SIAH1

  • Official Full Name

    seven in absentia homolog 1 (Drosophila)

  • Overview

    This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

  • Synonyms

    SIAH1;seven in absentia homolog 1 (Drosophila);E3 ubiquitin-protein ligase SIAH1;hSIAH1;HUMSIAH;Seven in absentia homolog 1;SIAH 1;Siah 1a;Ubiquitin ligase SIAH1;siah-1a;OTTHUMP00000164188;OTTHUMP00000164189;SIAH1A

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SIAH1-2668H Recombinant Human SIAH1 protein, GST-tagged E.coli Human GST
SIAH1-4200R Recombinant Rhesus monkey SIAH1 Protein, His-tagged Mammalian Cells Rhesus macaque His
SIAH1-9929Z Recombinant Zebrafish SIAH1 Mammalian Cells Zebrafish His
SIAH1-1851HCL Recombinant Human SIAH1 293 Cell Lysate HEK293 Human Non
SIAH1-4016R Recombinant Rhesus Macaque SIAH1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SIAH1-4016R-B Recombinant Rhesus Macaque SIAH1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SIAH1-4353H Recombinant Human SIAH1 protein, GST-tagged E.coli Human GST
SIAH1-4629H Recombinant Human SIAH1 protein, GST-tagged E.coli Human GST 1-313aa

    Involved Pathway

    SIAH1 involved in several pathways and played different roles in them. We selected most pathways SIAH1 participated on our site, such as p signaling pathway,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis SKP1,NEDD4L,ITCH,CDC27,SOCS1A,FBXW7,UBE2G2,UBE2IB,CUL1,KLHL13
    p signaling pathway CCND1,CD82B,CASP3A,CD82A,IGF1,CCNG2,CASP9,ZMAT3,GADD45B,APAF1
    Wnt signaling pathway PORCNL,LEF1,VANGL2,RHOAC,NKD2B,WNT11B,NFATC3,SFRP1,CACYBP,NKD1

    Protein Function

    SIAH1 has several biochemical functions, for example, identical protein binding,ligase activity,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH1 itself. We selected most functions SIAH1 had, and list some proteins which have the same functions with SIAH1. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding CLDN6,GCG,SH3BP4,SCUBE1,SDF4,TRIP10,ATF3,SID4,SNX1,SMN2
    zinc ion binding SEC24D,KDM5C,GFI1AB,LIMD2,RNF43,GDA,KDM5BA,NR3C2,MMP30,MATR3L
    protein C-terminus binding FIGN,ATP1B1,DLG3,PPP2CA,ITGB3BP,DDX1,MPDZ,SDC1,ATF4,CLIC6
    ligase activity NEDD4L,RNF114,RNF168,TRIM58,ZNRF2,RBX1,MARCH5L,DTX1,UBE2L3B,UHRF2
    ubiquitin-protein transferase activity TRAF7,UBE2A,RNF4,FBXO21,FBXO3,FBXO30B,TRAF3,MARCH2,TRIM69,UBE2M
    protein binding RBM6,FAM193B,RNF180,AP1G1,ZC3H8,MITF,KHDRBS2,SHISA3,CCNA2,CCK
    ubiquitin protein ligase activity UBE2J2,FBXW11,RNF180,CDC34A,UHRF1,TRIM59,UBE2Z,PJA2,MED24,UBE2G1

    Interacting Protein

    SIAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH1.

    PHC2;PUF60;EEF1D;UBE2K

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