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SIGMAR1

  • Official Full Name

    sigma non-opioid intracellular receptor 1

  • Overview

    This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
  • Synonyms

    SIGMAR1; sigma non-opioid intracellular receptor 1; opioid receptor, sigma 1 , OPRS1; SR BP1; SR-BP; SIG-1R; sigma1R; hSigmaR1; SR31747 binding protein 1; sigma 1-type opioid receptor; aging-associated gene 8 protein; SRBP; ALS16; OPRS1; SR-BP1; MGC3851;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SIGMAR1-12H Recombinant Human SIGMAR1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SIGMAR1-13H Recombinant Human SIGMAR1 protein, GST-tagged Wheat Germ GST
Human SIGMAR1-1843HCL Recombinant Human SIGMAR1 293 Cell Lysate HEK293 N/A
Human SIGMAR1-5128H Recombinant Human SIGMAR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SIGMAR1-2473HFL Recombinant Full Length Human SIGMAR1 protein, Flag-tagged Mamanlian cells Flag
Human SIGMAR1-629HF Recombinant Full Length Human SIGMAR1 Protein, GST-tagged In Vitro Cell Free System GST 223 amino acids
Mouse SIGMAR1-15133M Recombinant Mouse SIGMAR1 Protein Mammalian Cell His
Mouse Sigmar1-5877M Recombinant Mouse Sigmar1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SIGMAR1-8171M Recombinant Mouse SIGMAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SIGMAR1-8171M-B Recombinant Mouse SIGMAR1 Protein Pre-coupled Magnetic Beads HEK293
Rat SIGMAR1-5401R Recombinant Rat SIGMAR1 Protein Mammalian Cell His
Rat SIGMAR1-5060R-B Recombinant Rat SIGMAR1 Protein Pre-coupled Magnetic Beads HEK293
Rat SIGMAR1-5060R Recombinant Rat SIGMAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SIGMAR1-4203R Recombinant Rhesus monkey SIGMAR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SIGMAR1-4019R Recombinant Rhesus Macaque SIGMAR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SIGMAR1-4019R-B Recombinant Rhesus Macaque SIGMAR1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SIGMAR1-11212Z Recombinant Zebrafish SIGMAR1 Mammalian Cell His
Chicken SIGMAR1-4646C Recombinant Chicken SIGMAR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SIGMAR1 Related Articles

SIGMAR1 involved in several pathways and played different roles in them. We selected most pathways SIGMAR1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGMAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SIGMAR1 has several biochemical functions, for example, drug binding, opioid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGMAR1 itself. We selected most functions SIGMAR1 had, and list some proteins which have the same functions with SIGMAR1. You can find most of the proteins on our site.

Function Related Protein
drug bindingPIGC;PYGB;DRD2;GPR30;FABP1;GRIK1;CHRM2;P2RX1;PDXK
opioid receptor activityOPRD1B;NPBWR2;NPBWR1;OPRD1A;OPRK1;OPRD1;OGFR;SIGMAR1

SIGMAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGMAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGMAR1.

CLN3; PDZD11; pi3p

Moon, JY; Roh, DH; et al. sigma 1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain. BRITISH JOURNAL OF PHARMACOLOGY 171:5881-5897(2014).
Lovkvist, H; Jonsson, AC; et al. Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke. BMC NEUROLOGY 14:-(2014).
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