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SH2D1B

  • Official Full Name

    SH2 domain containing 1B

  • Overview

    By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal;transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 (PubMed;11689425)).
  • Synonyms

    SH2D1B; SH2 domain containing 1B; SH2 domain-containing protein 1B; EAT2; EAT 2; EWS/FLI1 activated transcript 2; SH2 domain containing molecule EAT2; SH2 domain containing protein 1B; EAT-2; EWS/FLI1-activated transcript 2; SH2 domain-containing molecule EAT2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SH2D1B-2640H Recombinant Human SH2D1B, GST-tagged E.coli GST 1-132aa
Human SH2D1B-1597HCL Recombinant Human SH2D1B cell lysate N/A
Human SH2D1B-2001H-B Recombinant Human SH2D1B Protein Pre-coupled Magnetic Beads HEK293
Human SH2D1B-1337H Recombinant Human SH2D1B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SH2D1B-210H Recombinant Human SH2D1B Protein, His-tagged Insect Cell His 1-132aa
Human SH2D1B-2001H Recombinant Human SH2D1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SH2D1B-2183HFL Recombinant Full Length Human SH2D1B Protein, C-Flag-tagged Mammalian cells Flag
Chicken SH2D1B-5343C Recombinant Chicken SH2D1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SH2D1B Related Articles

SH2D1B involved in several pathways and played different roles in them. We selected most pathways SH2D1B participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemGAN;CD160;BLK;CDKN1B;AP1B1;NPEPPS;MOV10;KLHL21;CLTA
Immune SystemSIGLEC14;PPAPDC1A;ART1;PAG1;GRAP2B;FCN1;MASP2;TAX1BP1B;NOD1
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellCD300LB;HCST;CD226;KLRF1;SIGLEC11;SIGLEC8;LAIR2;KIR2DS2;CD200
Natural killer cell mediated cytotoxicityRAET1L;IFNA1;SHC2;KIR2DL3;FAS;HCST;HLA-E;IFNA6;VAV3

SH2D1B has several biochemical functions, for example, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D1B itself. We selected most functions SH2D1B had, and list some proteins which have the same functions with SH2D1B. You can find most of the proteins on our site.

Function Related Protein
protein bindingKIAA0146;TEX10;UVRAG;APC2;MCM10;BSG;CD59;TRIP12;TSR2
protein binding, bridgingSPRR1B;FSCN3;SH2D1B;FSCN2B;GOLGA5;ANK2;FLRT2;RBM14;TRIM17

SH2D1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D1B.

q53hf2_human; TRIM54; CD84; OLIG1; STAT4; ERBB2; MET

Kurzer, JH; Argetsinger, LS; et al. Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. MOLECULAR AND CELLULAR BIOLOGY 24:4557-4570(2004).
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