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Official Full Name SH2B adaptor protein 3
Background This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
Synonyms SH2B3; SH2B adaptor protein 3; SH2B adapter protein 3; IDDM20; LNK; lymphocyte adaptor protein; signal transduction protein Lnk; lymphocyte-specific adapter protein Lnk
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • DDK/His
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SH2B3-051H Recombinant Human SH2B3 Mutant (R262W) Protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human SH2B3-054H Recombinant Human SH2B3 Mutant (R262W) Protein, DDK/His-tagged HEK293 DDK/His
    Human SH2B3-1880HCL Recombinant Human SH2B3 293 Cell Lysate HEK293 N/A
    Human SH2B3-2638H Recombinant Human SH2B3, His-tagged E.coli His
    Human SH2B3-3773H Recombinant Human SH2B3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Sh2b3-1332M Recombinant Mouse Sh2b3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse SH2B3-15053M Recombinant Mouse SH2B3 Protein Mammalian Cell His
    Mouse Sh2b3-1557M Recombinant Mouse Sh2b3 protein, His & T7-tagged E.coli His/T7
    Rat SH2B3-5373R Recombinant Rat SH2B3 Protein Mammalian Cell His

    sh2b3 involved in several pathways and played different roles in them. We selected most pathways sh2b3 participated on our site, such as EPO signaling pathway, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with sh2b3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EPO signaling pathway SH2B3
    Factors involved in megakaryocyte development and platelet production IRF2A; GATA2A; ITPK1; HBBE2; MFN1; IRF1B; KIF9; KDM1A; KIF3B; HBBE1.1
    Hemostasis KIF4A; F9B; ANXA2A; SLC7A6; PDE10A; GATA6; CABLES2; MAFF; STXBP3A; SH2B3
    Neurotrophin signaling pathway BCL2; PRKCD; RAP1A; SHC3; CAMK2B; NFKB1; RELA; SH2B3; ATF4; PLCG1
    Regulation of KIT signaling SH2B3
    Signal Transduction ARHGEF1A; AKR1C21; UTS2D; PTHLHA; GPR177; ALDH8A1; PNOCB; GPR31; USP9; SH2B3
    Signaling by SCF-KIT GRAP; PTPRUB; SH2B3; PTPRU
    Signaling events mediated by Stem cell factor receptor (c-Kit) STAP1; EVLA; MAP4K1; PTPRO; SH2B3

    sh2b3 has several biochemical functions, for example, phosphate ion binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sh2b3 itself. We selected most functions sh2b3 had, and list some proteins which have the same functions with sh2b3. You can find most of the proteins on our site.

    Function Related Protein
    phosphate ion binding ADSS; PNP; SLC34A2; ADSSL1; G6PC; MTHFD2; RPH3A; GNG12; CHST14; OTC
    protein binding TRAPPC10; UBE2E3; TAF9; Cd79a, Cd79b; LYN; TRPC2; POLR1B; HELZ; SOX-2; ISG20L2
    protein complex binding PTK2B; LRP2; GIT2; DRD1A; TRADD; Apba1; PEX1; HSPD1; IST1; KAT2B
    signal transducer activity CC2D1A; OLFR474; OLFR50; PROKR1A; OLFR11; TICAM1; TAS2R103; TRIM55; MAPKAPK2A; ADORA2AA
    signaling adaptor activity SH2B2; AFAP1L2; HOMER1; SH2B1; LDLRAP1; SH2B3; MPP7; GNB2L1

    sh2b3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sh2b3 here. Most of them are supplied by our site. Hope this information will be useful for your research of sh2b3.


    Bonifacio, E; Krumsiek, J; et al. A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. ACTA DIABETOLOGICA 51:403-411(2014).
    Ochoa, E; Iriondo, M; et al. Thrombotic Antiphospholipid Syndrome Shows Strong Haplotypic Association with SH2B3-ATXN2 Locus. PLOS ONE 8:-(2013).

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