DPB1

SGCA has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGCA itself. We selected most functions SGCA had, and list some proteins which have the same functions with SGCA. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCABP1B;EFCAB9;MYL9;PLSCR4;NCAN;CCBE1;F9B;COL4A3BPA;DAG1
protein bindingCD46;CENPO;ASNA1;XAGE2;PKN1;PARN;RLN3;NME1;ACLY

SGCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCA.

SGTA; FN1; TAF1; FSTL1; ITGB1BP2

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