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Official Full Name SIX homeobox 1
Background The protein encoded by this gene is a homeobox protein that is similar to the Drosophila sine oculis gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
Synonyms SIX1; SIX homeobox 1; deafness, autosomal dominant 23 , DFNA23, sine oculis homeobox (Drosophila) homolog 1 , sine oculis homeobox homolog 1 (Drosophila); homeobox protein SIX1; BOS3; DFNA23; OTTHUMP00000179042; Sine oculis homeobox homolog 1; SIX1_HUMAN; TIP39
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIX1-1825HCL Recombinant Human SIX1 293 Cell Lysate HEK293 N/A
    Human SIX1-30869TH Recombinant Human SIX1 Wheat Germ N/A
    Human SIX1-7160H Recombinant Human SIX Homeobox 1, His-tagged E.coli His
    Chicken SIX1-3477C Recombinant Chicken SIX1 Mammalian Cell His

    six1 involved in several pathways and played different roles in them. We selected most pathways six1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with six1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer WHSC1; MLF1; MET; TP53; PLAU; HMGA2; CEBPE; ERG; CD40; RXRA

    six1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by six1 itself. We selected most functions six1 had, and list some proteins which have the same functions with six1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TERFA; SPTY2D1; ZNF445; TIGD6; C5orf20; SMARCB1; PAX3A; SIM2; ZNF501; SRRT
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ATF3; NFATC4; GATA1; ZNF664; MYF6; GABPA; EBF2; POU4F3; PAX5; GMEB2
    chromatin binding BAZ1B; CDC45; EED; SP140L; ATOH1A; ZFP932; MSGN1; EYA3; JDP2; JUB
    protein binding C10orf33; FRS2; ANKRD49; MATK; REEP5; ZMAT4; ZKSCAN3; PSMB4; SNX6; EVI5L
    sequence-specific DNA binding ZNF192; HOXB10A; FOXG1C; NR1D2B; HOXA10B; FOXF2; HMX2; FOXI3B; IRX5A; POU3F3B
    transcription factor activity, sequence-specific DNA binding E2F5; ALX1; CREB3L3A; CNOT8; NKX2; NR3C1; ZFP82; RUNX1; HOXB3A; HOXD10
    transcription regulatory region DNA binding HDAC1; TFAP4; HIVEP3; SMAD3; GABPB1; STAT3; ARRB1; TP53; JUND; TRP63
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding STAT3; CEBPB; CAMTA2; ONECUTL; EBF3A; ATOH1; MEIS3; PLAG1; MAFB; TTC6

    six1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with six1 here. Most of them are supplied by our site. Hope this information will be useful for your research of six1.


    Tan, WJ; Thike, AA; et al. Immunohistochemical expression of homeoproteins Six1 and Pax3 in breast phyllodes tumours correlates with histological grade and clinical outcome. HISTOPATHOLOGY 64:807-817(2014).
    Qamar, L; Deitsch, E; et al. Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. GYNECOLOGIC ONCOLOGY 125:451-457(2012).

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