Recombinant Mouse Sh2b3 protein, His & T7-tagged Sh2b3-1557M

Recombinant Mouse Sh2b3 protein, His & T7-tagged


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Recombinant Mouse Sh2b3 protein, His & T7-tagged

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Cat.No. : Sh2b3-1557M
Product Overview : Recombinant Mouse Sh2b3 aa. (Ala225~Val447 (Accession # O09039)) fused with N-terminal His & T7 tag was produced in E. coli cells.
Description : This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : E. coli
Species : Mouse
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 28.3kDa
Protein length : Ala225~Val447 (Accession # O09039)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 6.3

Gene Name : Sh2b3 SH2B adaptor protein 3 [ Mus musculus (house mouse) ]
Official Symbol : Sh2b3
Synonyms : Sh2b3; SH2B adaptor protein 3; Lnk; AI429800; linker of T-cell receptor pathways; lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk
Gene ID : 16923
mRNA Refseq : NM_001306126.1
Protein Refseq : NP_001293055.1
UniProt ID : O09039

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